SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 GLU A 160
GLU A 167
LEU A  60
 None
 0.60A 1v8bA-1z2aA:
2.3		 1v8bA-1z2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 GLU A 160
GLU A 167
LEU A  60
 None
 0.68A 1v8bB-1z2aA:
2.3		 1v8bB-1z2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 PHE A 162
ARG A 149
ASN A 157
 None
 0.85A 1xzxX-1z2aA:
undetectable		 1xzxX-1z2aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 TRP A 103
THR A  65
TYR A  78
 None
 1.04A 2a3aA-1z2aA:
undetectable		 2a3aA-1z2aA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 TRP A 103
THR A  65
TYR A  78
 None
 1.08A 2a3aB-1z2aA:
2.8		 2a3aB-1z2aA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 TRP A 103
THR A  65
TYR A  78
 None
 1.07A 2a3bA-1z2aA:
undetectable		 2a3bA-1z2aA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		4 / 6 ARG A  28
SER A 151
PHE A  34
GLU A 154
 None
GDP  A 201 (-3.6A)
GDP  A 201 (-4.4A)
None
 1.45A 2c8aC-1z2aA:
undetectable		 2c8aC-1z2aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		3 / 3 GLY A  81
TRP A  63
VAL A  13
 None
 0.77A 3n62B-1z2aA:
undetectable		 3n62B-1z2aA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		4 / 7 VAL A  53
LEU A  60
MET A  12
ILE A  10
 None
 1.03A 3rfmA-1z2aA:
undetectable		 3rfmA-1z2aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		4 / 7 ILE A  51
LEU A  60
MET A  12
LEU A  62
 None
 1.00A 5u4sA-1z2aA:
5.6		 5u4sA-1z2aA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		5 / 12 ALA A  99
LEU A 118
TYR A  78
VAL A  20
THR A  91
 None
None
None
GDP  A 201 (-4.0A)
None
 1.40A 5vlmD-1z2aA:
undetectable		 5vlmD-1z2aA:
25.89