SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 7 SER A  88
VAL A  61
THR A  97
ILE A  63
 SO4  A 211 (-2.5A)
None
None
None
 0.86A 1gtnC-1yz4A:
undetectable
1gtnD-1yz4A:
undetectable		 1gtnC-1yz4A:
18.01
1gtnD-1yz4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		3 / 3 ARG A 132
VAL A  99
GLY A  15
 None
 0.54A 2avvE-1yz4A:
undetectable		 2avvE-1yz4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		3 / 3 SER A 143
GLY A 108
GLY A 110
 None
 0.57A 3bogA-1yz4A:
undetectable
3bogC-1yz4A:
undetectable		 3bogA-1yz4A:
undetectable
3bogC-1yz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 4 ASN A  83
SER A  95
LEU A  14
THR A  32
 None
SO4  A 211 ( 4.5A)
None
None
 1.39A 4an2A-1yz4A:
undetectable		 4an2A-1yz4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 5 TYR A 102
ILE A  98
ASN A  72
ILE A  35
 None
 0.92A 4jtpA-1yz4A:
undetectable		 4jtpA-1yz4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		3 / 3 LEU A   9
PRO A  10
ARG A 147
 None
 0.59A 4klrB-1yz4A:
2.0		 4klrB-1yz4A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 4 ASN A 128
VAL A  55
THR A  97
ILE A  98
 None
 1.26A 4retA-1yz4A:
3.5		 4retA-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 4 ASN A 128
VAL A  61
THR A  97
ILE A  98
 None
 1.37A 4retA-1yz4A:
3.5		 4retA-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 4 ASN A 128
VAL A  55
THR A  97
ILE A  98
 None
 1.26A 4retC-1yz4A:
3.4		 4retC-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 4 ASN A 128
VAL A  61
THR A  97
ILE A  98
 None
 1.37A 4retC-1yz4A:
3.4		 4retC-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		3 / 3 ASP A  57
LEU A  14
ARG A 122
 SO4  A 211 ( 4.2A)
None
None
 0.84A 5e8qA-1yz4A:
undetectable		 5e8qA-1yz4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 7 THR A 105
ILE A 118
VAL A 114
PRO A 127
 None
 0.94A 6cduF-1yz4A:
undetectable
6cduJ-1yz4A:
undetectable		 6cduF-1yz4A:
19.12
6cduJ-1yz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens) 		4 / 7 ILE A 118
VAL A 114
PRO A 127
THR A 105
 None
 0.96A 6cduF-1yz4A:
undetectable
6cduG-1yz4A:
undetectable		 6cduF-1yz4A:
19.12
6cduG-1yz4A:
19.12