SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 4 ILE A 190
MET A 162
VAL A  62
GLY A 167
 None
F42  A 328 (-4.7A)
F42  A 328 (-4.4A)
None
 1.08A 1e06B-1z69A:
undetectable		 1e06B-1z69A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 10 GLY A  61
GLN A 302
TYR A 209
TYR A 154
THR A  34
 None
None
F42  A 328 ( 4.0A)
None
F42  A 328 (-4.1A)
 1.22A 1kvlA-1z69A:
undetectable		 1kvlA-1z69A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 7 PHE A 183
ALA A 177
ILE A 303
ILE A 281
 None
 0.94A 1oniD-1z69A:
undetectable
1oniF-1z69A:
undetectable		 1oniD-1z69A:
19.69
1oniF-1z69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 258
ALA A 257
PHE A 263
LEU A 266
ALA A 265
 None
 1.05A 1xdkA-1z69A:
undetectable		 1xdkA-1z69A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 258
ALA A 257
PHE A 263
LEU A 266
ALA A 265
 None
 1.04A 1xdkE-1z69A:
undetectable		 1xdkE-1z69A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 HIS A  36
LEU A  46
VAL A  48
PRO A   9
ILE A  16
 F42  A 328 (-3.8A)
None
None
None
None
 1.09A 1zq9A-1z69A:
undetectable		 1zq9A-1z69A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 LEU A 163
ASP A 205
GLY A 299
ILE A 298
ILE A 190
 None
 0.95A 2o4kA-1z69A:
undetectable		 2o4kA-1z69A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 11 ARG A 243
ALA A 186
ILE A 298
ILE A 175
ALA A 177
 None
 1.05A 2qhfA-1z69A:
undetectable		 2qhfA-1z69A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 11 ALA A 316
LEU A 319
PHE A  28
ILE A 324
PRO A 285
 None
 1.16A 3bpxA-1z69A:
undetectable
3bpxB-1z69A:
undetectable		 3bpxA-1z69A:
19.00
3bpxB-1z69A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 4 GLY A  91
TYR A 154
GLY A 172
ASP A 171
 None
 1.15A 3kl3A-1z69A:
10.6		 3kl3A-1z69A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ALA A  88
LEU A  90
ALA A  74
ALA A 148
ILE A 121
 None
 1.13A 3ut5D-1z69A:
undetectable		 3ut5D-1z69A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		3 / 3 ASN A 176
LEU A 295
PHE A 279
 F42  A 328 (-3.9A)
None
None
 0.71A 4dajB-1z69A:
undetectable		 4dajB-1z69A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 8 GLY A  95
THR A  67
TYR A  66
ASN A  64
 F42  A 328 (-3.0A)
None
None
None
 1.26A 4m5mA-1z69A:
undetectable		 4m5mA-1z69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 10 LEU A  92
LEU A  90
GLY A  91
ASP A  35
ILE A 121
 None
 1.15A 4xj7C-1z69A:
undetectable
4xj7D-1z69A:
undetectable		 4xj7C-1z69A:
24.07
4xj7D-1z69A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ALA A 166
GLY A  91
ALA A 170
THR A 114
ILE A 153
 None
 1.07A 5eeuI-1z69A:
undetectable
5eeuJ-1z69A:
undetectable		 5eeuI-1z69A:
14.37
5eeuJ-1z69A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ALA A 166
GLY A  91
ALA A 170
THR A 114
ILE A 153
 None
 1.07A 5eevI-1z69A:
undetectable
5eevJ-1z69A:
undetectable		 5eevI-1z69A:
14.37
5eevJ-1z69A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ALA A 166
GLY A  91
ALA A 170
THR A 114
ILE A 153
 None
 1.07A 5eewI-1z69A:
undetectable
5eewJ-1z69A:
undetectable		 5eewI-1z69A:
14.37
5eewJ-1z69A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 7 GLY A  93
GLY A  95
THR A 114
ALA A 117
 F42  A 328 ( 4.2A)
F42  A 328 (-3.0A)
None
None
 0.74A 5o96C-1z69A:
5.3		 5o96C-1z69A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 258
ALA A 257
PHE A 263
LEU A 266
ALA A 265
 None
 1.00A 5uanA-1z69A:
undetectable		 5uanA-1z69A:
22.51