SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		3 / 3 TRP A 180
ALA A 174
VAL A 172
 None
 0.96A 1av2C-1z2iA:
undetectable
1av2D-1z2iA:
undetectable		 1av2C-1z2iA:
4.05
1av2D-1z2iA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		3 / 3 ALA A 174
VAL A 172
TRP A 180
 None
 1.00A 2izqA-1z2iA:
undetectable
2izqB-1z2iA:
undetectable		 2izqA-1z2iA:
4.05
2izqB-1z2iA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		4 / 5 SER A 210
GLY A 214
HIS A 163
ASP A 157
 None
 1.04A 2oxtB-1z2iA:
undetectable		 2oxtB-1z2iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 12 ALA A 102
PHE A 277
ILE A 115
LEU A 281
THR A  99
 None
 1.15A 2w3bB-1z2iA:
undetectable		 2w3bB-1z2iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		3 / 3 TRP A 180
ALA A 174
VAL A 172
 None
 0.99A 3l8lA-1z2iA:
undetectable
3l8lB-1z2iA:
undetectable		 3l8lA-1z2iA:
4.05
3l8lB-1z2iA:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 11 VAL A 170
ALA A 169
GLY A 130
ALA A 276
PHE A 146
 None
 1.25A 3qxyB-1z2iA:
0.7
3qxyQ-1z2iA:
undetectable		 3qxyB-1z2iA:
24.26
3qxyQ-1z2iA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 12 VAL A  62
ILE A 120
GLY A 273
ALA A  93
ALA A  90
 None
 1.00A 3sufD-1z2iA:
undetectable		 3sufD-1z2iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 12 PHE A 350
TYR A 357
VAL A 335
ALA A 342
SER A 344
 None
 1.38A 4a84A-1z2iA:
undetectable		 4a84A-1z2iA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 11 THR A  87
ALA A 119
LEU A 251
PHE A 277
SER A  80
 None
 1.20A 4claA-1z2iA:
undetectable		 4claA-1z2iA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		4 / 7 VAL A 223
ALA A 209
VAL A 194
ARG A 198
 None
 0.86A 5fpdB-1z2iA:
undetectable		 5fpdB-1z2iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 12 ASN A 148
HIS A 125
PHE A 126
ALA A 276
PHE A 268
 None
NAD  A 700 (-3.6A)
NAD  A 700 (-4.5A)
None
None
 1.24A 5igyA-1z2iA:
undetectable		 5igyA-1z2iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		3 / 3 SER A 248
ALA A 276
THR A  99
 None
 0.71A 5n0xB-1z2iA:
undetectable		 5n0xB-1z2iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		4 / 4 GLY A 116
LEU A 109
VAL A 118
GLU A  86
 None
 1.34A 5yw0A-1z2iA:
0.0		 5yw0A-1z2iA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1z2i MALATE DEHYDROGENASE
(Agrobacterium
tumefaciens) 		5 / 7 PHE A 343
LEU A  58
GLY A  54
LEU A  14
GLY A 332
 None
 1.49A 6eu9D-1z2iA:
undetectable		 6eu9D-1z2iA:
13.52