SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 11 VAL A  24
TYR A  28
GLY A  60
LEU A  59
VAL A  75
 None
 1.43A 1i9jH-1z54A:
undetectable
1i9jL-1z54A:
undetectable		 1i9jH-1z54A:
18.39
1i9jL-1z54A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 10 LEU A  37
ALA A  40
LEU A 129
LEU A  79
ILE A 118
 None
 1.20A 1pcgA-1z54A:
undetectable		 1pcgA-1z54A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		4 / 8 THR A 105
LEU A  59
VAL A  75
VAL A  93
 None
 0.91A 1t86A-1z54A:
undetectable		 1t86A-1z54A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 12 GLU A  71
TYR A  25
ILE A   7
VAL A  73
TYR A  28
 None
 1.37A 2qeoA-1z54A:
undetectable		 2qeoA-1z54A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 10 THR A 105
LEU A  59
LEU A  61
VAL A  75
VAL A  93
 None
 1.19A 3lxiA-1z54A:
undetectable		 3lxiA-1z54A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 11 THR A 105
LEU A  59
LEU A  61
VAL A  75
VAL A  93
 None
 1.21A 3lxiB-1z54A:
undetectable		 3lxiB-1z54A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 11 PHE A  89
LEU A  87
PHE A  54
HIS A 107
TYR A  44
 None
None
None
GOL  A 502 ( 4.9A)
GOL  A 502 (-4.8A)
 1.38A 3o94A-1z54A:
undetectable		 3o94A-1z54A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 11 PHE A  89
LEU A  87
PHE A  54
HIS A 107
TYR A  44
 None
None
None
GOL  A 502 ( 4.9A)
GOL  A 502 (-4.8A)
 1.39A 3o94C-1z54A:
undetectable		 3o94C-1z54A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		5 / 11 PHE A  89
LEU A  87
PHE A  54
HIS A 107
TYR A  44
 None
None
None
GOL  A 502 ( 4.9A)
GOL  A 502 (-4.8A)
 1.38A 3o94D-1z54A:
undetectable		 3o94D-1z54A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1z54 PROBABLE
THIOESTERASE
(Thermus
thermophilus) 		3 / 3 HIS A  45
ARG A  46
GLU A  38
 None
 1.07A 3qf1A-1z54A:
undetectable		 3qf1A-1z54A:
12.73