SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 PHE A 190
LEU A 170
SER A 241
 HEM  A 396 (-4.9A)
HEM  A 396 (-4.8A)
HEM  A 396 ( 3.7A)
 0.79A 1e7aA-1yzpA:
undetectable		 1e7aA-1yzpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		5 / 12 HIS A 173
SER A 172
ILE A  41
LEU A  24
GLY A  34
 HEM  A 396 (-3.3A)
HEM  A 396 (-2.8A)
HEM  A 396 ( 3.8A)
None
None
 1.15A 1tlsB-1yzpA:
undetectable		 1tlsB-1yzpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		5 / 12 ALA A 102
GLN A 107
GLY A  62
LEU A 279
LEU A  69
 None
None
CA  A 372 (-4.4A)
None
None
 1.38A 2nv4B-1yzpA:
undetectable		 2nv4B-1yzpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 5 ALA A  37
ALA A 120
GLN A  25
VAL A 293
 None
 0.74A 2nyrB-1yzpA:
undetectable		 2nyrB-1yzpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 6 ILE A  28
PRO A 356
LEU A  68
ILE A  91
 None
 0.93A 2q83B-1yzpA:
undetectable		 2q83B-1yzpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.97A 2v2gA-1yzpA:
undetectable
2v2gB-1yzpA:
undetectable		 2v2gA-1yzpA:
20.83
2v2gB-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.95A 2v2gA-1yzpA:
undetectable
2v2gB-1yzpA:
undetectable		 2v2gA-1yzpA:
20.83
2v2gB-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.96A 2v2gC-1yzpA:
undetectable
2v2gD-1yzpA:
undetectable		 2v2gC-1yzpA:
20.83
2v2gD-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.98A 2v2gC-1yzpA:
undetectable
2v2gD-1yzpA:
undetectable		 2v2gC-1yzpA:
20.83
2v2gD-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.94A 2v32A-1yzpA:
undetectable
2v32B-1yzpA:
undetectable		 2v32A-1yzpA:
20.83
2v32B-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.96A 2v32A-1yzpA:
undetectable
2v32B-1yzpA:
undetectable		 2v32A-1yzpA:
20.83
2v32B-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.97A 2v32C-1yzpA:
undetectable
2v32D-1yzpA:
undetectable		 2v32C-1yzpA:
20.83
2v32D-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 THR A 193
PRO A 194
VAL A 175
SER A 174
 CA  A 371 (-3.6A)
None
None
CA  A 371 (-2.4A)
 0.99A 2v32C-1yzpA:
undetectable
2v32D-1yzpA:
undetectable		 2v32C-1yzpA:
20.83
2v32D-1yzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		5 / 12 HIS A 281
GLY A 280
GLY A  60
ILE A 134
LEU A 279
 None
 0.83A 2x1lB-1yzpA:
undetectable		 2x1lB-1yzpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		5 / 12 ALA A 127
VAL A   9
ASP A 291
GLY A 128
ILE A 287
 None
 1.42A 3a65A-1yzpA:
undetectable		 3a65A-1yzpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		5 / 8 ASP A 314
GLY A 311
PHE A 306
VAL A 259
GLN A 200
 None
 1.48A 4acbB-1yzpA:
undetectable
4acbC-1yzpA:
undetectable		 4acbB-1yzpA:
22.31
4acbC-1yzpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 VAL A 137
ALA A 135
PHE A  77
 None
 0.65A 4olbA-1yzpA:
undetectable		 4olbA-1yzpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 PHE A  45
SER A 172
ALA A 272
LEU A 276
 HEM  A 396 (-3.6A)
HEM  A 396 (-2.8A)
None
None
 1.01A 4rkuA-1yzpA:
undetectable
4rkuJ-1yzpA:
undetectable		 4rkuA-1yzpA:
20.80
4rkuJ-1yzpA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 VAL A 137
ALA A 135
PHE A  77
 None
 0.66A 4w5nA-1yzpA:
undetectable		 4w5nA-1yzpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 PHE A  45
SER A 172
ALA A 272
LEU A 276
 HEM  A 396 (-3.6A)
HEM  A 396 (-2.8A)
None
None
 0.97A 4xk8A-1yzpA:
0.0		 4xk8A-1yzpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 PHE A  45
SER A 172
ALA A 272
LEU A 276
 HEM  A 396 (-3.6A)
HEM  A 396 (-2.8A)
None
None
 0.98A 4xk8a-1yzpA:
undetectable		 4xk8a-1yzpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 LEU A 126
VAL A 292
ASP A 291
 None
 0.55A 4y8wC-1yzpA:
0.5		 4y8wC-1yzpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 VAL A 137
ALA A 135
PHE A  77
 None
 0.65A 4z4iA-1yzpA:
undetectable		 4z4iA-1yzpA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 ASN A 260
LEU A 315
PHE A 202
 None
 0.80A 5dsgA-1yzpA:
undetectable		 5dsgA-1yzpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 VAL A 137
ALA A 135
PHE A  77
 None
 0.64A 5js1A-1yzpA:
undetectable		 5js1A-1yzpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 8 SER A  52
ALA A 136
ASP A  64
SER A  66
 None
None
CA  A 372 (-3.1A)
CA  A 372 (-2.4A)
 1.08A 5l5fY-1yzpA:
undetectable
5l5fZ-1yzpA:
undetectable		 5l5fY-1yzpA:
19.61
5l5fZ-1yzpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		3 / 3 THR A  44
PRO A 121
ARG A 122
 None
 0.72A 5nd7B-1yzpA:
undetectable		 5nd7B-1yzpA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 5 ARG A  42
HIS A  46
ALA A  79
PRO A 144
 HEM  A 396 (-4.0A)
None
None
HEM  A 396 (-4.2A)
 0.99A 5syiA-1yzpA:
24.1		 5syiA-1yzpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 ALA A 135
GLU A  74
ASP A  84
ILE A  91
 None
CA  A 372 ( 4.3A)
None
None
 0.92A 6fbnA-1yzpA:
undetectable		 6fbnA-1yzpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1yzp PEROXIDASE
MANGANESE-DEPENDENT
I
(Phanerochaete
chrysosporium) 		4 / 7 GLY A  60
HIS A  46
GLU A 143
GLY A 139
 None
 0.97A 6n7fA-1yzpA:
undetectable		 6n7fA-1yzpA:
15.97