SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		4 / 5 LEU A 399
SER A  39
LEU A  41
GLY A  18
 None
 1.14A 1a4lB-1z05A:
undetectable		 1a4lB-1z05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 11 ILE A 339
LEU A 222
ILE A 272
LEU A 317
ILE A 343
 None
 1.04A 1dhiB-1z05A:
undetectable		 1dhiB-1z05A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 339
LEU A 222
ILE A 272
LEU A 317
ILE A 343
 None
 1.05A 1draB-1z05A:
undetectable		 1draB-1z05A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 299
CYH A 300
ALA A 302
ALA A 303
LEU A 288
 None
 0.57A 1fbyA-1z05A:
undetectable		 1fbyA-1z05A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 299
CYH A 300
ALA A 302
ALA A 303
LEU A 288
 None
 0.56A 1fbyB-1z05A:
undetectable		 1fbyB-1z05A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 GLU A 264
HIS A 256
HIS A 245
 None
None
ZN  A 406 (-3.2A)
 0.60A 1oe2A-1z05A:
undetectable		 1oe2A-1z05A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ALA A 183
ILE A 150
ILE A 148
LEU A  96
LEU A 124
 None
 0.92A 1xdkF-1z05A:
undetectable		 1xdkF-1z05A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 299
CYH A 300
ALA A 302
ALA A 303
LEU A 288
 None
 0.53A 1xiuA-1z05A:
undetectable		 1xiuA-1z05A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 ASP A 193
ILE A 218
VAL A 214
 SO4  A 408 ( 4.3A)
None
None
 0.69A 2avvD-1z05A:
undetectable		 2avvD-1z05A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 SER A 348
ASP A 305
CYH A 287
 GOL  A 414 (-3.3A)
None
None
 1.04A 2br4E-1z05A:
undetectable		 2br4E-1z05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 339
LEU A 222
ILE A 272
LEU A 317
ILE A 343
 None
 1.07A 2drcB-1z05A:
undetectable		 2drcB-1z05A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.74A 2iwkA-1z05A:
undetectable		 2iwkA-1z05A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.73A 2iwkB-1z05A:
undetectable		 2iwkB-1z05A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 VAL A 227
GLY A 230
ARG A 231
LYS A 202
LEU A 199
 None
 1.48A 3bexA-1z05A:
8.4
3bexB-1z05A:
8.5		 3bexA-1z05A:
22.05
3bexB-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 VAL A 227
GLY A 230
ARG A 231
LYS A 202
LEU A 203
 None
 1.44A 3bexA-1z05A:
8.4
3bexB-1z05A:
8.5		 3bexA-1z05A:
22.05
3bexB-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 9 LYS A 202
LEU A 199
VAL A 227
GLY A 230
ARG A 231
 None
 1.47A 3bexA-1z05A:
8.6
3bexB-1z05A:
8.5		 3bexA-1z05A:
22.05
3bexB-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 9 LYS A 202
LEU A 203
VAL A 227
GLY A 230
ARG A 231
 None
 1.42A 3bexA-1z05A:
8.6
3bexB-1z05A:
8.5		 3bexA-1z05A:
22.05
3bexB-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 11 VAL A 227
GLY A 230
ARG A 231
LYS A 202
LEU A 203
 None
 1.41A 3bexC-1z05A:
8.5
3bexD-1z05A:
8.5		 3bexC-1z05A:
22.05
3bexD-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 LYS A 202
LEU A 199
VAL A 227
GLY A 230
ARG A 231
 None
 1.47A 3bexC-1z05A:
9.3
3bexD-1z05A:
8.6		 3bexC-1z05A:
22.05
3bexD-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 LYS A 202
LEU A 203
VAL A 227
GLY A 230
ARG A 231
 None
 1.43A 3bexC-1z05A:
9.3
3bexD-1z05A:
8.6		 3bexC-1z05A:
22.05
3bexD-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 VAL A 227
GLY A 230
ARG A 231
LYS A 202
LEU A 199
 None
 1.47A 3bexE-1z05A:
8.6
3bexF-1z05A:
9.6		 3bexE-1z05A:
22.05
3bexF-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 VAL A 227
GLY A 230
ARG A 231
LYS A 202
LEU A 203
 None
 1.41A 3bexE-1z05A:
8.6
3bexF-1z05A:
9.6		 3bexE-1z05A:
22.05
3bexF-1z05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		4 / 5 LEU A 243
ILE A 325
ILE A 246
GLY A 241
 None
 0.85A 3bufA-1z05A:
undetectable		 3bufA-1z05A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.69A 3dtuB-1z05A:
undetectable		 3dtuB-1z05A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.66A 3dtuD-1z05A:
undetectable		 3dtuD-1z05A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 11 LEU A 108
ALA A  99
GLY A 105
SER A  88
LEU A  87
 None
 1.25A 3gyqB-1z05A:
undetectable		 3gyqB-1z05A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 ASN A  81
ASP A  25
ARG A 376
 None
 0.90A 3k13C-1z05A:
undetectable		 3k13C-1z05A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		3 / 3 GLY A 223
ILE A 327
VAL A 328
 None
 0.27A 3nv6A-1z05A:
undetectable		 3nv6A-1z05A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 9 ILE A 218
GLY A 244
ILE A 246
ILE A 325
ILE A 216
 None
 1.02A 3s45A-1z05A:
undetectable		 3s45A-1z05A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 ILE A 339
LEU A 222
ILE A 272
LEU A 317
ILE A 343
 None
 1.07A 4dfrB-1z05A:
undetectable		 4dfrB-1z05A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  53
SER A  45
ILE A  46
ARG A  32
LEU A  35
 None
None
None
SO4  A 411 ( 4.7A)
None
 1.16A 4qi9B-1z05A:
undetectable		 4qi9B-1z05A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 8 ALA A 324
ALA A 326
ILE A 327
PHE A 332
LEU A 331
 None
 1.25A 4v1fA-1z05A:
undetectable
4v1fB-1z05A:
undetectable		 4v1fA-1z05A:
12.26
4v1fB-1z05A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A 128
ILE A  98
GLU A 117
VAL A 145
LEU A 142
 None
 1.10A 4y0qA-1z05A:
undetectable		 4y0qA-1z05A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		4 / 4 VAL A 190
ALA A 191
ASN A 192
GLN A 234
 None
 1.30A 4zgfA-1z05A:
undetectable		 4zgfA-1z05A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 10 ALA A 324
ILE A 248
GLY A 223
LEU A 222
ALA A 267
 None
 1.10A 5ajqB-1z05A:
undetectable		 5ajqB-1z05A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A 124
GLN A 120
VAL A 171
LEU A 152
GLY A 161
 None
 1.27A 5i8fA-1z05A:
0.0		 5i8fA-1z05A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		4 / 7 LEU A 321
VAL A 328
GLN A 361
GLU A 360
 None
None
BME  A 413 ( 4.8A)
BME  A 413 (-3.6A)
 1.08A 5tudA-1z05A:
undetectable		 5tudA-1z05A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY
(Vibrio
cholerae) 		4 / 5 LEU A 127
LEU A 124
MET A 166
TYR A  95
 None
None
None
SO4  A 407 (-4.6A)
 1.10A 5uc3A-1z05A:
undetectable		 5uc3A-1z05A:
10.50