SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 11 LEU A 492
ARG A 456
LEU A 518
HIS A 517
ALA A 481
 None
 1.36A 1hk1A-1z63A:
2.3		 1hk1A-1z63A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 TRP A 828
LEU A 855
LYS A 732
 None
 0.95A 1yajK-1z63A:
undetectable		 1yajK-1z63A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 7 PHE A 871
LEU A 890
SER A 891
TRP A 886
 None
 0.91A 3hs6B-1z63A:
undetectable		 3hs6B-1z63A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ASN A 566
ASP A 562
ARG A 821
 None
 0.92A 3k13A-1z63A:
undetectable		 3k13A-1z63A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 6 LEU A 492
SER A 484
PHE A 483
ILE A 537
 None
 0.99A 3ko0B-1z63A:
undetectable		 3ko0B-1z63A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 4 VAL A 522
PHE A 520
PHE A 483
VAL A 560
 None
 1.37A 3rv5C-1z63A:
undetectable
3rv5D-1z63A:
2.2		 3rv5C-1z63A:
10.86
3rv5D-1z63A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 8 ILE A 767
ILE A 750
PHE A 802
GLU A 738
 None
 0.85A 3ua5A-1z63A:
undetectable		 3ua5A-1z63A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 ARG A 827
ARG A 873
ASP A 835
 None
 0.97A 3wipG-1z63A:
undetectable
3wipH-1z63A:
undetectable		 3wipG-1z63A:
19.22
3wipH-1z63A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 7 THR A 838
TRP A 828
HIS A 824
LEU A 816
 None
 1.28A 4awuA-1z63A:
undetectable		 4awuA-1z63A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 PHE A 514
VAL A 497
ILE A 537
 None
 0.63A 4emaA-1z63A:
undetectable		 4emaA-1z63A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 8 ILE A 538
VAL A 578
ILE A 574
PHE A 523
 None
 0.83A 4r38D-1z63A:
undetectable		 4r38D-1z63A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 11 ASN A 596
LEU A 601
GLU A 636
ALA A 634
LEU A 638
 None
 1.10A 4wg0J-1z63A:
undetectable
4wg0K-1z63A:
undetectable
4wg0L-1z63A:
undetectable		 4wg0J-1z63A:
2.75
4wg0K-1z63A:
2.75
4wg0L-1z63A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		4 / 5 LEU A 467
GLY A 451
ASP A 653
ILE A 656
 None
 1.02A 5ik1A-1z63A:
undetectable		 5ik1A-1z63A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1z63 HELICASE OF THE
SNF2/RAD54 FAMILY
(Sulfolobus
solfataricus) 		5 / 10 PHE A 825
MET A 759
TYR A 779
PHE A 777
VAL A 804
 None
 1.38A 6hu9C-1z63A:
2.1		 6hu9C-1z63A:
20.16