SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 LEU A 109
SER A 104
ASN A 143
 None
 0.72A 1bx4A-1yzfA:
3.0		 1bx4A-1yzfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A  74
LEU A 178
LEU A  24
 None
 0.64A 1mx1E-1yzfA:
2.2		 1mx1E-1yzfA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 4 ALA A  13
VAL A  20
ALA A  19
HIS A 169
 None
 1.16A 1q23F-1yzfA:
undetectable		 1q23F-1yzfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 THR A  12
ASP A  79
SER A  81
 None
 0.57A 2nxeA-1yzfA:
undetectable		 2nxeA-1yzfA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 THR A  12
ASP A  79
SER A  81
 None
 0.55A 2nxeB-1yzfA:
undetectable		 2nxeB-1yzfA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 6 ASP A  50
LEU A  56
ASP A  79
LEU A 131
 None
 1.19A 3bj8C-1yzfA:
undetectable
3bj8D-1yzfA:
undetectable		 3bj8C-1yzfA:
25.48
3bj8D-1yzfA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 THR A  87
ASP A  54
GLY A  49
SER A  10
ASN A  94
 None
 1.17A 3hiiA-1yzfA:
0.0		 3hiiA-1yzfA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 THR A  87
ASP A  54
GLY A  49
SER A  10
ASN A  94
 None
 1.17A 3hiiB-1yzfA:
0.0		 3hiiB-1yzfA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.23A 3sxjA-1yzfA:
2.8		 3sxjA-1yzfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.23A 3sxjB-1yzfA:
2.9		 3sxjB-1yzfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.24A 3t7sA-1yzfA:
3.0		 3t7sA-1yzfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.22A 3t7sB-1yzfA:
2.9		 3t7sB-1yzfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.25A 3t7sC-1yzfA:
2.9		 3t7sC-1yzfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ARG A  92
GLY A 139
GLU A 137
ALA A 140
ASN A 143
 None
 1.24A 3t7sD-1yzfA:
2.5		 3t7sD-1yzfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ASP A 160
GLY A 167
GLY A 118
HIS A 169
ASP A 166
 None
 1.15A 4blvA-1yzfA:
3.0		 4blvA-1yzfA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 GLY A 167
GLY A 118
HIS A 169
ASP A 166
PRO A 113
 None
 1.08A 4blvA-1yzfA:
3.0		 4blvA-1yzfA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A 162
VAL A 132
ILE A 128
 None
 0.56A 4emaA-1yzfA:
undetectable		 4emaA-1yzfA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ASP A  79
ILE A 128
ILE A 110
VAL A  72
ILE A 182
 None
 1.01A 4q5mA-1yzfA:
undetectable		 4q5mA-1yzfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 6 SER A 171
GLY A 158
GLU A 161
ASP A 160
 None
 1.01A 4uckB-1yzfA:
2.1		 4uckB-1yzfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ASP A  83
LEU A  82
HIS A 169
LEU A 168
PRO A 124
 None
 1.33A 4xi3A-1yzfA:
undetectable		 4xi3A-1yzfA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 8 LEU A 181
ASP A 148
ALA A 152
VAL A 155
 None
 0.89A 4zbqA-1yzfA:
1.3		 4zbqA-1yzfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 5 ARG A 189
ILE A 108
GLY A 139
LEU A 109
 None
 0.88A 5dzki-1yzfA:
undetectable
5dzkj-1yzfA:
undetectable
5dzkx-1yzfA:
undetectable		 5dzki-1yzfA:
22.90
5dzkj-1yzfA:
22.90
5dzkx-1yzfA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		4 / 8 SER A  81
ASP A  83
SER A  10
ASN A  78
 None
 1.06A 5l1fA-1yzfA:
3.3
5l1fB-1yzfA:
4.6		 5l1fA-1yzfA:
14.41
5l1fB-1yzfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		5 / 12 ALA A 135
LEU A 144
LEU A 109
ILE A 108
ILE A 110
 None
 1.25A 5uanB-1yzfA:
undetectable		 5uanB-1yzfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A   7
ASP A   9
LEU A  27
 None
 0.70A 5uhbC-1yzfA:
undetectable		 5uhbC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A   7
ASP A   9
LEU A 181
 None
 0.79A 5uhbC-1yzfA:
undetectable		 5uhbC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A   7
ASP A   9
LEU A  27
 None
 0.73A 5uhcC-1yzfA:
undetectable		 5uhcC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 PHE A   7
ASP A   9
LEU A 181
 None
 0.77A 5uhcC-1yzfA:
undetectable		 5uhcC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1yzf LIPASE/ACYLHYDROLASE
(Enterococcus
faecalis) 		3 / 3 VAL A  71
GLU A  70
ILE A 102
 None
 0.60A 6f7lB-1yzfA:
2.3		 6f7lB-1yzfA:
19.91