SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 PHE X 561
TYR X 532
ILE X 562
VAL X 510
 None
 0.71A 1fslA-1z3iX:
undetectable		 1fslA-1z3iX:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 PHE X 561
TYR X 532
ILE X 562
VAL X 510
 None
 0.70A 1fslB-1z3iX:
undetectable		 1fslB-1z3iX:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 6 ASP X 246
LEU X 249
VAL X 250
ILE X 253
 None
 0.46A 1s9qA-1z3iX:
undetectable		 1s9qA-1z3iX:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 ARG X 603
ARG X 600
ILE X 612
 SO4  X 902 ( 2.9A)
SO4  X 902 (-2.8A)
None
 0.64A 1uobA-1z3iX:
undetectable		 1uobA-1z3iX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 10 PHE X 272
THR X 271
ALA X 305
ALA X 276
GLU X 277
 None
 1.32A 1wygA-1z3iX:
2.7		 1wygA-1z3iX:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 LEU X 526
PHE X 523
LEU X 499
GLN X 414
VAL X 713
 None
 1.36A 2qd4A-1z3iX:
undetectable		 2qd4A-1z3iX:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 7 LEU X 520
LEU X 615
TYR X 534
MET X 492
 None
 1.22A 2w8yA-1z3iX:
undetectable		 2w8yA-1z3iX:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 SER X 144
GLU X 108
ASP X 140
 None
 0.85A 3bwmA-1z3iX:
2.3		 3bwmA-1z3iX:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 SER X 144
GLU X 108
ASP X 140
 None
 0.85A 3bwyA-1z3iX:
3.7		 3bwyA-1z3iX:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 ASN X 452
HIS X 453
VAL X 484
 None
 0.60A 3elzB-1z3iX:
undetectable		 3elzB-1z3iX:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 6 LEU X 341
SER X 338
ILE X 381
CYH X 385
 None
 0.98A 3ko0B-1z3iX:
undetectable		 3ko0B-1z3iX:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 VAL X 725
VAL X 494
SER X 717
 None
 0.68A 3n8xB-1z3iX:
undetectable		 3n8xB-1z3iX:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 SER X 214
ASP X 238
GLU X 270
THR X 540
 SO4  X 737 (-4.3A)
None
SO4  X 737 (-4.1A)
None
 0.87A 4lnwA-1z3iX:
undetectable		 4lnwA-1z3iX:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 TYR X 611
ILE X 402
GLN X 404
VAL X 725
 None
 0.89A 4ma7A-1z3iX:
undetectable		 4ma7A-1z3iX:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		3 / 3 LEU X 274
LEU X 306
ASN X 300
 None
 0.72A 4otwA-1z3iX:
undetectable		 4otwA-1z3iX:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 ILE X 498
THR X 502
LEU X 495
LEU X 512
PHE X 561
 None
 1.33A 4pbhA-1z3iX:
undetectable		 4pbhA-1z3iX:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 ILE X 387
THR X 163
ARG X 166
LEU X 194
LEU X 190
 None
 1.19A 4qynB-1z3iX:
undetectable		 4qynB-1z3iX:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 11 SER X 446
LEU X 417
PHE X 468
ASP X 469
GLN X 424
 None
 1.25A 4uuuB-1z3iX:
undetectable		 4uuuB-1z3iX:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 LEU X 181
ILE X 393
LEU X 398
ALA X 599
 None
 0.77A 4wboB-1z3iX:
undetectable		 4wboB-1z3iX:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 PRO X 354
GLY X 358
GLY X 371
LEU X 375
ALA X 361
 None
 0.93A 5c0oF-1z3iX:
3.4		 5c0oF-1z3iX:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 ILE X 317
ASP X 290
GLY X 182
THR X 184
 None
None
SO4  X 901 ( 3.3A)
SO4  X 902 (-3.9A)
 1.06A 5hwaA-1z3iX:
undetectable		 5hwaA-1z3iX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 11 ASN X 452
VAL X 513
SER X 514
THR X 519
LEU X 582
 None
 1.46A 5jh7B-1z3iX:
undetectable		 5jh7B-1z3iX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 ARG X 388
GLY X 319
TYR X 329
ARG X 389
LEU X 386
 SO4  X 736 (-4.0A)
None
None
None
None
 1.46A 5lsuA-1z3iX:
undetectable		 5lsuA-1z3iX:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		5 / 12 ILE X 562
VAL X 583
PRO X 486
GLU X 485
TYR X 532
 None
 1.39A 5mqtC-1z3iX:
undetectable		 5mqtC-1z3iX:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 THR X 618
THR X 669
ARG X 672
GLN X 627
 None
 1.41A 5tzoA-1z3iX:
undetectable		 5tzoA-1z3iX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 8 THR X 618
THR X 669
ARG X 672
GLN X 627
 None
 1.41A 5tzoC-1z3iX:
undetectable		 5tzoC-1z3iX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 6 GLU X 352
HIS X 334
ALA X 344
GLN X 345
 None
 1.45A 6f6jC-1z3iX:
undetectable
6f6jD-1z3iX:
undetectable		 6f6jC-1z3iX:
20.18
6f6jD-1z3iX:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 7 ARG X 536
TYR X 534
GLU X 524
ASP X 521
 None
 1.26A 6mn5B-1z3iX:
undetectable		 6mn5B-1z3iX:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1z3i SIMILAR TO
RAD54-LIKE
(Danio
rerio) 		4 / 7 ASP X 538
ARG X 536
GLU X 524
ASP X 521
 None
 1.33A 6mn5B-1z3iX:
undetectable		 6mn5B-1z3iX:
8.40