SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 ASN A 536
GLY A 424
TYR A 539
VAL A 637
None
0.83A 1dbbH-1z45A:
undetectable
1dbbL-1z45A:
undetectable
1dbbH-1z45A:
17.60
1dbbL-1z45A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 10 THR A 160
PRO A 159
GLY A 158
LEU A 318
ARG A 144
None
None
None
UPG  A 704 (-3.9A)
None
1.27A 1h4oA-1z45A:
undetectable
1h4oB-1z45A:
undetectable
1h4oA-1z45A:
13.03
1h4oB-1z45A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 8 THR A 160
PRO A 159
GLY A 158
LEU A 318
ARG A 144
None
None
None
UPG  A 704 (-3.9A)
None
1.27A 1h4oG-1z45A:
undetectable
1h4oG-1z45A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 11 ILE A 532
LEU A 448
PRO A 498
LEU A 441
ASN A 451
None
1.43A 1mrlA-1z45A:
0.0
1mrlB-1z45A:
0.0
1mrlA-1z45A:
15.50
1mrlB-1z45A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 ILE A 532
LEU A 448
PRO A 498
LEU A 441
ASN A 451
None
1.48A 1mrlB-1z45A:
0.0
1mrlC-1z45A:
0.0
1mrlB-1z45A:
15.50
1mrlC-1z45A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 ASP A 490
LEU A 488
TYR A 520
THR A 535
ILE A 427
None
1.29A 1xoqB-1z45A:
undetectable
1xoqB-1z45A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 THR A 160
PRO A 159
TYR A 139
LEU A 157
None
0.92A 1z2bB-1z45A:
7.2
1z2bB-1z45A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 ASP A 207
ILE A 473
VAL A  29
None
0.54A 2avvD-1z45A:
undetectable
2avvD-1z45A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 ASN A 457
GLU A 665
HIS A 458
ALA A 663
GAL  A 700 (-3.6A)
GAL  A 700 (-2.7A)
GAL  A 700 (-4.1A)
None
0.83A 2bnnA-1z45A:
undetectable
2bnnB-1z45A:
undetectable
2bnnA-1z45A:
15.33
2bnnB-1z45A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 LEU A 121
GLN A 123
PHE A  80
LEU A  76
None
0.89A 2eilP-1z45A:
undetectable
2eilW-1z45A:
undetectable
2eilP-1z45A:
16.74
2eilW-1z45A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 10 ILE A 518
ALA A 431
ASN A 533
VAL A 637
TYR A 696
None
1.48A 2gl0A-1z45A:
0.0
2gl0B-1z45A:
0.0
2gl0A-1z45A:
16.70
2gl0B-1z45A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 ILE A 518
ALA A 431
ASN A 533
VAL A 637
TYR A 696
None
1.45A 2gl0A-1z45A:
undetectable
2gl0C-1z45A:
undetectable
2gl0A-1z45A:
16.70
2gl0C-1z45A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 LEU A  31
TYR A  36
ILE A  89
ILE A 259
None
0.98A 2q8hA-1z45A:
undetectable
2q8hA-1z45A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 LEU A 591
GLY A 661
GLN A 660
THR A 549
None
0.76A 2wd9B-1z45A:
3.7
2wd9B-1z45A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 VAL A 406
GLY A 424
TYR A 415
TYR A 507
None
0.95A 3af0A-1z45A:
undetectable
3af0A-1z45A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 VAL A  57
LYS A  60
HIS A  26
None
0.96A 3elzA-1z45A:
0.5
3elzA-1z45A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 ASP A 490
LEU A 488
TYR A 520
THR A 535
ILE A 427
None
1.30A 3g4lC-1z45A:
undetectable
3g4lC-1z45A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 VAL A 637
SER A 538
ILE A 423
LEU A 635
None
0.96A 3kk6A-1z45A:
undetectable
3kk6A-1z45A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 VAL A 637
SER A 538
ILE A 423
LEU A 635
None
0.91A 3kk6B-1z45A:
undetectable
3kk6B-1z45A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 GLY A 424
ILE A 694
PHE A 540
PHE A 662
None
0.91A 3ko0B-1z45A:
undetectable
3ko0J-1z45A:
undetectable
3ko0B-1z45A:
9.59
3ko0J-1z45A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 GLY A 424
ILE A 694
PHE A 540
PHE A 662
None
0.96A 3ko0K-1z45A:
undetectable
3ko0S-1z45A:
undetectable
3ko0K-1z45A:
9.59
3ko0S-1z45A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 5 VAL A 315
LEU A 316
ILE A 149
ALA A 142
None
0.90A 3n8yB-1z45A:
undetectable
3n8yB-1z45A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 8 LEU A  44
ASP A  42
SER A  51
TYR A 371
None
NAD  A 703 (-2.7A)
None
None
1.08A 3rodA-1z45A:
5.8
3rodA-1z45A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 11 GLY A 392
GLY A 428
ILE A 427
ILE A 518
ILE A 505
None
0.87A 3s45B-1z45A:
undetectable
3s45B-1z45A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
6 / 12 GLY A 392
ALA A 393
GLY A 428
ILE A 427
ILE A 518
ILE A 505
None
1.27A 3s54B-1z45A:
undetectable
3s54B-1z45A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 PRO A 531
LEU A 448
ASN A 674
ILE A 673
None
1.04A 3u5jA-1z45A:
undetectable
3u5jA-1z45A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 9 ARG A 466
ALA A 389
GLY A 408
ILE A 423
LEU A 416
None
1.19A 3u7sB-1z45A:
undetectable
3u7sB-1z45A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 ILE A 461
GLY A 462
