SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4S_A_TPVA201_1 (PROTEIN (HIV-1 PROTEASE))	1yyh	NOTCH 1, ANKYRIN DOMAIN (Homo sapiens)	5 / 10	LEU A 63 ALA A 72 ASP A 71 ILE A 108 PRO A 93	None	1.19A	1d4sA-1yyhA: undetectable	1d4sA-1yyhA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WUZ_A_TPFA1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE , PUTATIVE)	1yyh	NOTCH 1, ANKYRIN DOMAIN (Homo sapiens)	5 / 10	ALA A 160 ALA A 164 THR A 205 LEU A 209 VAL A 208	None	1.35A	2wuzA-1yyhA: undetectable	2wuzA-1yyhA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_B_SAMB6735_0 (16S RRNA METHYLASE)	1yyh	NOTCH 1, ANKYRIN DOMAIN (Homo sapiens)	5 / 12	GLY A 138 VAL A 136 ALA A 160 THR A 126 LEU A 128	None	1.17A	3p2kB-1yyhA: undetectable	3p2kB-1yyhA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_2 (TUBULIN BETA CHAIN)	1yyh	NOTCH 1, ANKYRIN DOMAIN (Homo sapiens)	5 / 12	LEU A 128 ALA A 148 ASN A 145 VAL A 98 ALA A 131	None	1.12A	4x1iB-1yyhA: undetectable	4x1iB-1yyhA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_D_GLYD713_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	1yyh	NOTCH 1, ANKYRIN DOMAIN (Homo sapiens)	3 / 3	ARG A 66 HIS A 62 ARG A 91	None	1.18A	6dwdD-1yyhA: undetectable	6dwdD-1yyhA: 18.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4S_A_TPVA201_1","PROTEIN (HIV-1 PROTEASE)","1yyh","NOTCH 1, ANKYRIN DOMAIN","Homo sapiens",5,"LEU A  63;ALA A  72;ASP A  71;ILE A 108;PRO A  93","None","1.19A","1d4sA-1yyhA:undetectable","1d4sA-1yyhA:14.29"],["2WUZ_A_TPFA1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE","1yyh","NOTCH 1, ANKYRIN DOMAIN","Homo sapiens",5,"ALA A 160;ALA A 164;THR A 205;LEU A 209;VAL A 208","None","1.35A","2wuzA-1yyhA:undetectable","2wuzA-1yyhA:21.09"],["3P2K_B_SAMB6735_0","16S RRNA METHYLASE","1yyh","NOTCH 1, ANKYRIN DOMAIN","Homo sapiens",5,"GLY A 138;VAL A 136;ALA A 160;THR A 126;LEU A 128","None","1.17A","3p2kB-1yyhA:undetectable","3p2kB-1yyhA:21.32"],["4X1I_B_LOCB502_2","TUBULIN BETA CHAIN","1yyh","NOTCH 1, ANKYRIN DOMAIN","Homo sapiens",5,"LEU A 128;ALA A 148;ASN A 145;VAL A  98;ALA A 131","None","1.12A","4x1iB-1yyhA:undetectable","4x1iB-1yyhA:19.82"],["6DWD_D_GLYD713_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","1yyh","NOTCH 1, ANKYRIN DOMAIN","Homo sapiens",3,"ARG A  66;HIS A  62;ARG A  91","None","1.18A","6dwdD-1yyhA:undetectable","6dwdD-1yyhA:18.71"]]