SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 395
LEU A 415
VAL A 411
LEU A 389
 None
 0.82A 1cqpA-1z6tA:
undetectable
1cqpB-1z6tA:
undetectable		 1cqpA-1z6tA:
16.18
1cqpB-1z6tA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.97A 1hrkA-1z6tA:
2.3		 1hrkA-1z6tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.97A 1hrkB-1z6tA:
2.3		 1hrkB-1z6tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 GLU A  78
HIS A  77
ASP A 427
 None
 0.50A 1i9gA-1z6tA:
undetectable		 1i9gA-1z6tA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 ASP A 392
ASP A 243
LYS A 198
 None
ADP  A 900 ( 4.7A)
None
 1.06A 1lqtB-1z6tA:
1.5		 1lqtB-1z6tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 ASP A 392
ASP A 243
LYS A 198
 None
ADP  A 900 ( 4.7A)
None
 1.08A 1lquB-1z6tA:
1.6		 1lquB-1z6tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A 529
GLU A 528
HIS A 521
SER A 193
 None
 1.34A 1nx9A-1z6tA:
undetectable		 1nx9A-1z6tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A 529
GLU A 528
HIS A 521
SER A 193
 None
 1.34A 1nx9B-1z6tA:
undetectable		 1nx9B-1z6tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A 529
GLU A 528
HIS A 521
SER A 193
 None
 1.34A 1nx9C-1z6tA:
undetectable		 1nx9C-1z6tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A 529
GLU A 528
HIS A 521
SER A 193
 None
 1.33A 1nx9D-1z6tA:
undetectable		 1nx9D-1z6tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 CYH A 480
TYR A 484
HIS A 468
TRP A 509
 None
 1.24A 1yvmA-1z6tA:
undetectable		 1yvmA-1z6tA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 10 ALA A 164
ALA A 167
LEU A 173
LEU A 140
VAL A 150
 None
 1.16A 2bxeA-1z6tA:
undetectable		 2bxeA-1z6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 6 LEU A 195
TRP A 149
MET A 231
LEU A 240
 None
 1.39A 2oz7A-1z6tA:
0.8		 2oz7A-1z6tA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 415
VAL A 395
LEU A 487
LEU A 473
HIS A 468
 None
 1.35A 3b0wB-1z6tA:
undetectable		 3b0wB-1z6tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 11 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.12A 3bgrA-1z6tA:
1.1
3bgrB-1z6tA:
0.8		 3bgrA-1z6tA:
23.05
3bgrB-1z6tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 11 VAL A 162
LEU A 163
GLY A 159
SER A 320
PRO A 321
 ADP  A 900 (-3.8A)
None
ADP  A 900 (-3.2A)
None
ADP  A 900 (-4.0A)
 1.13A 3bjwE-1z6tA:
undetectable		 3bjwE-1z6tA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 ASN A  73
THR A 107
VAL A 110
LEU A  87
ILE A  91
 None
 1.23A 3elzA-1z6tA:
undetectable		 3elzA-1z6tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
LEU A 163
ILE A 152
ALA A 165
ASP A 243
 ADP  A 900 (-3.2A)
None
None
None
ADP  A 900 ( 4.7A)
 1.00A 3gwwA-1z6tA:
undetectable		 3gwwA-1z6tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 ALA A 223
LEU A 230
LEU A 199
ILE A 260
CYH A 258
 None
 0.85A 3h0aA-1z6tA:
undetectable		 3h0aA-1z6tA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 ADP  A 900 (-3.8A)
None
None
None
 1.19A 3jx2A-1z6tA:
undetectable
3jx2B-1z6tA:
undetectable		 3jx2A-1z6tA:
20.17
3jx2B-1z6tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
ADP  A 900 (-3.8A)
None
 1.20A 3nlqA-1z6tA:
undetectable
3nlqB-1z6tA:
undetectable		 3nlqA-1z6tA:
20.17
3nlqB-1z6tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 LEU A 566
LEU A 554
GLU A 515
PRO A 559
 None
 0.92A 3s56B-1z6tA:
undetectable		 3s56B-1z6tA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 330
LEU A 331
LEU A 295
ILE A 370
 None
 0.87A 4klaA-1z6tA:
undetectable		 4klaA-1z6tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 8 ARG A 557
ARG A 215
GLU A 221
ARG A 226
 None
 1.18A 4kr4C-1z6tA:
undetectable		 4kr4C-1z6tA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 SER A 371
MET A 368
ASP A 381
 None
 0.90A 4mm4B-1z6tA:
0.0		 4mm4B-1z6tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 5 GLN A 259
LEU A 239
SER A 238
ASP A 225
 None
 1.09A 4qtuD-1z6tA:
undetectable		 4qtuD-1z6tA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
 0.98A 4xiwB-1z6tA:
undetectable
4xiwE-1z6tA:
undetectable		 4xiwB-1z6tA:
17.86
4xiwE-1z6tA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
 1.13A 4xiwB-1z6tA:
undetectable
4xiwE-1z6tA:
undetectable		 4xiwB-1z6tA:
17.86
4xiwE-1z6tA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 GLU A  78
HIS A  77
ASP A 427
 None
 0.60A 5c0oG-1z6tA:
2.1		 5c0oG-1z6tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.20A 5cymA-1z6tA:
undetectable		 5cymA-1z6tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.20A 5cyqA-1z6tA:
undetectable		 5cyqA-1z6tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 LEU A  16
LEU A  75
ARG A  44
 None
 0.56A 5hnzB-1z6tA:
undetectable		 5hnzB-1z6tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 ASP A 439
ASP A 244
GLY A 157
TYR A 359
 None
None
ADP  A 900 (-3.4A)
None
 0.97A 5hwaA-1z6tA:
undetectable		 5hwaA-1z6tA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		3 / 3 VAL A 124
LEU A 306
MET A 301
 None
 0.87A 5ikrA-1z6tA:
undetectable		 5ikrA-1z6tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 5 VAL A 442
THR A 446
VAL A 399
LEU A 415
 None
 0.97A 6bqgA-1z6tA:
3.4		 6bqgA-1z6tA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.24A 6eliA-1z6tA:
undetectable		 6eliA-1z6tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 282
ILE A 136
GLY A 275
ARG A 265
 None
 0.89A 6hd6B-1z6tA:
undetectable		 6hd6B-1z6tA:
9.51