SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 9 ASN A  42
ASP A  76
ILE A  81
PRO A  82
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 (-3.7A)
ADP  A2001 (-4.5A)
None
ADP  A2001 ( 3.9A)
 0.65A 1aj6A-1z5aA:
17.6		 1aj6A-1z5aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.20A 1cmcA-1z5aA:
undetectable
1cmcB-1z5aA:
undetectable		 1cmcA-1z5aA:
13.27
1cmcB-1z5aA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 4 HIS A 348
VAL A 100
ASN A 101
THR A 418
 None
 1.47A 1dy5A-1z5aA:
undetectable		 1dy5A-1z5aA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 8 ALA A 335
GLY A 360
ALA A 357
ILE A 362
 None
 0.70A 1gtnI-1z5aA:
undetectable
1gtnJ-1z5aA:
undetectable		 1gtnI-1z5aA:
11.18
1gtnJ-1z5aA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.21A 1mj2A-1z5aA:
undetectable
1mj2B-1z5aA:
undetectable		 1mj2A-1z5aA:
13.50
1mj2B-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.27A 1mjoC-1z5aA:
undetectable
1mjoD-1z5aA:
undetectable		 1mjoC-1z5aA:
13.50
1mjoD-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ARG A 193
LEU A 371
HIS A 414
PRO A 378
GLY A 318
 None
 1.28A 1mjqA-1z5aA:
undetectable
1mjqB-1z5aA:
undetectable		 1mjqA-1z5aA:
13.50
1mjqB-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.31A 1mjqA-1z5aA:
undetectable
1mjqB-1z5aA:
undetectable		 1mjqA-1z5aA:
13.50
1mjqB-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 ARG A 193
LEU A 371
HIS A 414
PRO A 378
GLY A 318
 None
 1.27A 1mjqC-1z5aA:
undetectable
1mjqD-1z5aA:
undetectable		 1mjqC-1z5aA:
13.50
1mjqD-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.30A 1mjqG-1z5aA:
undetectable
1mjqH-1z5aA:
undetectable		 1mjqG-1z5aA:
13.50
1mjqH-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ARG A 193
LEU A 371
HIS A 414
PRO A 378
GLY A 318
 None
 1.26A 1mjqI-1z5aA:
undetectable
1mjqJ-1z5aA:
undetectable		 1mjqI-1z5aA:
13.50
1mjqJ-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 9 LEU A 451
LEU A 326
VAL A 411
GLY A 355
ALA A 354
 None
 1.19A 1pxxB-1z5aA:
undetectable		 1pxxB-1z5aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 LEU A 451
LEU A 326
VAL A 411
GLY A 355
ALA A 354
 None
 1.18A 1pxxD-1z5aA:
undetectable		 1pxxD-1z5aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN A  42
SER A  43
ASP A  45
ASP A  76
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
ADP  A2001 ( 3.9A)
 0.36A 1s14A-1z5aA:
15.4		 1s14A-1z5aA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 LEU A  32
PRO A 208
TYR A 188
ILE A 187
VAL A  36
 None
 1.33A 1tmxB-1z5aA:
undetectable		 1tmxB-1z5aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		3 / 3 TYR A 422
ASP A 386
HIS A 414
 None
 0.86A 3e23A-1z5aA:
undetectable		 3e23A-1z5aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 VAL A 172
ILE A  69
VAL A 116
VAL A 112
LEU A  39
 None
None
None
ADP  A2001 (-4.0A)
None
 1.05A 3gwxA-1z5aA:
undetectable		 3gwxA-1z5aA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN A  42
SER A  43
ASP A  45
ASP A  76
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
ADP  A2001 ( 3.9A)
 0.33A 3lpsA-1z5aA:
20.2		 3lpsA-1z5aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 SER A  43
ASP A  45
ASP A  76
PRO A  82
THR A 170
 ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
None
ADP  A2001 ( 3.9A)
 0.73A 3lpsA-1z5aA:
20.2		 3lpsA-1z5aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 7 PHE A  90
LEU A  39
ASN A  42
ILE A 174
 ADP  A2001 ( 4.5A)
None
MG  A1001 ( 2.6A)
None
 0.93A 3rfmA-1z5aA:
undetectable		 3rfmA-1z5aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		3 / 3 LEU A  39
GLU A  41
SER A  43
 None
None
ADP  A2001 ( 3.9A)
 0.83A 4ccqA-1z5aA:
undetectable		 4ccqA-1z5aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ILE A 197
LYS A 376
LEU A  44
ARG A 105
TYR A  33
 None
 1.18A 4cd2A-1z5aA:
undetectable		 4cd2A-1z5aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 5 ILE A 146
LEU A 117
LYS A 113
ASN A 151
 None
None
ADP  A2001 (-2.7A)
None
 0.95A 4g19A-1z5aA:
undetectable		 4g19A-1z5aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN A  42
SER A  43
ASP A  45
ASP A  76
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
ADP  A2001 ( 3.9A)
 0.32A 4urnA-1z5aA:
17.5		 4urnA-1z5aA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN A  42
SER A  43
ASP A  45
ASP A  76
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
ADP  A2001 ( 3.9A)
 0.30A 4urnB-1z5aA:
16.6		 4urnB-1z5aA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN A  42
SER A  43
ASP A  45
ASP A  76
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
None
ADP  A2001 (-3.7A)
ADP  A2001 ( 3.9A)
 0.28A 4urnC-1z5aA:
17.7		 4urnC-1z5aA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN A  42
SER A  43
ASP A  76
ILE A  81
GLN A  84
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
ADP  A2001 (-3.7A)
ADP  A2001 (-4.5A)
None
 1.30A 4uroB-1z5aA:
17.3		 4uroB-1z5aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN A  42
SER A  43
ASP A  76
ILE A  81
THR A 170
 MG  A1001 ( 2.6A)
ADP  A2001 ( 3.9A)
ADP  A2001 (-3.7A)
ADP  A2001 (-4.5A)
ADP  A2001 ( 3.9A)
 0.58A 4uroD-1z5aA:
17.6		 4uroD-1z5aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 SER A  43
ASP A  76
ILE A  81
PRO A  82
THR A 170
 ADP  A2001 ( 3.9A)
ADP  A2001 (-3.7A)
ADP  A2001 (-4.5A)
None
ADP  A2001 ( 3.9A)
 0.76A 4uroD-1z5aA:
17.6		 4uroD-1z5aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 8 ILE A 187
ALA A  29
ARG A  30
ASP A 382
 None
 1.02A 6hu9a-1z5aA:
0.0
6hu9e-1z5aA:
0.9		 6hu9a-1z5aA:
22.09
6hu9e-1z5aA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 6 ILE A 187
ALA A  29
ARG A  30
ASP A 382
 None
 1.10A 6hu9m-1z5aA:
undetectable
6hu9q-1z5aA:
0.9		 6hu9m-1z5aA:
22.09
6hu9q-1z5aA:
14.38