SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfA-1z3zA:
undetectable		 1gsfA-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfB-1z3zA:
undetectable		 1gsfB-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfC-1z3zA:
undetectable		 1gsfC-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 PHE A 256
ARG A 251
LEU A 411
VAL A 317
 None
 0.91A 1gsfC-1z3zA:
undetectable		 1gsfC-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfD-1z3zA:
undetectable		 1gsfD-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 8 ALA A 428
GLY A 379
ILE A 395
ILE A 351
ILE A 429
 None
 1.35A 1hshD-1z3zA:
undetectable		 1hshD-1z3zA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 ALA A 146
ALA A 148
LEU A 221
GLY A 140
LEU A 213
 None
None
None
PLP  A 434 ( 3.9A)
None
 1.25A 1qabF-1z3zA:
undetectable		 1qabF-1z3zA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 9 LEU A 433
ILE A 365
GLY A 426
CYH A 386
PHE A 405
 None
 1.34A 1td7A-1z3zA:
undetectable		 1td7A-1z3zA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 LEU A 108
LEU A  90
ALA A 311
SER A  84
THR A 302
 None
 1.44A 2aa5B-1z3zA:
undetectable		 2aa5B-1z3zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 LEU A 425
ILE A 351
ILE A 382
ILE A 365
 None
 0.75A 2bu8A-1z3zA:
undetectable		 2bu8A-1z3zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 7 ARG A 176
GLU A 188
PRO A 168
ALA A 135
 None
 1.48A 2ejgB-1z3zA:
1.3		 2ejgB-1z3zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		3 / 3 ALA A 245
GLY A 140
SER A 215
 PLP  A 434 (-3.6A)
PLP  A 434 ( 3.9A)
MES  A 435 (-3.2A)
 0.56A 2ivuA-1z3zA:
undetectable		 2ivuA-1z3zA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 ASP A 353
LEU A 361
GLY A 362
ARG A 338
 None
 1.39A 2j2pD-1z3zA:
0.0
2j2pE-1z3zA:
0.0		 2j2pD-1z3zA:
18.79
2j2pE-1z3zA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 LEU A 359
PRO A 409
LEU A 337
ARG A 338
 None
 1.49A 2qd2A-1z3zA:
2.6		 2qd2A-1z3zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 10 MET A 401
GLY A 400
ARG A 176
ALA A 169
LEU A 398
 None
 1.38A 2vd0B-1z3zA:
0.0		 2vd0B-1z3zA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 THR A 371
ARG A 174
ASP A 349
GLU A 364
 None
 0.83A 2zw9A-1z3zA:
3.9		 2zw9A-1z3zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 GLY A  58
LEU A  57
PRO A 279
ALA A  55
VAL A  56
 None
 1.07A 3av6A-1z3zA:
undetectable		 3av6A-1z3zA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 7 LEU A 240
ARG A 231
PRO A 170
GLY A 224
 None
 1.05A 3hcnA-1z3zA:
undetectable		 3hcnA-1z3zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 PHE A 207
TYR A 150
ILE A 283
LEU A 268
 None
 1.22A 3sudA-1z3zA:
0.0		 3sudA-1z3zA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 5 PHE A 207
TYR A 150
ILE A 283
LEU A 268
 None
 1.22A 3sueC-1z3zA:
undetectable		 3sueC-1z3zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		3 / 3 SER A 392
ASP A  39
ASP A   5
 None
 0.90A 3uj7A-1z3zA:
undetectable		 3uj7A-1z3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 PRO A  86
SER A  84
VAL A 317
GLY A 314
 None
 1.02A 4klrB-1z3zA:
2.6		 4klrB-1z3zA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 8 ALA A 148
ASP A 266
ILE A 241
ILE A 283
 None
 0.85A 4kttB-1z3zA:
undetectable		 4kttB-1z3zA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.38A 4qvlV-1z3zA:
undetectable
4qvlb-1z3zA:
undetectable		 4qvlV-1z3zA:
21.11
4qvlb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.38A 4qvlH-1z3zA:
undetectable
4qvlN-1z3zA:
undetectable		 4qvlH-1z3zA:
21.11
4qvlN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qvmV-1z3zA:
undetectable
4qvmb-1z3zA:
undetectable		 4qvmV-1z3zA:
21.11
4qvmb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qvmH-1z3zA:
undetectable
4qvmN-1z3zA:
undetectable		 4qvmH-1z3zA:
21.11
4qvmN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 4qvpV-1z3zA:
undetectable
4qvpb-1z3zA:
undetectable		 4qvpV-1z3zA:
21.11
4qvpb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 4qvpH-1z3zA:
undetectable
4qvpN-1z3zA:
undetectable		 4qvpH-1z3zA:
21.11
4qvpN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.37A 4qvqV-1z3zA:
undetectable
4qvqb-1z3zA:
undetectable		 4qvqV-1z3zA:
21.11
4qvqb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.38A 4qvqH-1z3zA:
undetectable
4qvqN-1z3zA:
undetectable		 4qvqH-1z3zA:
21.11
4qvqN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.41A 4qvwV-1z3zA:
undetectable
4qvwb-1z3zA:
undetectable		 4qvwV-1z3zA:
21.11
4qvwb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qvwH-1z3zA:
undetectable
4qvwN-1z3zA:
