SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 10 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.17A 1j3jA-1z4eA:
undetectable		 1j3jA-1z4eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 9 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.21A 1j3jB-1z4eA:
undetectable		 1j3jB-1z4eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 11 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.19A 2blaA-1z4eA:
undetectable		 2blaA-1z4eA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 10 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.19A 3clbD-1z4eA:
2.1		 3clbD-1z4eA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 10 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.19A 3hbbD-1z4eA:
2.6		 3hbbD-1z4eA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 10 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.22A 3qgtA-1z4eA:
undetectable		 3qgtA-1z4eA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 10 ALA A  10
ASP A  14
ILE A 102
ILE A   7
THR A  11
 None
 1.22A 3qgtB-1z4eA:
undetectable		 3qgtB-1z4eA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		3 / 3 MET A  69
GLU A  32
ARG A  92
 None
 1.06A 5tjyA-1z4eA:
undetectable		 5tjyA-1z4eA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1z4e TRANSCRIPTIONAL
REGULATOR
(Bacillus
halodurans) 		5 / 12 ARG A 135
PHE A 136
LEU A  70
ILE A 111
ALA A 144
 None
 1.07A 5vc0A-1z4eA:
undetectable		 5vc0A-1z4eA:
14.17