SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 5 HIS A 105
GLU A 145
ALA A 149
HIS A  81
 None
 1.02A 1errA-1z48A:
undetectable
1errB-1z48A:
undetectable		 1errA-1z48A:
22.06
1errB-1z48A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 12 GLY A 251
VAL A 254
SER A 249
GLY A 225
HIS A 231
 None
None
FMN  A1500 ( 4.4A)
None
None
 1.09A 1nbiA-1z48A:
undetectable		 1nbiA-1z48A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 12 GLY A 251
VAL A 254
SER A 249
GLY A 225
HIS A 231
 None
None
FMN  A1500 ( 4.4A)
None
None
 1.10A 1nbiB-1z48A:
undetectable		 1nbiB-1z48A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		3 / 3 ASP A 302
VAL A  21
PRO A  24
 None
None
FMN  A1500 (-4.1A)
 0.73A 2avvA-1z48A:
undetectable		 2avvA-1z48A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 7 ARG A 182
VAL A 214
LEU A 226
ILE A 163
 None
 0.94A 3gp0A-1z48A:
undetectable		 3gp0A-1z48A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 11 ILE A  57
ASP A 247
PHE A 213
ILE A   9
LEU A  55
 None
 1.21A 3qg2B-1z48A:
undetectable		 3qg2B-1z48A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 8 ALA A 252
SER A 217
SER A 249
TYR A 169
 None
None
FMN  A1500 ( 4.4A)
None
 1.03A 3rodA-1z48A:
undetectable		 3rodA-1z48A:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 9 ALA A 104
HIS A 164
HIS A 167
TYR A 169
TYR A  28
 None
FMN  A1500 (-3.9A)
FMN  A1500 (-4.3A)
None
None
 1.27A 3upwA-1z48A:
36.9		 3upwA-1z48A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 6 HIS A 164
SER A 217
GLU A 173
ASP A 125
 FMN  A1500 (-3.9A)
None
None
None
 1.28A 4blvA-1z48A:
undetectable		 4blvA-1z48A:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 6 HIS A 164
HIS A 167
TYR A 169
TYR A  28
 FMN  A1500 (-3.9A)
FMN  A1500 (-4.3A)
None
None
 0.87A 4df2A-1z48A:
36.8		 4df2A-1z48A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 12 GLU A 162
ARG A 215
ILE A  20
GLY A  54
LEU A  16
 None
FMN  A1500 (-3.2A)
None
None
None
 1.27A 4j26A-1z48A:
undetectable		 4j26A-1z48A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 7 ASP A 220
SER A 179
HIS A 172
SER A 176
 None
 1.05A 4k7gB-1z48A:
0.2		 4k7gB-1z48A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 4 ILE A 295
VAL A 283
VAL A 266
ARG A 300
 None
FMN  A1500 (-4.5A)
None
None
 1.02A 4m6tA-1z48A:
undetectable		 4m6tA-1z48A:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 5 CYH A  26
ILE A  69
HIS A 164
HIS A 167
TYR A 169
 FMN  A1500 (-2.9A)
None
FMN  A1500 (-3.9A)
FMN  A1500 (-4.3A)
None
 0.17A 5ocsA-1z48A:
50.2		 5ocsA-1z48A:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 5 CYH A  26
ILE A  69
HIS A 164
HIS A 167
TYR A 169
 FMN  A1500 (-2.9A)
None
FMN  A1500 (-3.9A)
FMN  A1500 (-4.3A)
None
 0.16A 5ocsC-1z48A:
50.2		 5ocsC-1z48A:
38.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 8 GLU A 162
VAL A 160
GLY A 281
LEU A 303
 None
 1.01A 5sxqA-1z48A:
undetectable		 5sxqA-1z48A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		3 / 3 ASP A 220
PHE A 234
ARG A 193
 None
 0.90A 5yw0A-1z48A:
undetectable		 5yw0A-1z48A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 12 PRO A 331
TYR A 334
GLN A 333
GLN A  95
ALA A  43
 None
 1.39A 5zovB-1z48A:
0.0		 5zovB-1z48A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 5 GLN A 102
VAL A 214
PRO A  24
THR A 280
 FMN  A1500 (-2.9A)
None
FMN  A1500 (-4.1A)
None
 1.49A 6cduA-1z48A:
0.0
6cduB-1z48A:
0.0		 6cduA-1z48A:
22.81
6cduB-1z48A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 8 GLN A  52
VAL A  53
PRO A 331
ILE A  56
 None
 1.05A 6cduG-1z48A:
undetectable
6cduH-1z48A:
undetectable		 6cduG-1z48A:
22.81
6cduH-1z48A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		4 / 7 ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
FMN  A1500 (-3.3A)
 0.76A 6nm4A-1z48A:
undetectable		 6nm4A-1z48A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM
(Bacillus
subtilis) 		5 / 9 ILE A 295
ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
None
FMN  A1500 (-3.3A)
 1.02A 6nm4B-1z48A:
undetectable		 6nm4B-1z48A:
19.88