SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.03A 1qzfA-1z5vA:
undetectable		 1qzfA-1z5vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.04A 1qzfB-1z5vA:
undetectable		 1qzfB-1z5vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.04A 1qzfC-1z5vA:
undetectable		 1qzfC-1z5vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.03A 1qzfD-1z5vA:
undetectable		 1qzfD-1z5vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.04A 1qzfE-1z5vA:
undetectable		 1qzfE-1z5vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		3 / 3 LEU A 205
HIS A 139
ILE A 141
 None
 0.49A 1s9pB-1z5vA:
undetectable		 1s9pB-1z5vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 5 ALA A  55
TYR A  60
ILE A  61
ASP A  49
 None
 1.12A 1upfA-1z5vA:
3.6		 1upfA-1z5vA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 11 LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 1.03A 2bxmA-1z5vA:
undetectable		 2bxmA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 10 LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 1.04A 2bxqA-1z5vA:
0.0		 2bxqA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 PHE A  51
ILE A   6
LEU A 157
ALA A  64
ASP A 200
 None
 1.39A 2iyfB-1z5vA:
4.6		 2iyfB-1z5vA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 5 PRO A 365
ILE A  36
GLY A  30
TYR A 366
 None
 1.11A 2jkjD-1z5vA:
undetectable		 2jkjD-1z5vA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 5 PRO A 365
ILE A  36
GLY A  30
TYR A 366
 None
 1.11A 2jkjF-1z5vA:
undetectable		 2jkjF-1z5vA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A  14
GLY A  11
GLY A 144
ILE A  17
 None
None
GSP  A2466 (-3.1A)
GSP  A2466 (-3.0A)
None
 0.99A 2oxtA-1z5vA:
undetectable		 2oxtA-1z5vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 8 LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 1.16A 3b9lA-1z5vA:
undetectable		 3b9lA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 5 ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 0.87A 3b9mA-1z5vA:
undetectable		 3b9mA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 146
GLY A 144
ILE A 118
ASP A  68
LEU A  67
 GSP  A2466 (-4.0A)
GSP  A2466 (-3.0A)
None
MG  A 475 ( 4.0A)
None
 0.91A 3ihtA-1z5vA:
2.2		 3ihtA-1z5vA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 11 LEU A 153
GLY A 146
LEU A  67
ASN A  15
LEU A  69
 None
GSP  A2466 (-4.0A)
None
None
None
 1.16A 3ndvA-1z5vA:
0.0
3ndvB-1z5vA:
0.0		 3ndvA-1z5vA:
19.39
3ndvB-1z5vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 ASN A 417
GLY A 148
GLU A 155
GLY A 150
LEU A 192
 None
 0.98A 3nk7B-1z5vA:
undetectable		 3nk7B-1z5vA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.28A 4c49A-1z5vA:
undetectable		 4c49A-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.28A 4c49B-1z5vA:
undetectable		 4c49B-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.23A 4c49C-1z5vA:
undetectable		 4c49C-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.30A 4c49D-1z5vA:
undetectable		 4c49D-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A  25
THR A   7
ILE A   5
LEU A 253
THR A 234
 None
 1.13A 4kebB-1z5vA:
undetectable		 4kebB-1z5vA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 166
LEU A 132
GLY A 134
ILE A 122
LEU A   8
 None
 1.18A 4o5fA-1z5vA:
0.2
4o5fB-1z5vA:
1.5		 4o5fA-1z5vA:
21.67
4o5fB-1z5vA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A   8
VAL A 166
LEU A 132
GLY A 134
ILE A 122
 None
 1.21A 4o5fA-1z5vA:
undetectable
4o5fB-1z5vA:
undetectable		 4o5fA-1z5vA:
21.67
4o5fB-1z5vA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 166
LEU A 132
GLY A 134
ILE A 122
LEU A   8
 None
 1.24A 5b8hA-1z5vA:
undetectable
5b8hB-1z5vA:
undetectable		 5b8hA-1z5vA:
20.31
5b8hB-1z5vA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A   8
VAL A 166
LEU A 132
GLY A 134
ILE A 122
 None
 1.23A 5b8hA-1z5vA:
undetectable
5b8hB-1z5vA:
undetectable		 5b8hA-1z5vA:
20.31
5b8hB-1z5vA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A 144
GLY A  11
LEU A  10
ALA A 105
 None
GSP  A2466 (-3.0A)
GSP  A2466 (-3.1A)
None
None
 0.91A 5c0oE-1z5vA:
2.9		 5c0oE-1z5vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A 144
GLY A  11
LEU A  10
ALA A 105
 None
GSP  A2466 (-3.0A)
GSP  A2466 (-3.1A)
None
None
 0.90A 5c0oG-1z5vA:
2.1		 5c0oG-1z5vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 ASP A 292
LEU A 291
SER A 336
VAL A 373
VAL A 328
 None
 1.17A 5dpdB-1z5vA:
undetectable		 5dpdB-1z5vA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 6 LEU A  66
THR A   7
GLN A 167
MET A 236
 None
 1.46A 5h8tA-1z5vA:
undetectable		 5h8tA-1z5vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		4 / 7 GLY A  18
VAL A  73
ASP A  68
ILE A  74
 None
None
MG  A 475 ( 4.0A)
None
 0.72A 5ik1A-1z5vA:
undetectable		 5ik1A-1z5vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		3 / 3 CYH A 316
LYS A 313
HIS A 315
 None
 1.28A 5js5A-1z5vA:
undetectable		 5js5A-1z5vA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A 149
GLY A  11
LEU A 153
LEU A 157
LEU A   8
 None
GSP  A2466 (-3.1A)
None
None
None
 0.98A 5nfjA-1z5vA:
2.6		 5nfjA-1z5vA:
16.42