SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ASN A  37
ASN A  64
ILE A  66
LEU A  93
VAL A  21
 None
 1.08A 1r30A-1yzhA:
undetectable		 1r30A-1yzhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ASN A  37
ASN A  64
ILE A  66
LEU A  93
VAL A  21
 None
 1.08A 1r30B-1yzhA:
undetectable		 1r30B-1yzhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  46
GLY A  48
ILE A  70
PHE A 116
THR A 191
 None
 0.55A 2vdvE-1yzhA:
17.5		 2vdvE-1yzhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  46
GLY A  48
PHE A 116
ASP A 118
THR A 191
 None
 0.76A 2vdvE-1yzhA:
17.5		 2vdvE-1yzhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  46
GLY A  48
ILE A  70
PHE A 116
THR A 191
 None
 0.55A 2vdvF-1yzhA:
17.6		 2vdvF-1yzhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  46
GLY A  48
PHE A 116
ASP A 118
THR A 191
 None
 0.75A 2vdvF-1yzhA:
17.6		 2vdvF-1yzhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 7 TYR A  19
GLY A  50
ALA A  78
LEU A  75
SER A  54
 None
 1.45A 2wekB-1yzhA:
5.6		 2wekB-1yzhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  46
GLY A  48
ILE A  70
ASP A 118
THR A 191
 None
 0.72A 3ckkA-1yzhA:
18.5		 3ckkA-1yzhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		6 / 11 GLU A  44
GLY A  46
GLY A  48
ILE A  68
PHE A 116
ASP A 118
 None
 0.53A 3dxyA-1yzhA:
22.8		 3dxyA-1yzhA:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 THR A 131
LEU A 130
LEU A 114
THR A 153
 None
 0.90A 4z90A-1yzhA:
undetectable
4z90B-1yzhA:
undetectable
4z90C-1yzhA:
undetectable
4z90D-1yzhA:
undetectable
4z90E-1yzhA:
undetectable		 4z90A-1yzhA:
21.76
4z90B-1yzhA:
21.76
4z90C-1yzhA:
21.76
4z90D-1yzhA:
21.76
4z90E-1yzhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 127
ARG A 128
HIS A 125
 None
 1.15A 4zbrA-1yzhA:
undetectable		 4zbrA-1yzhA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A 110
HIS A  42
ARG A 111
ILE A  63
 None
 1.20A 5a06A-1yzhA:
4.5		 5a06A-1yzhA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  46
ASP A  69
ILE A  70
VAL A  74
LEU A 130
 None
 0.87A 6bq4A-1yzhA:
11.0		 6bq4A-1yzhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 VAL A  87
ASN A  89
ASN A  60
PRO A  61
 None
 1.15A 6h7uA-1yzhA:
undetectable		 6h7uA-1yzhA:
19.04