SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 PHE A  58
LEU A  49
SER A 178
 GNP  A 204 (-4.6A)
None
GNP  A 204 (-3.2A)
 0.73A 1e7aA-1z06A:
undetectable		 1e7aA-1z06A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 1.04A 1qomA-1z06A:
undetectable		 1qomA-1z06A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 1.13A 2nodB-1z06A:
undetectable		 2nodB-1z06A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 1.20A 3e6tB-1z06A:
undetectable		 3e6tB-1z06A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 1.11A 3e7iB-1z06A:
undetectable		 3e7iB-1z06A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 CYH A  54
PRO A  59
ASP A  88
 None
None
MG  A 203 ( 3.8A)
 0.86A 3hlwB-1z06A:
undetectable		 3hlwB-1z06A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		5 / 9 VAL A 113
GLY A 147
GLN A  92
ASN A 148
GLY A  45
 None
None
None
GNP  A 204 (-3.3A)
GNP  A 204 (-3.1A)
 1.44A 3kmoA-1z06A:
undetectable		 3kmoA-1z06A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		5 / 11 ARG A  96
VAL A 107
ILE A 141
ILE A 129
ILE A  37
 None
 1.03A 3lzvB-1z06A:
undetectable		 3lzvB-1z06A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 0.97A 3nw2A-1z06A:
undetectable		 3nw2A-1z06A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 ARG A 105
ILE A  37
TRP A  87
 None
 1.04A 3nw2B-1z06A:
undetectable		 3nw2B-1z06A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 CYH A  54
PRO A  59
ASP A  88
 None
None
MG  A 203 ( 3.8A)
 0.88A 4pm5A-1z06A:
undetectable		 4pm5A-1z06A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		4 / 7 THR A  62
ALA A  64
THR A  65
ALA A  90
 GNP  A 204 (-3.6A)
GNP  A 204 (-3.6A)
MG  A 203 ( 3.1A)
None
 0.97A 4qw0K-1z06A:
undetectable		 4qw0K-1z06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		4 / 7 THR A  62
ALA A  64
THR A  65
ALA A  90
 GNP  A 204 (-3.6A)
GNP  A 204 (-3.6A)
MG  A 203 ( 3.1A)
None
 0.97A 4qw0Y-1z06A:
undetectable		 4qw0Y-1z06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		4 / 4 ILE A  37
ARG A  96
TYR A 104
GLU A 131
 None
 1.23A 4zzbD-1z06A:
undetectable		 4zzbD-1z06A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 THR A  47
THR A  50
PHE A  70
 MG  A 203 ( 3.0A)
None
None
 0.85A 5cxvA-1z06A:
undetectable		 5cxvA-1z06A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		5 / 9 ILE A 129
ASP A  41
GLY A  40
PHE A 112
ALA A 120
 None
 1.41A 5x66C-1z06A:
undetectable		 5x66C-1z06A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		5 / 10 ILE A 129
ASP A  41
GLY A  40
PHE A 112
ALA A 120
 None
 1.38A 5x66D-1z06A:
undetectable		 5x66D-1z06A:
19.80