SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1z14 VP2
(Rodent
protoparvovirus
1) 		4 / 5 LEU A 429
HIS A 442
ILE A 435
PHE A 447
 None
 0.98A 1xf1A-1z14A:
undetectable		 1xf1A-1z14A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1z14 VP2
(Rodent
protoparvovirus
1) 		5 / 12 ILE A 468
MET A 533
ARG A 580
LEU A 123
ILE A 131
 None
 1.01A 1y0xX-1z14A:
undetectable		 1y0xX-1z14A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1z14 VP2
(Rodent
protoparvovirus
1) 		5 / 11 THR A 454
ALA A 360
ILE A 362
ASP A 367
ALA A 370
 None
 1.33A 2admA-1z14A:
undetectable		 2admA-1z14A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1z14 VP2
(Rodent
protoparvovirus
1) 		3 / 3 ASN A 235
ASP A 101
ARG A  83
 None
 0.86A 3k13C-1z14A:
undetectable		 3k13C-1z14A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1z14 VP2
(Rodent
protoparvovirus
1) 		5 / 9 VAL A  61
LEU A 123
ILE A 131
ALA A  65
THR A  51
 None
 1.14A 3mdvA-1z14A:
undetectable		 3mdvA-1z14A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1z14 VP2
(Rodent
protoparvovirus
1) 		3 / 3 PRO A 110
THR A 109
LEU A 498
 None
 0.72A 3ttrA-1z14A:
undetectable		 3ttrA-1z14A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1z14 VP2
(Rodent
protoparvovirus
1) 		3 / 3 TYR A 130
GLN A 548
TRP A 128
 None
 0.89A 4kn2C-1z14A:
undetectable		 4kn2C-1z14A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1z14 VP2
(Rodent
protoparvovirus
1) 		3 / 3 LEU A 258
LEU A  73
ASN A 504
 None
 0.75A 4otwA-1z14A:
undetectable		 4otwA-1z14A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1z14 VP2
(Rodent
protoparvovirus
1) 		4 / 6 TYR A 376
ASP A 399
ILE A 578
TYR A 558
 None
 1.32A 5igyA-1z14A:
undetectable		 5igyA-1z14A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1z14 VP2
(Rodent
protoparvovirus
1) 		4 / 7 GLN A 465
GLY A 120
TRP A 128
ASP A 115
 None
 1.11A 5vlmE-1z14A:
undetectable		 5vlmE-1z14A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1z14 VP2
(Rodent
protoparvovirus
1) 		3 / 3 PHE A 338
ARG A 407
GLN A 340
 None
 1.00A 6g1pB-1z14A:
undetectable		 6g1pB-1z14A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1z14 VP2
(Rodent
protoparvovirus
1) 		4 / 5 ARG A 534
MET A 533
THR A 532
LEU A 531
 None
 1.25A 6nknW-1z14A:
undetectable		 6nknW-1z14A:
9.82