SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 8 ALA A 295
LEU A 329
LEU A 330
ALA A 335
 None
 0.81A 1e7cA-1z2zA:
undetectable		 1e7cA-1z2zA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 5 HIS A 239
GLU A 240
ALA A 198
SER A 257
 None
 1.32A 1errA-1z2zA:
0.0
1errB-1z2zA:
undetectable		 1errA-1z2zA:
21.48
1errB-1z2zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 7 THR A  19
THR A 156
VAL A 139
MET A 437
 None
 1.17A 1tv8B-1z2zA:
undetectable		 1tv8B-1z2zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 5 PRO A 340
GLY A 359
ASN A 358
GLY A 354
 None
 0.96A 1zlqA-1z2zA:
undetectable		 1zlqA-1z2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		3 / 3 ARG A 259
VAL A 270
GLY A 370
 None
 0.58A 2avvE-1z2zA:
undetectable		 2avvE-1z2zA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 6 ALA A 422
PHE A 414
VAL A  35
PHE A  33
 None
 0.71A 2cizA-1z2zA:
undetectable		 2cizA-1z2zA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 6 VAL A 178
SER A 177
LEU A 237
HIS A 239
 None
 1.35A 2f8dA-1z2zA:
undetectable		 2f8dA-1z2zA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 7 THR A  19
THR A 156
VAL A 139
MET A 437
 None
 1.12A 2fb2B-1z2zA:
undetectable		 2fb2B-1z2zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		5 / 12 GLY A 119
GLY A  44
GLU A  45
ALA A 102
GLU A  42
 None
 1.17A 2vdvE-1z2zA:
undetectable		 2vdvE-1z2zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		5 / 11 GLY A 119
GLY A  44
GLU A  45
ALA A 102
GLU A  42
 None
 1.18A 2vdvF-1z2zA:
undetectable		 2vdvF-1z2zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		3 / 3 PHE A 170
ASN A 279
PHE A 175
 None
 0.92A 2zbuD-1z2zA:
undetectable		 2zbuD-1z2zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 8 PHE A 269
GLY A 186
GLU A 191
PHE A 376
 None
 0.79A 3aodA-1z2zA:
2.1		 3aodA-1z2zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 7 ILE A 281
TYR A 278
ILE A 277
GLN A 274
 None
 1.00A 3hgxA-1z2zA:
undetectable		 3hgxA-1z2zA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		3 / 3 THR A 315
ASP A 311
GLU A 306
 None
 0.83A 3qowA-1z2zA:
undetectable		 3qowA-1z2zA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		3 / 3 PRO A 205
VAL A 181
HIS A 183
 None
 0.83A 4pevC-1z2zA:
undetectable		 4pevC-1z2zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 6 GLY A 383
THR A 384
SER A 381
HIS A 271
 None
 0.71A 5ewuA-1z2zA:
undetectable		 5ewuA-1z2zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 6 GLY A 383
THR A 384
SER A 381
HIS A 271
 None
 0.95A 5ewuB-1z2zA:
undetectable		 5ewuB-1z2zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		4 / 8 ILE A 277
THR A 346
PRO A 340
PHE A 348
 None
 1.08A 5x23A-1z2zA:
undetectable		 5x23A-1z2zA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D
(Methanosarcina
mazei) 		3 / 3 LYS A  77
SER A  96
SER A 124
 None
 1.04A 6gbfA-1z2zA:
undetectable		 6gbfA-1z2zA:
22.09