SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ALA A 180
LEU A 260
ALA A 258
ILE A 247
PHE A 216
 None
 1.09A 3fl9F-1yz7A:
undetectable		 3fl9F-1yz7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 ALA A 121
VAL A 125
LEU A 129
LEU A 106
 None
 0.75A 3roxA-1yz7A:
undetectable		 3roxA-1yz7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 ARG A 225
ILE A 243
PHE A 216
THR A 177
 None
 1.11A 4mmcA-1yz7A:
undetectable		 4mmcA-1yz7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.76A 5vkqA-1yz7A:
2.5
5vkqD-1yz7A:
2.7		 5vkqA-1yz7A:
7.27
5vkqD-1yz7A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.75A 5vkqA-1yz7A:
2.7
5vkqB-1yz7A:
2.7		 5vkqA-1yz7A:
7.27
5vkqB-1yz7A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.75A 5vkqB-1yz7A:
2.7
5vkqC-1yz7A:
2.7		 5vkqB-1yz7A:
7.27
5vkqC-1yz7A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 LEU A 107
LYS A 108
ALA A 111
LEU A 114
 None
 0.75A 5vkqC-1yz7A:
2.6
5vkqD-1yz7A:
2.7		 5vkqC-1yz7A:
7.27
5vkqD-1yz7A:
7.27