SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1z23 CRK-ASSOCIATED
SUBSTRATE
(Rattus
norvegicus) 		4 / 6 LEU A 695
THR A 560
ALA A 557
LEU A 702
 None
 1.23A 1etb2-1z23A:
undetectable		 1etb2-1z23A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1z23 CRK-ASSOCIATED
SUBSTRATE
(Rattus
norvegicus) 		5 / 10 LEU A 561
ALA A 688
LEU A 564
ALA A 620
LEU A 617
 None
 1.21A 1ie4A-1z23A:
undetectable
1ie4C-1z23A:
undetectable		 1ie4A-1z23A:
23.21
1ie4C-1z23A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1z23 CRK-ASSOCIATED
SUBSTRATE
(Rattus
norvegicus) 		5 / 12 LEU A 575
LEU A 578
VAL A 579
SER A 581
LEU A 660
 None
 1.25A 1ie9A-1z23A:
undetectable		 1ie9A-1z23A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1z23 CRK-ASSOCIATED
SUBSTRATE
(Rattus
norvegicus) 		5 / 11 ALA A 620
LEU A 617
LEU A 561
ALA A 688
LEU A 564
 None
 1.24A 1tz8A-1z23A:
undetectable
1tz8B-1z23A:
undetectable		 1tz8A-1z23A:
21.05
1tz8B-1z23A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1z23 CRK-ASSOCIATED
SUBSTRATE
(Rattus
norvegicus) 		3 / 3 LYS A 638
LEU A 635
ALA A 637
 None
 0.73A 4ikiA-1z23A:
undetectable		 4ikiA-1z23A:
21.05