SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.73A 1dmaA-1z7eA:
undetectable		 1dmaA-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 6 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.79A 1dmaB-1z7eA:
undetectable		 1dmaB-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.21A 1gwrA-1z7eA:
undetectable		 1gwrA-1z7eA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.21A 1i9gA-1z7eA:
6.4		 1i9gA-1z7eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		3 / 3 THR A 513
LEU A 517
VAL A 520
 None
 0.40A 1mz9E-1z7eA:
undetectable		 1mz9E-1z7eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.26A 1pcgA-1z7eA:
undetectable		 1pcgA-1z7eA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.26A 1pcgB-1z7eA:
undetectable		 1pcgB-1z7eA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 544
TRP A 632
LEU A 630
TRP A 493
 None
 1.37A 1q0yH-1z7eA:
undetectable
1q0yL-1z7eA:
undetectable		 1q0yH-1z7eA:
14.52
1q0yL-1z7eA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 ILE A  88
ALA A   7
PHE A  82
LEU A  19
ILE A  29
 None
 1.29A 1uduA-1z7eA:
undetectable		 1uduA-1z7eA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 6 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhA-1z7eA:
undetectable		 1uwhA-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 6 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1z7eA:
undetectable		 1uwhB-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 GLU A 521
GLY A 507
ILE A 516
LEU A 501
ALA A 503
 None
 0.96A 1x7pA-1z7eA:
undetectable
1x7pB-1z7eA:
2.4		 1x7pA-1z7eA:
19.27
1x7pB-1z7eA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 ILE A 185
MET A   1
ALA A  96
ARG A 134
PHE A 101
 None
 1.26A 2noaA-1z7eA:
2.7		 2noaA-1z7eA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 ARG A 138
ILE A 144
HIS A 133
GLY A 113
VAL A 136
 None
 1.46A 2nyrB-1z7eA:
6.0		 2nyrB-1z7eA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.34A 2ocfA-1z7eA:
undetectable		 2ocfA-1z7eA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.36A 2rhmB-1z7eA:
3.3		 2rhmB-1z7eA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.25A 2rhmD-1z7eA:
2.8		 2rhmD-1z7eA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 8 ALA A 281
LEU A 296
LEU A 298
ILE A 276
VAL A 259
 None
 1.40A 2uxpA-1z7eA:
1.4		 2uxpA-1z7eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 ILE A 185
MET A   1
ARG A 134
ALA A 100
PHE A 101
 None
 1.24A 2vppA-1z7eA:
1.9		 2vppA-1z7eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		6 / 11 ILE A  88
ALA A 100
LEU A  95
ILE A  92
SER A  27
PHE A   6
 None
 1.43A 2w9sA-1z7eA:
undetectable		 2w9sA-1z7eA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		6 / 11 ILE A  88
ALA A 100
LEU A  95
ILE A  92
SER A  27
PHE A   6
 None
 1.44A 2w9sB-1z7eA:
undetectable		 2w9sB-1z7eA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 4 ARG A 138
GLY A 142
GLU A 192
SER A  81
 None
 1.22A 2xctS-1z7eA:
1.9
2xctU-1z7eA:
2.2		 2xctS-1z7eA:
23.36
2xctU-1z7eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 GLY A  43
HIS A 162
HIS A 163
CYH A 166
 None
 1.05A 3ai8A-1z7eA:
undetectable		 3ai8A-1z7eA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 6 GLY A  43
HIS A 162
HIS A 163
CYH A 166
 None
 1.06A 3ai8B-1z7eA:
undetectable		 3ai8B-1z7eA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 4 VAL A 343
ARG A 334
ILE A 327
THR A 316
 None
None
ATP  A1001 (-4.1A)
