SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		4 / 7 THR A  64
TRP A  66
MET A 110
LEU A  88
 None
 1.34A 2rezA-1z6xA:
0.0		 2rezA-1z6xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.87A 4ax8A-1z6xA:
2.5		 4ax8A-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.89A 4aztA-1z6xA:
undetectable		 4aztA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.87A 4azvA-1z6xA:
undetectable		 4azvA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		3 / 3 ARG A 149
THR A 152
TRP A 153
 None
 1.08A 4d7hA-1z6xA:
undetectable		 4d7hA-1z6xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 ALA A  28
PHE A 124
LEU A  37
LEU A 170
ILE A  89
 GDP  A 201 (-4.1A)
None
None
None
None
 1.03A 4km2A-1z6xA:
undetectable		 4km2A-1z6xA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		4 / 7 VAL A 155
ALA A 125
LEU A 121
ASP A 141
 None
 0.73A 4l9iA-1z6xA:
undetectable		 4l9iA-1z6xA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		3 / 3 ARG A 149
THR A 152
TRP A 153
 None
 1.11A 4ug5A-1z6xA:
0.0		 4ug5A-1z6xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		3 / 3 ARG A 149
THR A 152
TRP A 153
 None
 1.07A 4uglA-1z6xA:
undetectable		 4uglA-1z6xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.93A 4uw0A-1z6xA:
undetectable		 4uw0A-1z6xA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		3 / 3 ARG A 149
THR A 152
TRP A 153
 None
 1.07A 5g6cA-1z6xA:
undetectable		 5g6cA-1z6xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		4 / 4 GLY A  24
LEU A  25
VAL A  68
GLU A 106
 None
 1.21A 5yw0A-1z6xA:
undetectable		 5yw0A-1z6xA:
20.85