SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 4 ARG A  20
ALA A  19
ALA A  49
GLU A  51
 PO4  A2001 (-4.2A)
None
None
None
 1.13A 1e7bA-1yyaA:
undetectable		 1e7bA-1yyaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 LEU A 243
SER A 241
PHE A 242
ALA A 235
 None
 0.71A 1j8uA-1yyaA:
undetectable		 1j8uA-1yyaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 5 GLU A 240
LEU A 246
LEU A 243
LEU A 245
 None
 0.92A 1np1A-1yyaA:
undetectable		 1np1A-1yyaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 150
ALA A  62
PHE A  43
ALA A  90
LEU A 116
 None
 1.17A 1rbpA-1yyaA:
undetectable		 1rbpA-1yyaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 VAL A 153
THR A 121
PRO A 122
LEU A 124
 None
 0.93A 1z2bB-1yyaA:
undetectable		 1z2bB-1yyaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 7 THR A 121
PRO A 122
VAL A 162
GLU A 159
ARG A 206
 None
 1.27A 2v41E-1yyaA:
undetectable
2v41F-1yyaA:
undetectable		 2v41E-1yyaA:
22.61
2v41F-1yyaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 LEU A  40
PRO A  41
ALA A  49
LEU A  46
 None
 0.82A 2vcvF-1yyaA:
undetectable		 2vcvF-1yyaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
PO4  A2004 (-3.2A)
None
None
None
 1.10A 2x1lA-1yyaA:
undetectable		 2x1lA-1yyaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
PO4  A2004 (-3.2A)
None
None
None
 1.12A 2x1lC-1yyaA:
undetectable		 2x1lC-1yyaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
ALA A   7
VAL A   4
GLY A 229
ILE A 123
 None
 0.88A 3ekqA-1yyaA:
undetectable		 3ekqA-1yyaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		6 / 12 GLY A   8
ALA A   7
VAL A 162
GLY A 210
VAL A  92
ILE A 123
 None
 1.37A 3jw2B-1yyaA:
undetectable		 3jw2B-1yyaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		6 / 12 GLY A   8
ALA A   7
VAL A 162
GLY A 210
VAL A  92
ILE A 123
 None
 1.30A 3k4vB-1yyaA:
undetectable		 3k4vB-1yyaA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 VAL A  39
VAL A 232
GLY A   8
PHE A  23
LEU A  26
 None
 1.18A 3mecA-1yyaA:
undetectable		 3mecA-1yyaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 230
ILE A 163
VAL A 162
 None
 0.52A 3nv6A-1yyaA:
undetectable		 3nv6A-1yyaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 HIS A  94
GLY A 211
ILE A 171
 None
PO4  A2004 ( 3.9A)
PO4  A2004 (-4.4A)
 0.64A 4k50A-1yyaA:
undetectable		 4k50A-1yyaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 HIS A  94
GLY A 211
ILE A 171
 None
PO4  A2004 ( 3.9A)
PO4  A2004 (-4.4A)
 0.64A 4k50I-1yyaA:
undetectable		 4k50I-1yyaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 231
LEU A 208
GLY A 230
LEU A 245
VAL A  39
 None
 1.24A 4olmA-1yyaA:
undetectable		 4olmA-1yyaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 157
PRO A 158
ALA A 202
 None
 0.48A 4qn9B-1yyaA:
undetectable		 4qn9B-1yyaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 LEU A 246
VAL A  39
VAL A 232
GLY A   8
LEU A  26
 None
 1.39A 5hbmA-1yyaA:
1.4		 5hbmA-1yyaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PO4  A2004 (-4.0A)
None
None
None
 1.40A 5jh7B-1yyaA:
undetectable		 5jh7B-1yyaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PO4  A2004 (-4.0A)
None
None
None
 1.40A 5jh7D-1yyaA:
undetectable		 5jh7D-1yyaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 208
GLY A 233
ASN A   9
LEU A  40
ALA A  38
 None
PO4  A2004 (-3.2A)
None
None
None
 1.36A 5kbwA-1yyaA:
undetectable		 5kbwA-1yyaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLU A 166
LEU A 208
GLY A 233
ASN A   9
ALA A  38
 None
None
PO4  A2004 (-3.2A)
None
None
 1.32A 5kc4A-1yyaA:
undetectable		 5kc4A-1yyaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1yya TRIOSEPHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 TRP A  10
GLU A 238
GLU A  18
 None
None
PO4  A2007 ( 4.5A)
 0.97A 6fhwA-1yyaA:
undetectable		 6fhwA-1yyaA:
16.80