SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ALA A 809
VAL A 807
TRP A 828
 None
 0.71A 1av2C-1z5zA:
undetectable
1av2D-1z5zA:
undetectable		 1av2C-1z5zA:
3.82
1av2D-1z5zA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 CYH A 670
GLU A 862
ASP A 866
ILE A 823
PHE A 825
 None
 1.35A 1oltA-1z5zA:
undetectable		 1oltA-1z5zA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ALA A 809
VAL A 807
TRP A 828
 None
 0.63A 1w5uC-1z5zA:
undetectable
1w5uD-1z5zA:
undetectable		 1w5uC-1z5zA:
3.82
1w5uD-1z5zA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 TRP A 828
LEU A 855
LYS A 732
 None
 1.02A 1yajK-1z5zA:
undetectable		 1yajK-1z5zA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 TRP A 828
ALA A 809
VAL A 807
 None
 0.56A 2izqA-1z5zA:
undetectable
2izqB-1z5zA:
undetectable		 2izqA-1z5zA:
3.82
2izqB-1z5zA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ALA A 809
VAL A 807
TRP A 828
 None
 0.52A 3l8lA-1z5zA:
undetectable
3l8lB-1z5zA:
undetectable		 3l8lA-1z5zA:
3.82
3l8lB-1z5zA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ALA A 809
VAL A 807
TRP A 828
 None
 0.57A 3l8lC-1z5zA:
undetectable
3l8lD-1z5zA:
undetectable		 3l8lC-1z5zA:
3.82
3l8lD-1z5zA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 8 LEU A 895
SER A 891
LEU A 704
ILE A 691
 None
 0.88A 3ln1A-1z5zA:
undetectable		 3ln1A-1z5zA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 7 LEU A 895
SER A 891
LEU A 704
ILE A 691
 None
 0.87A 3ln1B-1z5zA:
undetectable		 3ln1B-1z5zA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 TRP A 828
GLN A 712
THR A 754
 None
 0.95A 4m2xA-1z5zA:
undetectable		 4m2xA-1z5zA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 GLU A 834
ASP A 866
LEU A 861
ASP A 884
ILE A 887
 None
 1.14A 6fzbB-1z5zA:
0.0		 6fzbB-1z5zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1z5z HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 10 PHE A 825
MET A 759
TYR A 779
PHE A 777
VAL A 804
 None
 1.38A 6hu9C-1z5zA:
2.4		 6hu9C-1z5zA:
22.22