SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLU A 138
ASP A  67
HIS A  81
LEU A 131
GLY A  16
 None
 1.19A 1d4fB-1z6mA:
0.6		 1d4fB-1z6mA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A  10
ILE A 151
THR A  15
 None
 0.76A 1rx3A-1z6mA:
undetectable		 1rx3A-1z6mA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 CYH A  39
PHE A  43
PHE A  99
 None
 0.81A 3cr5X-1z6mA:
undetectable		 3cr5X-1z6mA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 7 MET A  98
LEU A 123
LEU A  65
PHE A  99
 None
 1.24A 3nk2X-1z6mA:
undetectable		 3nk2X-1z6mA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A  10
ILE A 151
THR A  15
 None
 0.73A 4gh8A-1z6mA:
undetectable		 4gh8A-1z6mA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 TYR A  38
GLN A 102
TRP A  42
 None
 0.90A 4kn2C-1z6mA:
undetectable		 4kn2C-1z6mA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1z6m CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 6 ALA A  91
GLN A  90
LEU A  95
LEU A 123
 None
 1.25A 4xp3A-1z6mA:
undetectable		 4xp3A-1z6mA:
19.83