SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.72A 1yc2E-1z7aA:
undetectable		 1yc2E-1z7aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  41
GLN A  61
PRO A  62
 None
 0.93A 2qhfA-1z7aA:
undetectable		 2qhfA-1z7aA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 259
HIS A 126
TYR A 211
TYR A 189
 None
 1.27A 2vmyA-1z7aA:
undetectable
2vmyB-1z7aA:
undetectable		 2vmyA-1z7aA:
23.10
2vmyB-1z7aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 244
LEU A 243
LEU A 254
LYS A 237
HIS A 282
 None
 1.18A 2x7hA-1z7aA:
0.1
2x7hB-1z7aA:
1.4		 2x7hA-1z7aA:
20.96
2x7hB-1z7aA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 132
ILE A 131
GLN A 140
GLU A 141
 None
 0.92A 2ya7C-1z7aA:
undetectable		 2ya7C-1z7aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 CYH A  42
ARG A  41
SER A  50
ALA A  52
MET A 104
 None
 1.36A 3qt0A-1z7aA:
0.0		 3qt0A-1z7aA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 287
TYR A 278
LEU A  33
 None
 0.74A 3sueB-1z7aA:
undetectable		 3sueB-1z7aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 GLY A  78
GLU A  40
VAL A 102
GLU A  36
TYR A  35
 None
 1.34A 4fgzA-1z7aA:
undetectable		 4fgzA-1z7aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 301
ILE A 293
TRP A  21
LEU A 193
 None
 0.89A 4jq1B-1z7aA:
3.0		 4jq1B-1z7aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 126
LEU A  54
ASN A 216
LEU A 213
GLY A 166
 None
 1.21A 4qckA-1z7aA:
undetectable		 4qckA-1z7aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.72A 4rmjA-1z7aA:
undetectable		 4rmjA-1z7aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 268
PHE A 100
TYR A 211
TYR A  35
LEU A  33
 None
 1.09A 5czyA-1z7aA:
undetectable		 5czyA-1z7aA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 SER A 186
TYR A 211
PHE A 100
HIS A 259
 None
 1.46A 5dlvB-1z7aA:
0.5		 5dlvB-1z7aA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  28
PRO A 210
GLY A 169
LEU A 213
 None
 0.98A 5eslA-1z7aA:
undetectable		 5eslA-1z7aA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 259
HIS A 126
THR A 168
ALA A 106
PHE A  53
 None
 1.26A 5iwuA-1z7aA:
undetectable		 5iwuA-1z7aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 301
HIS A  20
HIS A  18
 None
None
EDO  A 309 (-4.3A)
 0.96A 5oexA-1z7aA:
undetectable		 5oexA-1z7aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  37
ARG A 261
TYR A  75
 None
 0.64A 5trqB-1z7aA:
undetectable		 5trqB-1z7aA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  33
PHE A  31
PHE A  90
LEU A  86
 None
 0.88A 5x1bP-1z7aA:
undetectable		 5x1bP-1z7aA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1z7a CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 259
ASN A  34
LEU A  33
 None
 0.89A 6f7lB-1z7aA:
undetectable		 6f7lB-1z7aA:
19.83