None
 1.25A 3cl9A-1z7eA:
undetectable		 3cl9A-1z7eA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 PRO A 459
ILE A 462
PRO A 402
TYR A 398
 None
None
None
UGA  A1101 (-4.5A)
 1.21A 3d9lA-1z7eA:
undetectable
3d9lY-1z7eA:
undetectable		 3d9lA-1z7eA:
12.76
3d9lY-1z7eA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 387
ASP A 347
ILE A 353
VAL A 318
ILE A 320
 None
ATP  A1001 (-2.3A)
None
None
None
 0.96A 3em3B-1z7eA:
undetectable		 3em3B-1z7eA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 9 ASP A 368
GLY A 322
LEU A 389
VAL A 380
ILE A 376
 ATP  A1001 (-3.3A)
ATP  A1001 ( 3.9A)
None
None
None
 1.02A 3em4B-1z7eA:
undetectable		 3em4B-1z7eA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 ASP A 368
GLY A 322
LEU A 389
VAL A 380
ILE A 376
 ATP  A1001 (-3.3A)
ATP  A1001 ( 3.9A)
None
None
None
 0.84A 3em4U-1z7eA:
undetectable		 3em4U-1z7eA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 ASP A 368
GLY A 322
LEU A 389
VAL A 380
ILE A 376
 ATP  A1001 (-3.3A)
ATP  A1001 ( 3.9A)
None
None
None
 1.06A 3em4V-1z7eA:
undetectable		 3em4V-1z7eA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 GLY A 328
GLY A 322
GLY A 349
LEU A 387
ILE A 327
 None
ATP  A1001 ( 3.9A)
ATP  A1001 ( 4.8A)
None
ATP  A1001 (-4.1A)
 0.98A 3embA-1z7eA:
6.5		 3embA-1z7eA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.18A 3erdA-1z7eA:
undetectable		 3erdA-1z7eA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		3 / 3 ARG A 505
THR A 645
THR A 394
 None
 0.73A 3k2hB-1z7eA:
2.1		 3k2hB-1z7eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.29A 3olsB-1z7eA:
undetectable		 3olsB-1z7eA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.25A 3uudA-1z7eA:
undetectable		 3uudA-1z7eA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.14A 3vywA-1z7eA:
4.1		 3vywA-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.14A 3vywB-1z7eA:
4.9		 3vywB-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.11A 3vywC-1z7eA:
4.5		 3vywC-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.11A 3vywD-1z7eA:
5.1		 3vywD-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.87A 4hyfA-1z7eA:
undetectable		 4hyfA-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.90A 4hyfB-1z7eA:
undetectable		 4hyfB-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.86A 4hyfC-1z7eA:
undetectable		 4hyfC-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 ASN A 324
ALA A 352
SER A 350
ARG A 355
 None
 1.22A 4ijiF-1z7eA:
undetectable		 4ijiF-1z7eA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		6 / 12 GLY A 322
ASP A 347
ILE A 348
ASP A 368
ILE A 369
LEU A 408
 ATP  A1001 ( 3.9A)
ATP  A1001 (-2.3A)
ATP  A1001 (-4.5A)
ATP  A1001 (-3.3A)
ATP  A1001 (-4.3A)
ATP  A1001 ( 4.9A)
 0.89A 4iv8A-1z7eA:
6.0		 4iv8A-1z7eA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		6 / 12 GLY A 322
ASP A 347
ILE A 348
ASP A 368
ILE A 369
LEU A 408
 ATP  A1001 ( 3.9A)
ATP  A1001 (-2.3A)
ATP  A1001 (-4.5A)
ATP  A1001 (-3.3A)
ATP  A1001 (-4.3A)
ATP  A1001 ( 4.9A)
 0.89A 4iv8B-1z7eA:
6.1		 4iv8B-1z7eA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 ARG A 489
ASP A 471
GLU A 434
VAL A 405
 None
None
UGA  A1101 (-4.0A)
None
 1.45A 4nkvB-1z7eA:
undetectable		 4nkvB-1z7eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.24A 4zn7B-1z7eA:
undetectable		 4zn7B-1z7eA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.78A 5a06A-1z7eA:
