SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.91A 1igxA-1z0uA:
undetectable		 1igxA-1z0uA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.34A 1mj2B-1z0uA:
undetectable		 1mj2B-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.41A 1mj2D-1z0uA:
undetectable		 1mj2D-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.38A 1mjoB-1z0uA:
undetectable		 1mjoB-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.35A 1mjoA-1z0uA:
undetectable		 1mjoA-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.36A 1mjoD-1z0uA:
undetectable		 1mjoD-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 8 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.81A 1ya4A-1z0uA:
2.5		 1ya4A-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 7 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.91A 1ya4B-1z0uA:
2.3		 1ya4B-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.90A 1ya4C-1z0uA:
2.5		 1ya4C-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A  51
GLY A  48
GLY A  74
LYS A 244
ILE A  55
 SO4  A 701 (-2.9A)
NAP  A3076 ( 3.7A)
NAP  A3076 ( 4.9A)
None
None
 1.42A 2akeA-1z0uA:
undetectable		 2akeA-1z0uA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 6 ASP A 135
THR A 221
GLU A 198
GLU A 223
 None
 1.35A 2dttB-1z0uA:
undetectable
2dttC-1z0uA:
undetectable		 2dttB-1z0uA:
17.08
2dttC-1z0uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  75
LEU A  76
ASP A  49
ILE A 248
 NAP  A3076 (-4.3A)
None
NAP  A3076 (-4.2A)
None
 1.09A 2rlfB-1z0uA:
undetectable
2rlfC-1z0uA:
undetectable		 2rlfB-1z0uA:
14.69
2rlfC-1z0uA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 178
ILE A 177
PRO A 188
TYR A 189
 None
 1.21A 3d9lA-1z0uA:
undetectable
3d9lY-1z0uA:
undetectable		 3d9lA-1z0uA:
18.35
3d9lY-1z0uA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
 None
 1.06A 4aztA-1z0uA:
undetectable		 4aztA-1z0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 197
LEU A 132
ILE A 175
GLY A 146
 None
 0.79A 4hb8A-1z0uA:
undetectable		 4hb8A-1z0uA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 145
ALA A 159
TYR A 158
SER A 161
GLY A 163
 None
None
NAP  A3076 (-3.4A)
NAP  A3076 (-2.3A)
None
 1.27A 4mmaA-1z0uA:
undetectable		 4mmaA-1z0uA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 120
PHE A 216
ILE A 128
 None
 0.73A 5dzk1-1z0uA:
undetectable
5dzkF-1z0uA:
undetectable
5dzkM-1z0uA:
undetectable		 5dzk1-1z0uA:
1.90
5dzkF-1z0uA:
21.80
5dzkM-1z0uA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A 234
HIS A  78
ASP A  49
GLY A  48
 None
None
NAP  A3076 (-4.2A)
NAP  A3076 ( 3.7A)
 1.10A 5x7pA-1z0uA:
undetectable		 5x7pA-1z0uA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.09A 6ebpB-1z0uA:
undetectable		 6ebpB-1z0uA:
16.30