SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1z00 DNA EXCISION REPAIR
PROTEIN ERCC-1
(Homo
sapiens) 		4 / 5 ASP A 270
LEU A 273
ALA A 266
LEU A 263
 None
 1.17A 1nh8A-1z00A:
undetectable		 1nh8A-1z00A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1z00 DNA EXCISION REPAIR
PROTEIN ERCC-1
(Homo
sapiens) 		5 / 12 ALA A 266
PHE A 257
ARG A 283
GLY A 278
LEU A 277
 None
 1.29A 5m54E-1z00A:
undetectable		 5m54E-1z00A:
12.41