SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 TYR A 743
LEU A 530
VAL A 534
SER A 536
VAL A 505
 None
 1.30A 1db1A-1z26A:
undetectable		 1db1A-1z26A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.20A 1dhiA-1z26A:
undetectable		 1dhiA-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.23A 1dhjA-1z26A:
undetectable		 1dhjA-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.22A 1draA-1z26A:
undetectable		 1draA-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.19A 1drbA-1z26A:
undetectable		 1drbA-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 TYR A 743
LEU A 530
VAL A 534
SER A 536
VAL A 505
 None
 1.32A 1ie9A-1z26A:
undetectable		 1ie9A-1z26A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 PHE A 496
TRP A 755
GLU A 489
 None
 1.14A 1mogA-1z26A:
undetectable		 1mogA-1z26A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 133
ILE A   7
LEU A 304
VAL A 307
ILE A 312
 None
 0.89A 1oipA-1z26A:
undetectable		 1oipA-1z26A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.14A 1rd7A-1z26A:
undetectable		 1rd7A-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.20A 1rd7B-1z26A:
undetectable		 1rd7B-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 4 LEU A 277
ILE A 125
ARG A 111
TYR A 122
 None
 1.43A 1rk3A-1z26A:
0.0		 1rk3A-1z26A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.20A 1rx7A-1z26A:
undetectable		 1rx7A-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
 None
 1.17A 1tdrA-1z26A:
undetectable		 1tdrA-1z26A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 6 LEU A 304
LEU A 300
LEU A 110
LEU A 106
 None
WO4  A 773 (-4.6A)
None
None
 1.04A 2ab2A-1z26A:
undetectable		 2ab2A-1z26A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 LEU A 304
LEU A 300
LEU A 110
LEU A 106
 None
WO4  A 773 (-4.6A)
None
None
 1.02A 2ab2B-1z26A:
undetectable		 2ab2B-1z26A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 LEU A 474
PHE A 766
VAL A 540
GLY A 539
LEU A 415
 None
 1.27A 2bxeB-1z26A:
undetectable		 2bxeB-1z26A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.23A 2drcA-1z26A:
undetectable		 2drcA-1z26A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 8 TYR A 272
LEU A 277
ALA A 282
HIS A 173
 None
 0.98A 2wekA-1z26A:
2.2		 2wekA-1z26A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ASP A 599
VAL A 559
ILE A 590
GLN A 593
PRO A 561
 None
 1.29A 2yzqA-1z26A:
undetectable		 2yzqA-1z26A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 LEU A 277
ILE A 125
ARG A 111
TYR A 122
 None
 1.41A 2zlcA-1z26A:
undetectable		 2zlcA-1z26A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 ASP A 313
ASP A 310
ASP A 138
 None
 0.72A 3douA-1z26A:
2.3		 3douA-1z26A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		6 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
ILE A 312
 None
 1.23A 3drcA-1z26A:
undetectable		 3drcA-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 10 ILE A 344
ILE A 332
GLY A 580
TYR A 743
PRO A 740
 None
 0.93A 3elzB-1z26A:
0.9		 3elzB-1z26A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 10 ILE A 344
ILE A 332
GLY A 580
TYR A 743
PRO A 740
 None
 0.90A 3elzC-1z26A:
undetectable		 3elzC-1z26A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 6 LEU A 392
GLU A 507
ASN A 481
PHE A 399
 None
 1.28A 3i9jB-1z26A:
3.6		 3i9jB-1z26A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ALA A 400
LEU A 392
LEU A 483
VAL A 504
THR A 401
 None
 1.16A 3ix9A-1z26A:
undetectable		 3ix9A-1z26A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 LEU A 510
LEU A 392
LEU A 483
VAL A 504
THR A 401
 None
 1.17A 3ix9A-1z26A:
undetectable		 3ix9A-1z26A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 VAL A 459
VAL A 500
SER A 502
 None
 0.72A 3n8xB-1z26A:
undetectable		 3n8xB-1z26A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 ILE A 557
ARG A 700
THR A 652
GLU A 636
 None
 1.39A 3ny4A-1z26A:
undetectable		 3ny4A-1z26A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
 None
 1.17A 3ql0A-1z26A:
undetectable		 3ql0A-1z26A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
ILE A 312
 None
 1.12A 3ql3A-1z26A:
undetectable		 3ql3A-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 6 ILE A 623
LEU A 625
PHE A 604
GLY A 638
 None
 1.00A 3sj1X-1z26A:
undetectable		 3sj1X-1z26A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 4 LEU A 177
ILE A 182
TYR A 190
TYR A 122
 None
 1.34A 3vt7A-1z26A:
undetectable		 3vt7A-1z26A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