undetectable		 4qvwH-1z3zA:
21.11
4qvwN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qw0V-1z3zA:
undetectable
4qw0b-1z3zA:
undetectable		 4qw0V-1z3zA:
21.11
4qw0b-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 4qw0H-1z3zA:
undetectable
4qw0N-1z3zA:
undetectable		 4qw0H-1z3zA:
21.11
4qw0N-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.38A 4qw1V-1z3zA:
undetectable
4qw1b-1z3zA:
undetectable		 4qw1V-1z3zA:
21.11
4qw1b-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.38A 4qw1H-1z3zA:
undetectable
4qw1N-1z3zA:
undetectable		 4qw1H-1z3zA:
21.11
4qw1N-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qw3V-1z3zA:
undetectable
4qw3b-1z3zA:
undetectable		 4qw3V-1z3zA:
21.11
4qw3b-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.40A 4qw3H-1z3zA:
undetectable
4qw3N-1z3zA:
undetectable		 4qw3H-1z3zA:
21.11
4qw3N-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 ASN A 394
VAL A 404
THR A 383
ILE A 382
 None
 1.23A 4retA-1z3zA:
undetectable		 4retA-1z3zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 ASN A 394
VAL A 404
THR A 383
ILE A 382
 None
 1.23A 4retC-1z3zA:
undetectable		 4retC-1z3zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 5 LEU A 106
TYR A 298
ALA A 118
ILE A 267
 None
 1.00A 4y03B-1z3zA:
undetectable		 4y03B-1z3zA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		3 / 3 SER A  84
GLU A  70
GLU A  63
 None
 0.74A 4ymgB-1z3zA:
undetectable		 4ymgB-1z3zA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.34A 5bxnV-1z3zA:
undetectable
5bxnb-1z3zA:
undetectable		 5bxnV-1z3zA:
21.11
5bxnb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.35A 5bxnH-1z3zA:
undetectable
5bxnN-1z3zA:
undetectable		 5bxnH-1z3zA:
21.11
5bxnN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 GLY A 275
GLY A 277
GLY A  58
LEU A  57
LEU A 274
 None
 1.00A 5c0oG-1z3zA:
2.2		 5c0oG-1z3zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 5cz7H-1z3zA:
undetectable
5cz7N-1z3zA:
undetectable		 5cz7H-1z3zA:
21.11
5cz7N-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 5d0xV-1z3zA:
undetectable
5d0xb-1z3zA:
undetectable		 5d0xV-1z3zA:
21.11
5d0xb-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.39A 5d0xH-1z3zA:
undetectable
5d0xN-1z3zA:
undetectable		 5d0xH-1z3zA:
21.11
5d0xN-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 PRO A 170
HIS A 139
GLY A 133
PHE A 134
LEU A 221
 None
 1.28A 5eeiA-1z3zA:
2.7		 5eeiA-1z3zA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 PRO A 170
HIS A 139
GLY A 133
PHE A 134
LEU A 221
 None
 1.27A 5eeiB-1z3zA:
undetectable		 5eeiB-1z3zA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		6 / 12 LEU A 107
ALA A  91
THR A  92
LEU A  94
GLY A 314
LEU A 315
 None
 1.34A 5h2uA-1z3zA:
undetectable		 5h2uA-1z3zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 ILE A 289
VAL A 284
ALA A 281
ALA A 282
THR A 302
 None
 1.36A 5igpA-1z3zA:
undetectable		 5igpA-1z3zA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.37A 5l66V-1z3zA:
undetectable
5l66b-1z3zA:
undetectable		 5l66V-1z3zA:
21.11
5l66b-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 11 HIS A 139
THR A 269
GLY A 248
ALA A 245
THR A 273
 None
None
None
PLP  A 434 (-3.6A)
None
 1.36A 5l66H-1z3zA:
undetectable
5l66N-1z3zA:
undetectable		 5l66H-1z3zA:
21.11
5l66N-1z3zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 GLU A 210
PRO A 211
ILE A 212
LEU A 213
 PLP  A 434 (-3.8A)
None
None
None
 1.08A 5m45A-1z3zA:
undetectable		 5m45A-1z3zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 GLU A 210
PRO A 211
ILE A 212
LEU A 213
 PLP  A 434 (-3.8A)
None
None
None
 0.98A 5m45D-1z3zA:
undetectable		 5m45D-1z3zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 GLU A 210
PRO A 211
ILE A 212
LEU A 213
 PLP  A 434 (-3.8A)
None
None
None
 1.06A 5m45G-1z3zA:
undetectable		 5m45G-1z3zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		4 / 4 GLU A 210
PRO A 211
ILE A 212
LEU A 213
 PLP  A 434 (-3.8A)
None
None
None
 1.00A 5m45J-1z3zA:
undetectable		 5m45J-1z3zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 10 LEU A 360
GLY A 358
GLY A 253
VAL A  56
ALA A 408
 None
 1.20A 5o96E-1z3zA:
undetectable
5o96F-1z3zA:
undetectable		 5o96E-1z3zA:
21.18
5o96F-1z3zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		3 / 3 THR A 252
THR A 254
ARG A 260
 None
 1.07A 5wm2A-1z3zA:
3.2		 5wm2A-1z3zA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1z3z DIALKYLGLYCINE
DECARBOXYLASE
(Burkholderia
cepacia) 		5 / 12 LEU A 342
LEU A 337
GLY A 334
ILE A 407
ALA A 408
 None
 1.35A 6qxsD-1z3zA:
undetectable		 6qxsD-1z3zA:
23.57