SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 PHE A  33
LEU A  24
SER A 151
 GTP  A1200 (-4.4A)
None
GTP  A1200 (-3.5A)
 0.74A 1e7aA-1z0kA:
undetectable		 1e7aA-1z0kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 103
LEU A  99
VAL A 131
TYR A  96
ILE A 116
 None
 1.14A 1s9pA-1z0kA:
undetectable		 1s9pA-1z0kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 PHE A   9
VAL A  52
GLY A  53
ILE A 169
 None
 0.78A 2a1mB-1z0kA:
undetectable		 2a1mB-1z0kA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A1201 ( 3.1A)
GTP  A1200 (-3.3A)
GTP  A1200 (-3.6A)
GTP  A1200 (-3.5A)
GTP  A1200 (-2.9A)
 0.99A 2b25A-1z0kA:
undetectable		 2b25A-1z0kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  15
ALA A  98
VAL A  13
PHE A  70
 GTP  A1200 (-3.5A)
None
None
None
None
 1.18A 2yvlD-1z0kA:
undetectable		 2yvlD-1z0kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1z0k GTP-BINDING PROTEIN
FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASN B 488
ALA B 473
GLY A  46
THR A  40
 None
None
None
MG  A1201 ( 3.1A)
 0.88A 3dl9A-1z0kB:
undetectable		 3dl9A-1z0kB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.10A 3g88A-1z0kA:
2.1		 3g88A-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.09A 3g88B-1z0kA:
2.3		 3g88B-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.08A 3g8bB-1z0kA:
undetectable		 3g8bB-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		4 / 5 ARG A 138
LEU A 118
ARG A  93
ILE A  90
 None
 1.22A 3ln1D-1z0kA:
0.0		 3ln1D-1z0kA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 9 ASP A 157
ALA A 161
ARG A 167
ILE A 117
PHE A 147
 None
 1.50A 4oknB-1z0kA:
5.3		 4oknB-1z0kA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1z0k FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5
GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 11 ILE B 466
PHE B 469
SER A  22
TYR A  77
THR B 484
 None
None
MG  A1201 ( 2.2A)
None
None
 1.40A 4p68A-1z0kB:
undetectable		 4p68A-1z0kB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  12
LEU A  59
PHE A 162
VAL A  87
 None
 1.03A 4udaA-1z0kA:
undetectable		 4udaA-1z0kA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 1z0k FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5
(Homo
sapiens) 		5 / 9 GLN B 462
PHE B 469
GLU B 487
ILE B 470
ALA B 473
 None
 1.44A 5entC-1z0kB:
undetectable		 5entC-1z0kB:
9.89