SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 LEU A 577
ILE A 587
GLU A 583
ASP A 582
 None
 1.22A 1ditH-1z1wA:
undetectable
1ditP-1z1wA:
undetectable		 1ditH-1z1wA:
14.84
1ditP-1z1wA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ARG A 178
ILE A 212
TRP A 271
 None
 1.01A 1m8eB-1z1wA:
undetectable		 1m8eB-1z1wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 TYR A 164
GLY A 166
THR A 239
TYR A 131
ILE A  96
 None
 1.02A 1nt2A-1z1wA:
undetectable		 1nt2A-1z1wA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 GLU A 341
HIS A 269
GLU A 288
HIS A 265
GLU A 266
 None
ZN  A 800 (-3.2A)
ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.4A)
 1.49A 1o86A-1z1wA:
7.2		 1o86A-1z1wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 11 ALA A 237
ILE A 180
THR A 155
PRO A 156
ALA A 199
 None
 0.82A 1rv7A-1z1wA:
undetectable
1rv7B-1z1wA:
undetectable		 1rv7A-1z1wA:
8.98
1rv7B-1z1wA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 1v7zA-1z1wA:
undetectable		 1v7zA-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 1v7zB-1z1wA:
undetectable		 1v7zB-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 1v7zC-1z1wA:
undetectable		 1v7zC-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.87A 1v7zD-1z1wA:
undetectable		 1v7zD-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 1v7zE-1z1wA:
undetectable		 1v7zE-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.87A 1v7zF-1z1wA:
undetectable		 1v7zF-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 ALA A 231
TYR A 244
ARG A 241
TYR A 351
 None
 1.22A 2ajvH-1z1wA:
undetectable
2ajvL-1z1wA:
3.4		 2ajvH-1z1wA:
14.38
2ajvL-1z1wA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 HIS A 114
ASP A  35
ASP A 113
TYR A 161
 None
 1.28A 2lh8A-1z1wA:
undetectable		 2lh8A-1z1wA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 PRO A 739
ALA A 741
ASP A 737
ASP A 707
 None
 1.17A 2nyuB-1z1wA:
undetectable		 2nyuB-1z1wA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 ALA A 185
TYR A 172
MET A  95
HIS A 220
 None
 1.18A 2pncA-1z1wA:
undetectable		 2pncA-1z1wA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ILE A 476
ILE A 460
LEU A 321
 None
 0.50A 2prgA-1z1wA:
undetectable		 2prgA-1z1wA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 ARG A 711
ILE A 714
LEU A 757
GLY A 756
 None
 0.92A 2tsrB-1z1wA:
undetectable		 2tsrB-1z1wA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 LEU A 511
LEU A 515
PHE A 536
LEU A 503
 None
 0.98A 2vq5B-1z1wA:
undetectable		 2vq5B-1z1wA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 LEU A 770
ILE A 774
ARG A 530
VAL A 314
 None
 1.08A 2ygoA-1z1wA:
undetectable		 2ygoA-1z1wA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.85A 3a6jA-1z1wA:
undetectable		 3a6jA-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.84A 3a6jB-1z1wA:
undetectable		 3a6jB-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 3a6jC-1z1wA:
undetectable		 3a6jC-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.85A 3a6jE-1z1wA:
undetectable		 3a6jE-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.86A 3a6jF-1z1wA:
undetectable		 3a6jF-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ARG A 178
ILE A 212
TRP A 271
 None
 1.04A 3e68A-1z1wA:
undetectable		 3e68A-1z1wA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ARG A 178
ILE A 212
TRP A 271
 None
 1.01A 3e6tB-1z1wA:
undetectable		 3e6tB-1z1wA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ARG A 178
ILE A 212
TRP A 271
 None
 0.91A 3e7iB-1z1wA:
undetectable		 3e7iB-1z1wA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ARG A 178
ILE A 212
TRP A 271
 None
 0.94A 3nw2A-1z1wA:
undetectable		 3nw2A-1z1wA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 ASN A 136
ASP A 154
THR A  24
SER A 135
 None
 1.19A 3p2kC-1z1wA:
undetectable		 3p2kC-1z1wA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 ASN A 136
ASP A 154
THR A  26
SER A 135
 None
 0.95A 3p2kC-1z1wA:
undetectable		 3p2kC-1z1wA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 LEU A  34
ASP A  35
ALA A  36
TYR A   6
 None
 1.06A 3rodD-1z1wA:
undetectable		 3rodD-1z1wA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 TYR A 364
LEU A 378
LYS A 376
 None
 0.70A 3sueD-1z1wA:
undetectable		 3sueD-1z1wA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 PHE A 210
ASN A 287
PHE A 290
ALA A 291
 None
None
None
ZN  A 800 ( 4.3A)
 0.99A 3t3sF-1z1wA:
undetectable		 3t3sF-1z1wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 ILE A 548
TYR A 529
VAL A 771
PHE A 516
 None
 1.10A 4a97H-1z1wA:
1.0		 4a97H-1z1wA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 ILE A 238
ALA A 199
HIS A 220
MET A 219
 None
 1.17A 4ac9B-1z1wA:
3.1
4ac9C-1z1wA:
undetectable		 4ac9B-1z1wA:
21.13
4ac9C-1z1wA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 ILE A 238
ALA A 199
HIS A 220
MET A 219
 None
 1.23A 4acaB-1z1wA:
3.2
4acaC-1z1wA:
3.1		 4acaB-1z1wA:
21.13
