SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		4 / 7 GLY A 116
PHE A 115
PRO A  97
ASP A 119
 None
 1.18A 2aouB-1z3aA:
undetectable		 2aouB-1z3aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		5 / 9 ILE A 110
GLY A 103
HIS A 139
ARG A 109
ILE A 106
 None
 1.32A 2y7wA-1z3aA:
undetectable		 2y7wA-1z3aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		5 / 10 VAL A  41
VAL A  93
LEU A  91
GLY A  42
GLY A  55
 None
 1.25A 3ls4H-1z3aA:
undetectable		 3ls4H-1z3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		5 / 10 ILE A 106
ALA A 124
ILE A 143
VAL A 113
VAL A 141
 None
 1.02A 3me6A-1z3aA:
undetectable		 3me6A-1z3aA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		4 / 5 LEU A 155
GLU A 151
LEU A  27
LYS A  31
 None
 1.25A 4k4yA-1z3aA:
undetectable		 4k4yA-1z3aA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		4 / 5 LEU A 155
GLU A 151
LEU A  27
LYS A  31
 None
 1.26A 4k4yI-1z3aA:
undetectable		 4k4yI-1z3aA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Escherichia
coli) 		3 / 3 VAL A 141
GLU A 142
ILE A 110
 None
 0.65A 6f7lB-1z3aA:
undetectable		 6f7lB-1z3aA:
18.75