SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 ASP A  61
THR A  27
LEU A  24
LEU A  23
 MG  A1201 (-3.0A)
None
None
None
 1.19A 1u18B-1z0aA:
undetectable		 1u18B-1z0aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 6 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.15A 3vqrA-1z0aA:
undetectable		 3vqrA-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.16A 3vqrB-1z0aA:
2.3		 3vqrB-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		3 / 3 ARG A 126
LYS A 120
ARG A  90
 None
GDP  A1200 (-3.4A)
None
 1.44A 3w1wA-1z0aA:
0.4
3w1wB-1z0aA:
0.5		 3w1wA-1z0aA:
19.47
3w1wB-1z0aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		3 / 3 ARG A  90
ARG A 126
LYS A 120
 None
None
GDP  A1200 (-3.4A)
 1.38A 3w1wA-1z0aA:
0.4
3w1wB-1z0aA:
0.5		 3w1wA-1z0aA:
19.47
3w1wB-1z0aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 9 TYR A   9
PHE A  26
ILE A 117
MET A 146
 None
 1.13A 4jvlA-1z0aA:
undetectable		 4jvlA-1z0aA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 7 ALA A 159
ASP A  61
GLY A  13
GLU A  66
 None
MG  A1201 (-3.0A)
None
GDP  A1200 ( 4.8A)
 0.99A 5bs8A-1z0aA:
undetectable
5bs8B-1z0aA:
3.9
5bs8C-1z0aA:
undetectable		 5bs8A-1z0aA:
14.51
5bs8B-1z0aA:
24.80
5bs8C-1z0aA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.23A 5hm8A-1z0aA:
4.2		 5hm8A-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.24A 5hm8B-1z0aA:
2.6		 5hm8B-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.23A 5hm8C-1z0aA:
4.2		 5hm8C-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.24A 5hm8D-1z0aA:
2.6		 5hm8D-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.24A 5hm8E-1z0aA:
undetectable		 5hm8E-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.24A 5hm8F-1z0aA:
2.7		 5hm8F-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.27A 5hm8G-1z0aA:
undetectable		 5hm8G-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.24A 5hm8H-1z0aA:
3.1		 5hm8H-1z0aA:
17.62