SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.93A 1jnoA-1z72A:
undetectable		 1jnoA-1z72A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.93A 1jnoB-1z72A:
undetectable		 1jnoB-1z72A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 136
HIS A 137
VAL A 140
 None
 0.49A 1lqtB-1z72A:
undetectable		 1lqtB-1z72A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 136
HIS A 137
VAL A 140
 None
 0.47A 1lquB-1z72A:
undetectable		 1lquB-1z72A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.92A 1magA-1z72A:
undetectable		 1magA-1z72A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.92A 1magB-1z72A:
undetectable		 1magB-1z72A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.93A 1ng8A-1z72A:
undetectable		 1ng8A-1z72A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 145
VAL A 209
TRP A  25
 ACY  A 801 ( 4.6A)
None
None
 0.93A 1ng8B-1z72A:
undetectable		 1ng8B-1z72A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 6 VAL A 118
THR A 119
LEU A 211
PHE A 215
 None
None
None
ACY  A 801 (-3.6A)
 1.09A 1s8fB-1z72A:
undetectable		 1s8fB-1z72A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 11 LEU A  47
ASP A  49
ILE A 218
GLY A 219
HIS A  31
 None
 1.33A 1s9aA-1z72A:
undetectable		 1s9aA-1z72A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 169
GLY A 153
LEU A 148
PHE A  33
 None
 1.04A 2vctD-1z72A:
undetectable		 2vctD-1z72A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 127
GLY A  66
ALA A  67
MET A  64
 None
 0.87A 2wekB-1z72A:
undetectable		 2wekB-1z72A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 149
GLU A 212
THR A 119
 ACY  A 801 (-3.8A)
ACY  A 801 (-2.7A)
None
 1.04A 2y7hB-1z72A:
undetectable		 2y7hB-1z72A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  18
GLY A  15
VAL A 140
ILE A 144
VAL A 143
 None
 1.02A 4c9lA-1z72A:
undetectable		 4c9lA-1z72A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  18
GLY A  15
VAL A 140
ILE A 144
VAL A 143
 None
 1.00A 4c9lB-1z72A:
undetectable		 4c9lB-1z72A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 GLN A 207
ASN A 206
TRP A 205
ILE A 144
 None
 1.22A 4ii8A-1z72A:
undetectable		 4ii8A-1z72A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ASP A  24
LEU A 148
VAL A 140
 None
 0.52A 4jecB-1z72A:
undetectable		 4jecB-1z72A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  12
VAL A 185
ASP A 186
 None
 0.61A 4y8wC-1z72A:
undetectable		 4y8wC-1z72A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  29
LEU A 148
TYR A   6
LYS A  23
 None
 0.98A 4z69A-1z72A:
undetectable		 4z69A-1z72A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 142
LEU A  85
GLY A  66
ALA A  67
 None
 0.81A 5f1aA-1z72A:
0.4		 5f1aA-1z72A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 6 ILE A 164
TYR A  95
PHE A 100
TRP A 152
 None
 1.37A 5g08A-1z72A:
undetectable		 5g08A-1z72A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 6 GLN A  84
ARG A  80
PHE A  81
PHE A  57
 None
None
None
ACY  A 801 (-3.4A)
 1.32A 5mwyA-1z72A:
undetectable		 5mwyA-1z72A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 5 LEU A  65
PHE A  61
LEU A  88
PHE A  87
 None
 1.05A 5x19C-1z72A:
3.8
5x19J-1z72A:
undetectable		 5x19C-1z72A:
21.56
5x19J-1z72A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 10 TYR A   6
ALA A   7
LEU A 150
ASP A 151
VAL A 181
 None
 1.23A 6g2pB-1z72A:
0.0		 6g2pB-1z72A:
21.05