4acaC-1z1wA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 8 ASN A 705
ARG A 715
TYR A 716
ARG A 711
 None
 1.21A 4ijiF-1z1wA:
1.3		 4ijiF-1z1wA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 ASP A 513
ILE A 524
PHE A 435
TYR A 416
PHE A 483
 None
 1.38A 4j03A-1z1wA:
undetectable		 4j03A-1z1wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 MET A 674
LEU A 668
LEU A 662
ILE A 656
LEU A 640
 None
 1.25A 4j26A-1z1wA:
undetectable		 4j26A-1z1wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 MET A 674
LEU A 668
LEU A 662
ILE A 656
LEU A 640
 None
 1.25A 4j26B-1z1wA:
undetectable		 4j26B-1z1wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 GLU A 620
ARG A 622
ASP A 651
ARG A 648
 None
 1.14A 4kcnA-1z1wA:
undetectable		 4kcnA-1z1wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 GLU A 620
ARG A 622
ASP A 651
ARG A 648
 None
 1.13A 4kcnB-1z1wA:
undetectable		 4kcnB-1z1wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 ASP A 311
TYR A 296
TRP A 306
 None
 1.29A 4p7nA-1z1wA:
undetectable		 4p7nA-1z1wA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 ALA A 102
HIS A 265
GLU A 266
HIS A 269
GLU A 288
 None
ZN  A 800 (-3.3A)
ZN  A 800 (-3.4A)
ZN  A 800 (-3.2A)
ZN  A 800 (-2.8A)
 0.80A 4r7lA-1z1wA:
41.6		 4r7lA-1z1wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 ALA A 102
HIS A 265
GLU A 266
HIS A 269
TRP A 281
 None
ZN  A 800 (-3.3A)
ZN  A 800 (-3.4A)
ZN  A 800 (-3.2A)
None
 0.66A 4r7lA-1z1wA:
41.6		 4r7lA-1z1wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 ILE A 509
VAL A 512
PHE A 562
HIS A 542
 None
 1.35A 4rzvA-1z1wA:
undetectable		 4rzvA-1z1wA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 TYR A 194
ARG A 257
LYS A 256
 None
SO4  A 801 (-2.5A)
SO4  A 801 (-2.5A)
 1.19A 4wq5B-1z1wA:
undetectable		 4wq5B-1z1wA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 LEU A 461
LYS A 401
PRO A 402
TYR A 364
 None
 0.86A 4z4fA-1z1wA:
3.8		 4z4fA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 LEU A 461
LYS A 401
PRO A 402
TYR A 364
 None
 0.89A 4z4gA-1z1wA:
3.0		 4z4gA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.31A 5axaA-1z1wA:
undetectable		 5axaA-1z1wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.30A 5axaC-1z1wA:
undetectable		 5axaC-1z1wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 PHE A 537
ILE A 548
ASP A 541
 None
 0.59A 5cswA-1z1wA:
undetectable		 5cswA-1z1wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 PHE A 537
ILE A 548
ASP A 541
 None
 0.73A 5cswB-1z1wA:
undetectable		 5cswB-1z1wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.26A 5hm8B-1z1wA:
undetectable		 5hm8B-1z1wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.26A 5hm8C-1z1wA:
undetectable		 5hm8C-1z1wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 5 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.26A 5hm8G-1z1wA:
undetectable		 5hm8G-1z1wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 VAL A   3
ASP A  28
GLU A   2
ASP A   7
ALA A 119
 None
 1.29A 5hnzB-1z1wA:
undetectable		 5hnzB-1z1wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		6 / 12 VAL A 125
ILE A 123
ALA A 122
VAL A 165
GLY A 166
ILE A 167
 None
 1.42A 5j2tC-1z1wA:
undetectable		 5j2tC-1z1wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 VAL A 486
VAL A 447
ARG A 359
ILE A 361
 None
 0.88A 5jw1B-1z1wA:
1.0		 5jw1B-1z1wA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 LEU A 358
GLU A 369
PHE A 370
ARG A 371
GLY A 373
 None
 1.24A 5k7uA-1z1wA:
undetectable		 5k7uA-1z1wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 VAL A 398
LYS A 404
MET A 407
 None
 1.05A 5nknA-1z1wA:
undetectable		 5nknA-1z1wA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		3 / 3 VAL A 675
LYS A 681
MET A 685
 None
 1.08A 5nknA-1z1wA:
undetectable		 5nknA-1z1wA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 LEU A 511
ASP A 514
ALA A 517
LEU A 520
 None
 1.10A 5nwvA-1z1wA:
undetectable		 5nwvA-1z1wA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 7 LEU A 461
LYS A 401
PRO A 402
TYR A 364
 None
 0.85A 5t7bA-1z1wA:
3.7		 5t7bA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.35A 5v96A-1z1wA:
undetectable		 5v96A-1z1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.33A 5v96B-1z1wA:
undetectable		 5v96B-1z1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.34A 5v96C-1z1wA:
undetectable		 5v96C-1z1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.33A 5v96D-1z1wA:
undetectable		 5v96D-1z1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		5 / 12 GLU A 288
GLU A 266
HIS A 265
PHE A 346
GLY A 230
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.4A)
ZN  A 800 (-3.3A)
None
None
 1.25A 5xipC-1z1wA:
undetectable		 5xipC-1z1wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3
(Thermoplasma
acidophilum) 		4 / 6 LEU A 358
HIS A 269
HIS A 265
GLU A 288
 None
ZN  A 800 (-3.2A)
ZN  A 800 (-3.3A)
ZN  A 800 (-2.8A)
 0.95A 6pahA-1z1wA:
undetectable		 6pahA-1z1wA:
18.03