SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		5 / 12 LEU A  44
THR A  13
ASP A 178
GLY A   9
HIS A   7
 None
 1.50A 1v8bA-1yzvA:
3.3		 1v8bA-1yzvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		5 / 12 LEU A  44
THR A  13
ASP A 178
GLY A   9
HIS A   7
 None
 1.49A 1v8bB-1yzvA:
3.3		 1v8bB-1yzvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		5 / 12 LEU A  44
THR A  13
ASP A 178
GLY A   9
HIS A   7
 None
 1.48A 1v8bC-1yzvA:
3.3		 1v8bC-1yzvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		3 / 3 LEU A 123
LEU A   5
PHE A  16
 None
 0.68A 2pgrA-1yzvA:
undetectable		 2pgrA-1yzvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 4 GLY A  49
LEU A 173
PHE A 181
ILE A 184
 None
 0.99A 4xv2A-1yzvA:
undetectable		 4xv2A-1yzvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 7 LEU A 151
LEU A 117
ALA A 120
ALA A 121
 None
 0.89A 6a7jA-1yzvA:
undetectable		 6a7jA-1yzvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 7 ALA A 133
THR A 164
GLN A 104
VAL A 106
 None
 0.92A 6cduA-1yzvA:
undetectable
6cduE-1yzvA:
undetectable		 6cduA-1yzvA:
21.36
6cduE-1yzvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 7 GLN A 104
VAL A 106
ALA A 133
THR A 164
 None
 0.96A 6cduC-1yzvA:
undetectable
6cduD-1yzvA:
undetectable		 6cduC-1yzvA:
21.36
6cduD-1yzvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 7 ALA A 133
THR A 164
GLN A 104
VAL A 106
 None
 0.95A 6cduF-1yzvA:
undetectable
6cduJ-1yzvA:
undetectable		 6cduF-1yzvA:
21.36
6cduJ-1yzvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1yzv HYPOTHETICAL PROTEIN
(Trypanosoma
cruzi) 		4 / 7 GLN A 104
VAL A 106
ALA A 133
THR A 164
 None
 0.90A 6cduH-1yzvA:
undetectable
6cduI-1yzvA:
undetectable		 6cduH-1yzvA:
21.36
6cduI-1yzvA:
21.36