SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 199
ILE A 194
ALA A 258
VAL A 186
LEU A 261
 None
 0.94A 1cbsA-1yz6A:
undetectable		 1cbsA-1yz6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ALA A 198
ILE A 251
PHE A 216
LEU A 260
ILE A 243
 None
 1.06A 1dg5A-1yz6A:
undetectable		 1dg5A-1yz6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 GLU A 112
LEU A 106
LEU A 109
LEU A 107
 None
 1.00A 1np1A-1yz6A:
undetectable		 1np1A-1yz6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		6 / 12 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
GLY A  26
 None
 1.13A 1qknA-1yz6A:
undetectable		 1qknA-1yz6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 199
ILE A 194
ALA A 258
VAL A 186
LEU A 261
 None
 0.89A 2fr3A-1yz6A:
undetectable		 2fr3A-1yz6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
 None
 0.98A 2jfaA-1yz6A:
undetectable		 2jfaA-1yz6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 ILE A 251
ARG A 201
ILE A 243
PHE A 182
 None
 1.00A 2q6hA-1yz6A:
undetectable		 2q6hA-1yz6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 ILE A 251
ARG A 201
ILE A 243
PHE A 182
 None
 1.00A 2q72A-1yz6A:
undetectable		 2q72A-1yz6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 ILE A 251
ARG A 201
ILE A 243
PHE A 182
 None
 1.00A 2qb4A-1yz6A:
undetectable		 2qb4A-1yz6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
 None
 0.93A 2qxsA-1yz6A:
undetectable		 2qxsA-1yz6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
 None
 0.94A 2qxsB-1yz6A:
undetectable		 2qxsB-1yz6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 GLY A 147
ILE A 148
ILE A 167
ASP A 146
 None
 0.93A 3a7eA-1yz6A:
undetectable		 3a7eA-1yz6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ALA A 180
LEU A 260
ALA A 258
ILE A 247
PHE A 216
 None
 0.96A 3fl9F-1yz6A:
undetectable		 3fl9F-1yz6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A  17
LEU A  80
LEU A  82
ILE A  54
GLY A  26
 None
 1.11A 3q95A-1yz6A:
undetectable		 3q95A-1yz6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 198
ILE A 251
PHE A 216
LEU A 260
ILE A 243
 None
 1.06A 3qfxA-1yz6A:
undetectable		 3qfxA-1yz6A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 198
ILE A 251
PHE A 216
LEU A 260
ILE A 243
 None
 1.04A 3qfxB-1yz6A:
undetectable		 3qfxB-1yz6A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 198
ILE A 251
PHE A 216
LEU A 260
ILE A 243
 None
 1.05A 4km0B-1yz6A:
undetectable		 4km0B-1yz6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ALA A 206
VAL A 214
GLU A 213
ASP A 179
ILE A 226
 None
 1.16A 5i3cB-1yz6A:
undetectable		 5i3cB-1yz6A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 GLN A  62
VAL A  19
GLU A  60
ILE A  22
 None
 1.33A 5jncA-1yz6A:
0.0		 5jncA-1yz6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 151
VAL A 125
LEU A 129
ILE A 166
LEU A 114
 None
 1.09A 5og9B-1yz6A:
undetectable		 5og9B-1yz6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.81A 5vkqA-1yz6A:
undetectable
5vkqD-1yz6A:
undetectable		 5vkqA-1yz6A:
9.42
5vkqD-1yz6A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.80A 5vkqA-1yz6A:
undetectable
5vkqB-1yz6A:
undetectable		 5vkqA-1yz6A:
9.42
5vkqB-1yz6A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.80A 5vkqB-1yz6A:
undetectable
5vkqC-1yz6A:
undetectable		 5vkqB-1yz6A:
9.42
5vkqC-1yz6A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.80A 5vkqC-1yz6A:
undetectable
5vkqD-1yz6A:
undetectable		 5vkqC-1yz6A:
9.42
5vkqD-1yz6A:
9.42