 None
 1.12A 4ej1B-1z26A:
undetectable		 4ej1B-1z26A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 10 ILE A 554
ALA A 739
SER A 572
PRO A 587
ILE A 555
 None
 1.07A 4g8zX-1z26A:
undetectable		 4g8zX-1z26A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.81A 4n48A-1z26A:
undetectable		 4n48A-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.75A 4n48B-1z26A:
undetectable		 4n48B-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 4 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.82A 4n49A-1z26A:
undetectable		 4n49A-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 LEU A 474
PHE A 766
VAL A 540
GLY A 539
LEU A 415
 None
 1.26A 4ot2A-1z26A:
undetectable		 4ot2A-1z26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 LEU A  91
LEU A 141
ASN A  99
 None
 0.71A 4otwA-1z26A:
undetectable		 4otwA-1z26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 LEU A 737
LEU A 767
ASN A 749
 None
 0.75A 4otwA-1z26A:
undetectable		 4otwA-1z26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 GLY A 674
ASP A  86
ASN A  85
ALA A 676
TYR A 678
 None
 1.17A 4pclA-1z26A:
undetectable		 4pclA-1z26A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 ILE A 311
LEU A  93
LYS A  97
ILE A 143
LEU A 106
 None
 1.13A 4qlgA-1z26A:
undetectable		 4qlgA-1z26A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 LYS A 621
ILE A 623
ILE A 555
 None
 0.63A 4y0qA-1z26A:
undetectable		 4y0qA-1z26A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 TYR A 678
ILE A 319
PRO A 681
THR A 690
 None
 1.26A 4ze1A-1z26A:
undetectable		 4ze1A-1z26A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 GLY A 539
TYR A 543
TYR A 728
GLY A 729
 None
 1.01A 5ayfA-1z26A:
undetectable		 5ayfA-1z26A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 TYR A 768
LYS A 756
LYS A 758
 None
 1.33A 5dbyA-1z26A:
0.0		 5dbyA-1z26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 8 VAL A 661
VAL A  92
ILE A 101
ILE A  16
ILE A 312
 None
 1.30A 5hi2A-1z26A:
undetectable		 5hi2A-1z26A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 7 ILE A 145
VAL A 128
ARG A 111
GLN A 148
 WO4  A 773 (-3.8A)
None
None
None
 1.21A 5kkzC-1z26A:
undetectable
5kkzE-1z26A:
undetectable		 5kkzC-1z26A:
12.26
5kkzE-1z26A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 7 ILE A 145
VAL A 128
ARG A 111
GLN A 148
 WO4  A 773 (-3.8A)
None
None
None
 1.19A 5kkzK-1z26A:
undetectable
5kkzQ-1z26A:
undetectable		 5kkzK-1z26A:
18.89
5kkzQ-1z26A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 7 ILE A 145
VAL A 128
ARG A 111
GLN A 148
 WO4  A 773 (-3.8A)
None
None
None
 1.23A 5kkzM-1z26A:
undetectable
5kkzO-1z26A:
undetectable		 5kkzM-1z26A:
12.26
5kkzO-1z26A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 GLU A 287
TYR A 288
ARG A 114
 None
 0.82A 5uunA-1z26A:
undetectable		 5uunA-1z26A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 GLU A 287
TYR A 288
ARG A 114
 None
 0.75A 5uunB-1z26A:
undetectable		 5uunB-1z26A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 PHE A 611
ILE A 555
PHE A 747
ALA A 748
ILE A 569
 None
 1.05A 5vceA-1z26A:
undetectable		 5vceA-1z26A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 8 VAL A 159
ASP A 162
PRO A 243
LEU A 203
 None
 0.83A 5w3jB-1z26A:
undetectable		 5w3jB-1z26A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		5 / 12 LEU A 737
VAL A 655
GLY A 629
PHE A 603
VAL A 574
 None
 0.94A 6a94B-1z26A:
undetectable		 6a94B-1z26A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 7 ALA A 750
PHE A 611
LEU A 762
ILE A 557
 None
 0.82A 6b5vA-1z26A:
undetectable
6b5vB-1z26A:
undetectable		 6b5vA-1z26A:
8.05
6b5vB-1z26A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 LEU A 530
GLN A 503
LYS A 513
 None
 0.77A 6exiB-1z26A:
2.1		 6exiB-1z26A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		3 / 3 LEU A 530
GLN A 503
LYS A 513
 None
 0.75A 6exiA-1z26A:
2.1		 6exiA-1z26A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 6 VAL A 534
LEU A 538
LEU A 415
MET A 384
 None
 0.99A 6f6sA-1z26A:
0.2
6f6sB-1z26A:
undetectable		 6f6sA-1z26A:
7.48
6f6sB-1z26A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 7 TYR A 272
HIS A 173
LEU A 155
TYR A 122
 None
 1.40A 6g2pA-1z26A:
undetectable		 6g2pA-1z26A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1z26 ARGONAUTE
(Pyrococcus
furiosus) 		4 / 5 VAL A 526
PHE A 385
MET A 384
GLY A 473
 None
 1.35A 6hd4A-1z26A:
undetectable		 6hd4A-1z26A:
9.18