SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		3 / 3 ARG E 156
TYR E 179
LYS E 178
 None
 0.79A 1uujB-1z5yE:
undetectable		 1uujB-1z5yE:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		5 / 12 LEU E  90
ASN E  91
LEU E  93
VAL E  71
LEU E 116
 None
 1.06A 2oz7A-1z5yE:
undetectable		 2oz7A-1z5yE:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		4 / 5 HIS E  87
LEU E 127
LEU E  73
ASP E 129
 None
 1.27A 4aqlA-1z5yE:
undetectable		 4aqlA-1z5yE:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		4 / 6 VAL E 101
VAL E  71
ILE E 149
LEU E 138
 None
 0.99A 4l1wB-1z5yE:
undetectable		 4l1wB-1z5yE:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		3 / 3 TRP E  79
GLN E 110
THR E  78
 None
 0.88A 4m2xA-1z5yE:
undetectable		 4m2xA-1z5yE:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		4 / 8 LEU E 136
GLY E 135
GLU E 145
ALA E 143
 None
 0.80A 4rjdA-1z5yE:
undetectable
4rjdB-1z5yE:
undetectable		 4rjdA-1z5yE:
17.02
4rjdB-1z5yE:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		3 / 3 HIS E  87
GLU E  86
TRP E  76
 None
 1.12A 5odiD-1z5yE:
undetectable		 5odiD-1z5yE:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		3 / 3 HIS E  87
GLU E  86
TRP E  76
 None
 1.15A 5odrD-1z5yE:
undetectable		 5odrD-1z5yE:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		4 / 8 PRO E 174
GLU E 170
TRP E 168
TYR E  89
 None
 1.44A 5oh1C-1z5yE:
undetectable		 5oh1C-1z5yE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE
(Escherichia
coli) 		4 / 8 PRO E 174
GLU E 171
TRP E 168
TYR E  89
 None
 1.42A 5oh1C-1z5yE:
undetectable		 5oh1C-1z5yE:
22.36