SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ASN X 235
ILE X 229
ASN X 175
THR X 193
 None
 0.97A 1h7xA-1z2oX:
undetectable		 1h7xA-1z2oX:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ASN X 235
ILE X 229
ASN X 175
THR X 193
 None
 0.95A 1h7xB-1z2oX:
undetectable		 1h7xB-1z2oX:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ASN X 235
ILE X 229
ASN X 175
THR X 193
 None
 0.95A 1h7xC-1z2oX:
undetectable		 1h7xC-1z2oX:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ASN X 235
ILE X 229
ASN X 175
THR X 193
 None
 0.96A 1h7xD-1z2oX:
undetectable		 1h7xD-1z2oX:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 5 MET X  65
HIS X  60
ILE X  97
HIS X 147
 None
None
None
ADP  X 871 ( 3.6A)
 1.21A 1osvB-1z2oX:
0.0		 1osvB-1z2oX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		3 / 3 LEU X 187
ASN X 185
ARG X 257
 None
 0.94A 2qhfA-1z2oX:
undetectable		 2qhfA-1z2oX:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 5 PHE X 208
SER X 194
PHE X 144
ILE X 177
 None
ADP  X 871 (-2.6A)
None
ADP  X 871 (-4.6A)
 1.39A 2v0mD-1z2oX:
undetectable		 2v0mD-1z2oX:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		5 / 12 VAL X 269
PHE X 305
PHE X  22
LEU X  13
TYR X 296
 None
 1.49A 3apxA-1z2oX:
undetectable		 3apxA-1z2oX:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 HIS X  88
LEU X  13
TYR X 296
ILE X 183
 None
 0.98A 3avpA-1z2oX:
undetectable		 3avpA-1z2oX:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 GLN X  18
GLU X  68
PHE X  10
PRO X  47
 None
 1.30A 3ql6A-1z2oX:
undetectable		 3ql6A-1z2oX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 VAL X 287
LEU X 267
MET X  91
ILE X  97
 None
 0.96A 3rfmA-1z2oX:
undetectable		 3rfmA-1z2oX:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 PHE X  22
PRO X 294
TYR X 296
PHE X 293
 None
I4P  X2699 (-4.6A)
None
None
 1.24A 4grqA-1z2oX:
undetectable
4grqC-1z2oX:
undetectable		 4grqA-1z2oX:
17.45
4grqC-1z2oX:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.03A 4w5oA-1z2oX:
undetectable		 4w5oA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.03A 4w5qA-1z2oX:
3.6		 4w5qA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.08A 4z4cA-1z2oX:
3.5		 4z4cA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.01A 4z4dA-1z2oX:
3.3		 4z4dA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.04A 4z4eA-1z2oX:
undetectable		 4z4eA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 7 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.04A 4z4gA-1z2oX:
3.6		 4z4gA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		5 / 10 ILE X 224
ILE X 216
VAL X 223
ASP X 207
ILE X 151
 None
 1.32A 5lg3F-1z2oX:
undetectable		 5lg3F-1z2oX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 LEU X 247
ILE X 177
THR X 191
MET X 256
 None
ADP  X 871 (-4.6A)
None
None
 1.36A 5ljeA-1z2oX:
undetectable		 5ljeA-1z2oX:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		5 / 12 LEU X 124
VAL X 114
PHE X 163
ILE X 161
GLU X 118
 None
 1.42A 5w8aA-1z2oX:
undetectable		 5w8aA-1z2oX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 6 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.14A 6cbdA-1z2oX:
3.5		 6cbdA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		5 / 9 ILE X 106
ILE X 102
GLU X 255
VAL X 287
ILE X 108
 None
 1.36A 6hloA-1z2oX:
2.7		 6hloA-1z2oX:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE
(Entamoeba
histolytica) 		4 / 8 VAL X 263
GLN X 168
ASN X  98
ILE X  97
 None
ADP  X 871 (-3.8A)
None
None
 0.98A 6hzpA-1z2oX:
undetectable		 6hzpA-1z2oX:
21.30