SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MMT_A_H4BA1426_1 (PHENYLALANINE-4-HYDR OXYLASE)	1z3d	UBIQUITIN-CONJUGATIN G ENZYME E2 1 (Caenorhabditis elegans)	5 / 11	VAL A 24 LEU A 16 LEU A 9 THR A 107 TYR A 63	None	1.38A	1mmtA-1z3dA: undetectable	1mmtA-1z3dA: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_A_LNLA701_2 (PROSTAGLANDIN G/H SYNTHASE 2)	1z3d	UBIQUITIN-CONJUGATIN G ENZYME E2 1 (Caenorhabditis elegans)	4 / 5	VAL A 70 LEU A 55 SER A 56 MET A 76	None	1.27A	4e1gA-1z3dA: undetectable	4e1gA-1z3dA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GTR_A_ESTA601_2 (ESTROGEN RECEPTOR)	1z3d	UBIQUITIN-CONJUGATIN G ENZYME E2 1 (Caenorhabditis elegans)	4 / 5	LEU A 55 LEU A 92 PHE A 72 LEU A 112	None	0.93A	5gtrA-1z3dA: undetectable	5gtrA-1z3dA: 19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_A_QPSA602_1 (-)	1z3d	UBIQUITIN-CONJUGATIN G ENZYME E2 1 (Caenorhabditis elegans)	5 / 12	VAL A 141 ASP A 90 GLN A 110 PRO A 43 GLY A 51	None	1.45A	6gnfA-1z3dA: undetectable	6gnfA-1z3dA: 14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_C_QPSC602_2 (-)	1z3d	UBIQUITIN-CONJUGATIN G ENZYME E2 1 (Caenorhabditis elegans)	5 / 12	VAL A 141 ASP A 90 GLN A 110 PRO A 43 GLY A 51	None	1.45A	6gnfC-1z3dA: undetectable	6gnfC-1z3dA: 14.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MMT_A_H4BA1426_1","PHENYLALANINE-4-HYDROXYLASE","1z3d","UBIQUITIN-CONJUGATING ENZYME E2 1","Caenorhabditis elegans",5,"VAL A  24;LEU A  16;LEU A   9;THR A 107;TYR A  63","None","1.38A","1mmtA-1z3dA:undetectable","1mmtA-1z3dA:18.35"],["4E1G_A_LNLA701_2","PROSTAGLANDIN G\/H SYNTHASE 2","1z3d","UBIQUITIN-CONJUGATING ENZYME E2 1","Caenorhabditis elegans",4,"VAL A  70;LEU A  55;SER A  56;MET A  76","None","1.27A","4e1gA-1z3dA:undetectable","4e1gA-1z3dA:15.50"],["5GTR_A_ESTA601_2","ESTROGEN RECEPTOR","1z3d","UBIQUITIN-CONJUGATING ENZYME E2 1","Caenorhabditis elegans",4,"LEU A  55;LEU A  92;PHE A  72;LEU A 112","None","0.93A","5gtrA-1z3dA:undetectable","5gtrA-1z3dA:19.92"],["6GNF_A_QPSA602_1","-","1z3d","UBIQUITIN-CONJUGATING ENZYME E2 1","Caenorhabditis elegans",5,"VAL A 141;ASP A  90;GLN A 110;PRO A  43;GLY A  51","None","1.45A","6gnfA-1z3dA:undetectable","6gnfA-1z3dA:14.77"],["6GNF_C_QPSC602_2","-","1z3d","UBIQUITIN-CONJUGATING ENZYME E2 1","Caenorhabditis elegans",5,"VAL A 141;ASP A  90;GLN A 110;PRO A  43;GLY A  51","None","1.45A","6gnfC-1z3dA:undetectable","6gnfC-1z3dA:14.77"]]