SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 7 ARG A  91
VAL A 173
LEU A  23
LEU A  15
MET A  14
 None
 1.44A 3gp0A-1z7cA:
undetectable		 3gp0A-1z7cA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		4 / 8 TYR A  28
GLU A  33
PHE A  44
SER A  43
 None
 1.04A 3jz0B-1z7cA:
2.3		 3jz0B-1z7cA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		4 / 7 LEU A 117
LEU A 124
VAL A 185
SER A 188
 None
 0.95A 3r9vA-1z7cA:
4.1
3r9vB-1z7cA:
4.2		 3r9vA-1z7cA:
21.50
3r9vB-1z7cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 9 ILE A 121
GLN A 181
LEU A 177
VAL A 173
LEU A 117
 None
 1.24A 4g1bC-1z7cA:
2.7		 4g1bC-1z7cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 11 LEU A  93
LEU A  87
LEU A  23
HIS A 112
LEU A 113
 None
 1.05A 4p65B-1z7cA:
undetectable
4p65D-1z7cA:
undetectable
4p65G-1z7cA:
undetectable
4p65H-1z7cA:
undetectable		 4p65B-1z7cA:
14.74
4p65D-1z7cA:
14.74
4p65G-1z7cA:
8.20
4p65H-1z7cA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		3 / 3 GLU A 174
ARG A 178
GLN A  22
 None
 0.97A 4rtbA-1z7cA:
undetectable		 4rtbA-1z7cA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 10 LEU A  23
ALA A  20
LEU A 114
GLY A 120
HIS A  12
 None
 1.26A 5dx3A-1z7cA:
undetectable		 5dx3A-1z7cA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 11 LEU A  23
ALA A  20
LEU A 114
GLY A 120
HIS A  12
 None
 1.26A 5dxgB-1z7cA:
undetectable		 5dxgB-1z7cA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		5 / 12 ILE A  78
VAL A 185
LEU A 117
HIS A  12
MET A  14
 None
 1.37A 5esgA-1z7cA:
undetectable		 5esgA-1z7cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		3 / 3 VAL A 180
LYS A 172
MET A 170
 None
 1.00A 5nknA-1z7cA:
undetectable		 5nknA-1z7cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		4 / 6 LEU A   6
SER A   7
PHE A  10
ASP A  11
 None
 0.70A 5om3A-1z7cA:
undetectable
5om3B-1z7cA:
undetectable		 5om3A-1z7cA:
18.54
5om3B-1z7cA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		3 / 3 PHE A 176
ASP A 171
LEU A  15
 None
 0.75A 5uhbC-1z7cA:
undetectable		 5uhbC-1z7cA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		3 / 3 PHE A 176
ASP A 171
LEU A  15
 None
 0.77A 5uhcC-1z7cA:
undetectable		 5uhcC-1z7cA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens) 		3 / 3 PHE A 146
ASP A 147
LYS A 158
 None
 0.74A 6awtD-1z7cA:
undetectable		 6awtD-1z7cA:
22.39