SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B25_A_SAMA601_0 (HYPOTHETICAL PROTEIN)	1yzn	GTP-BINDING PROTEIN YPT1 (Saccharomyces cerevisiae)	5 / 12	THR A 40 GLY A 20 GLY A 18 GLY A 66 ASP A 124	MG A 301 ( 3.1A) GNP A 300 (-3.3A) GNP A 300 (-3.7A) GNP A 300 (-3.1A) GNP A 300 (-2.9A)	1.02A	2b25A-1yznA: 2.5	2b25A-1yznA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYR_B_SVRB401_3 (NAD-DEPENDENT DEACETYLASE SIRTUIN-5)	1yzn	GTP-BINDING PROTEIN YPT1 (Saccharomyces cerevisiae)	5 / 12	TYR A 78 ILE A 84 GLY A 98 VAL A 119 TYR A 88	None	1.40A	2nyrB-1yznA: 4.3	2nyrB-1yznA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QB4_A_DSMA801_1 (TRANSPORTER)	1yzn	GTP-BINDING PROTEIN YPT1 (Saccharomyces cerevisiae)	5 / 12	GLN A 168 ILE A 61 ALA A 161 PHE A 162 LEU A 13	None	1.04A	2qb4A-1yznA: undetectable	2qb4A-1yznA: 17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QJU_A_DSMA801_1 (TRANSPORTER)	1yzn	GTP-BINDING PROTEIN YPT1 (Saccharomyces cerevisiae)	5 / 11	GLN A 168 ILE A 61 ALA A 161 PHE A 162 LEU A 13	None	1.11A	2qjuA-1yznA: undetectable	2qjuA-1yznA: 17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KMO_A_EAAA214_1 (GLUTATHIONE S-TRANSFERASE P)	1yzn	GTP-BINDING PROTEIN YPT1 (Saccharomyces cerevisiae)	5 / 9	VAL A 87 GLY A 120 GLN A 67 ASN A 121 GLY A 20	None None None GNP A 300 (-3.2A) GNP A 300 (-3.3A)	1.39A	3kmoA-1yznA: undetectable	3kmoA-1yznA: 24.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2B25_A_SAMA601_0","HYPOTHETICAL PROTEIN","1yzn","GTP-BINDING PROTEIN YPT1","Saccharomyces cerevisiae",5,"THR A  40;GLY A  20;GLY A  18;GLY A  66;ASP A 124"," MG A 301 ( 3.1A);GNP A 300 (-3.3A);GNP A 300 (-3.7A);GNP A 300 (-3.1A);GNP A 300 (-2.9A)","1.02A","2b25A-1yznA:2.5","2b25A-1yznA:21.60"],["2NYR_B_SVRB401_3","NAD-DEPENDENT DEACETYLASE SIRTUIN-5","1yzn","GTP-BINDING PROTEIN YPT1","Saccharomyces cerevisiae",5,"TYR A  78;ILE A  84;GLY A  98;VAL A 119;TYR A  88","None","1.40A","2nyrB-1yznA:4.3","2nyrB-1yznA:22.22"],["2QB4_A_DSMA801_1","TRANSPORTER","1yzn","GTP-BINDING PROTEIN YPT1","Saccharomyces cerevisiae",5,"GLN A 168;ILE A  61;ALA A 161;PHE A 162;LEU A  13","None","1.04A","2qb4A-1yznA:undetectable","2qb4A-1yznA:17.12"],["2QJU_A_DSMA801_1","TRANSPORTER","1yzn","GTP-BINDING PROTEIN YPT1","Saccharomyces cerevisiae",5,"GLN A 168;ILE A  61;ALA A 161;PHE A 162;LEU A  13","None","1.11A","2qjuA-1yznA:undetectable","2qjuA-1yznA:17.25"],["3KMO_A_EAAA214_1","GLUTATHIONE S-TRANSFERASE P","1yzn","GTP-BINDING PROTEIN YPT1","Saccharomyces cerevisiae",5,"VAL A  87;GLY A 120;GLN A  67;ASN A 121;GLY A  20","None;None;None;GNP A 300 (-3.2A);GNP A 300 (-3.3A)","1.39A","3kmoA-1yznA:undetectable","3kmoA-1yznA:24.36"]]