SER A 463
SER A 460
None
0.89A 3v7pA-1z45A:
undetectable
3v7pA-1z45A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 ARG A 144
PHE A 145
PRO A 146
None
0.35A 3zoaB-1z45A:
undetectable
3zoaB-1z45A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZF_B_ACTB502_0
(ALDOSE 1-EPIMERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 4 HIS A 458
HIS A 537
ASP A 599
TYR A 647
GAL  A 700 (-4.1A)
GAL  A 700 (-4.1A)
GAL  A 700 (-2.8A)
GAL  A 700 (-4.1A)
0.41A 4bzfB-1z45A:
32.9
4bzfB-1z45A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 4 LYS A  74
LEU A  76
GLU A  77
LEU A 121
None
1.40A 4k4yE-1z45A:
undetectable
4k4yE-1z45A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 9 THR A 553
LEU A 591
GLN A 645
PHE A 646
THR A 648
None
None
GAL  A 700 (-4.0A)
None
None
1.21A 4ltwA-1z45A:
undetectable
4ltwA-1z45A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 5 TYR A 486
ASP A  50
GLU A  56
VAL A  28
None
1.44A 4nkvB-1z45A:
0.0
4nkvB-1z45A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 9 VAL A 315
ALA A 142
ARG A 191
ILE A 151
ILE A 149
None
1.31A 4oknB-1z45A:
8.3
4oknB-1z45A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 ASN A 457
ILE A 570
ILE A 670
VAL A 565
GAL  A 700 (-3.6A)
None
None
None
1.02A 4olmA-1z45A:
undetectable
4olmA-1z45A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 THR A 640
GLU A 641
THR A 508
LEU A 616
None
1.11A 4pgfA-1z45A:
9.4
4pgfA-1z45A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 11 GLY A  18
GLY A  19
THR A  27
ASP A  42
ASP A  69
NAD  A 703 (-3.4A)
None
None
NAD  A 703 (-2.7A)
NAD  A 703 (-3.4A)
0.90A 4pghA-1z45A:
5.9
4pghA-1z45A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 GLY A 667
TYR A 644
SER A 639
ALA A 672
TYR A 430
None
1.37A 4ymgB-1z45A:
7.6
4ymgB-1z45A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 VAL A 682
VAL A 565
GLN A 645
GLU A 665
ASN A 457
None
None
GAL  A 700 (-4.0A)
GAL  A 700 (-2.7A)
GAL  A 700 (-3.6A)
1.41A 4zj8A-1z45A:
6.0
4zj8A-1z45A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 CYH A  38
GLY A  18
GLY A  19
ASP A  42
None
NAD  A 703 (-3.4A)
None
NAD  A 703 (-2.7A)
0.97A 5a06D-1z45A:
7.4
5a06D-1z45A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 LEU A 121
GLN A 123
PHE A  80
LEU A  76
None
0.96A 5b3sC-1z45A:
undetectable
5b3sJ-1z45A:
undetectable
5b3sC-1z45A:
16.74
5b3sJ-1z45A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 LEU A 121
GLN A 123
PHE A  80
LEU A  76
None
0.99A 5b3sP-1z45A:
undetectable
5b3sP-1z45A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 ASP A 247
GLU A 153
SER A 340
None
0.72A 5bw4B-1z45A:
5.4
5bw4B-1z45A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 GLU A 485
GLY A 462
ARG A 429
GLY A 428
None
0.88A 5cdnA-1z45A:
undetectable
5cdnB-1z45A:
2.7
5cdnA-1z45A:
22.07
5cdnB-1z45A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 6 GLU A 485
GLY A 462
ARG A 429
GLY A 428
None
0.91A 5cdnR-1z45A:
undetectable
5cdnS-1z45A:
2.7
5cdnR-1z45A:
22.07
5cdnS-1z45A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 5 GLY A 667
THR A 535
GLN A 645
THR A 643
None
None
GAL  A 700 (-4.0A)
None
1.20A 5h5fA-1z45A:
3.1
5h5fA-1z45A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 LEU A 121
GLN A 123
PHE A  80
LEU A  76
None
0.92A 5iy5C-1z45A:
undetectable
5iy5J-1z45A:
undetectable
5iy5C-1z45A:
16.71
5iy5J-1z45A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 LEU A 591
GLY A 661
ASN A 541
LEU A 542
ALA A 626
None
1.16A 5kbwA-1z45A:
undetectable
5kbwA-1z45A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 LEU A 591
GLY A 661
ASN A 541
ALA A 626
TYR A 647
None
None
None
None
GAL  A 700 (-4.1A)
1.19A 5kbwB-1z45A:
undetectable
5kbwB-1z45A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 LEU A 591
GLY A 661
ASN A 541
LEU A 542
ALA A 626
None
1.19A 5kc4E-1z45A:
undetectable
5kc4E-1z45A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
4 / 7 ILE A 633
PHE A 698
LYS A 544
SER A 538
None
1.44A 5nr3A-1z45A:
0.0
5nr3A-1z45A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 GLY A 691
SER A 692
ASN A 618
GLU A 619
LEU A 620
None
1.10A 5nwvA-1z45A:
undetectable
5nwvA-1z45A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 ALA A 136
VAL A  97
TYR A 163
UPG  A 704 (-3.6A)
None
NAD  A 703 ( 4.6A)
0.62A 5zmqH-1z45A:
undetectable
5zmqH-1z45A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
5 / 12 GLY A 392
GLY A 428
ILE A 427
ILE A 518
ILE A 505
None
0.95A 6dh3A-1z45A:
undetectable
6dh3A-1z45A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae)
3 / 3 LEU A 524
GLY A 522
PHE A 464
None
0.67A 6exiC-1z45A:
8.6
6exiC-1z45A:
9.25