SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A  54
VAL A  57
ILE A 249
GLY A 293
ILE A 341
 None
 0.91A 1c6zB-1yy3A:
undetectable		 1c6zB-1yy3A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 10 VAL A 242
ARG A 243
VAL A  57
ILE A 291
LEU A 239
 None
 1.21A 1fe2A-1yy3A:
undetectable		 1fe2A-1yy3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 8 VAL A 242
ARG A 243
VAL A  57
ILE A 291
LEU A 239
 None
 1.20A 1igxA-1yy3A:
undetectable		 1igxA-1yy3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 11 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.85A 1z11A-1yy3A:
undetectable		 1z11A-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 11 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.83A 1z11B-1yy3A:
undetectable		 1z11B-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 10 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.86A 1z11C-1yy3A:
undetectable		 1z11C-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 10 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.91A 1z11D-1yy3A:
undetectable		 1z11D-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		4 / 7 LEU A  56
PHE A  50
ILE A 295
PHE A  43
 None
 0.96A 2opxA-1yy3A:
undetectable		 2opxA-1yy3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A  54
VAL A  57
ILE A 249
GLY A 293
ILE A 341
 None
 0.91A 2q5kB-1yy3A:
undetectable		 2q5kB-1yy3A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ILE A 154
PHE A 110
PHE A 132
LEU A 115
ALA A  66
 None
 1.45A 3apwB-1yy3A:
undetectable		 3apwB-1yy3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 GLN A 133
LEU A  81
THR A  94
LEU A 115
ARG A 114
 None
 1.36A 3fsuA-1yy3A:
undetectable		 3fsuA-1yy3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 11 GLN A 133
LEU A  81
THR A  94
LEU A 115
ARG A 114
 None
 1.44A 3fsuE-1yy3A:
0.6		 3fsuE-1yy3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 10 ILE A  46
PHE A  43
ILE A 188
SER A 251
HIS A 183
 None
 1.27A 3o1cA-1yy3A:
undetectable		 3o1cA-1yy3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		3 / 3 PHE A 201
VAL A 242
ILE A 249
 None
 0.52A 4emaA-1yy3A:
undetectable		 4emaA-1yy3A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 TYR A 286
GLU A 227
LEU A 260
ILE A 291
LEU A 312
 None
 1.29A 4k38A-1yy3A:
undetectable
4k38D-1yy3A:
undetectable		 4k38A-1yy3A:
21.53
4k38D-1yy3A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A  54
VAL A  57
ILE A 249
GLY A 293
ILE A 341
 None
 0.99A 4njuA-1yy3A:
undetectable		 4njuA-1yy3A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A  54
VAL A  57
ILE A 249
GLY A 293
ILE A 341
 None
 1.00A 4njuC-1yy3A:
undetectable		 4njuC-1yy3A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 11 THR A 257
SER A 256
GLY A 253
GLU A 227
THR A  61
 None
 1.40A 4xt7A-1yy3A:
undetectable		 4xt7A-1yy3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		4 / 6 TYR A 229
LEU A 208
GLU A  93
LEU A  84
 None
 1.39A 5xooA-1yy3A:
undetectable		 5xooA-1yy3A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A  54
VAL A  57
ILE A 249
GLY A 293
ILE A 341
 None
 1.00A 6dilA-1yy3A:
undetectable		 6dilA-1yy3A:
16.07