7.9		 5a06A-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.77A 5a06B-1z7eA:
8.1		 5a06B-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.78A 5a06C-1z7eA:
8.1		 5a06C-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.77A 5a06E-1z7eA:
8.2		 5a06E-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.79A 5a06F-1z7eA:
8.0		 5a06F-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 LEU A 470
GLN A 468
PHE A 410
LEU A 414
 None
 0.99A 5b3sC-1z7eA:
2.5
5b3sJ-1z7eA:
undetectable		 5b3sC-1z7eA:
15.15
5b3sJ-1z7eA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 LEU A 470
GLN A 468
PHE A 410
LEU A 414
 None
 0.98A 5b3sP-1z7eA:
2.5		 5b3sP-1z7eA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.25A 5dxbA-1z7eA:
undetectable		 5dxbA-1z7eA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.30A 5dxeB-1z7eA:
undetectable		 5dxeB-1z7eA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 8 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1z7eA:
undetectable		 5hi2A-1z7eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 GLY A 555
PHE A 488
ASP A 559
PHE A 485
 None
 0.91A 5hieD-1z7eA:
undetectable		 5hieD-1z7eA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.22A 5hyrA-1z7eA:
undetectable		 5hyrA-1z7eA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 LEU A 470
GLN A 468
PHE A 410
LEU A 414
 None
 0.97A 5iy5C-1z7eA:
2.5
5iy5J-1z7eA:
undetectable		 5iy5C-1z7eA:
15.15
5iy5J-1z7eA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 9 LEU A 103
LEU A 108
ILE A 152
THR A 128
LEU A 117
 None
 1.46A 5ljdA-1z7eA:
0.0		 5ljdA-1z7eA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 6 THR A 538
ASN A 567
ILE A 623
GLU A 633
 None
 1.01A 5uigA-1z7eA:
undetectable		 5uigA-1z7eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 LEU A 331
VAL A 323
LEU A 336
ILE A 353
 None
 1.03A 5v0vA-1z7eA:
undetectable		 5v0vA-1z7eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A 165
ALA A 169
LEU A 172
LEU A  14
 None
 0.85A 5vkqA-1z7eA:
2.1
5vkqD-1z7eA:
undetectable		 5vkqA-1z7eA:
17.19
5vkqD-1z7eA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A  14
LEU A 165
ALA A 169
LEU A 172
 None
 0.85A 5vkqA-1z7eA:
2.1
5vkqB-1z7eA:
undetectable		 5vkqA-1z7eA:
17.19
5vkqB-1z7eA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A  14
LEU A 165
ALA A 169
LEU A 172
 None
 0.79A 5vkqB-1z7eA:
undetectable
5vkqC-1z7eA:
2.2		 5vkqB-1z7eA:
17.19
5vkqC-1z7eA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 LEU A 470
GLN A 468
PHE A 410
LEU A 414
 None
 0.94A 5zcoC-1z7eA:
2.3
5zcoJ-1z7eA:
undetectable		 5zcoC-1z7eA:
15.15
5zcoJ-1z7eA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ALA A 393
ILE A 512
LEU A 498
ILE A 528
 ATP  A1001 ( 3.6A)
None
None
UGA  A1101 (-3.5A)
 0.88A 6b5vA-1z7eA:
undetectable
6b5vB-1z7eA:
undetectable		 6b5vA-1z7eA:
7.16
6b5vB-1z7eA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 6 THR A 486
ARG A 426
PRO A 430
ILE A 550
 None
 1.41A 6ef6A-1z7eA:
0.0		 6ef6A-1z7eA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 9 ILE A 551
ILE A 550
GLU A 342
VAL A 385
ILE A 428
 None
 1.48A 6hloA-1z7eA:
4.3		 6hloA-1z7eA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 ILE A 525
TYR A 608
GLY A 507
SER A 509
ALA A 511
 None
UGA  A1101 ( 4.6A)
None
None
UGA  A1101 (-3.3A)
 1.18A 6ieyA-1z7eA:
3.7
6ieyB-1z7eA:
3.5		 6ieyA-1z7eA:
18.61
6ieyB-1z7eA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 TRP A 632
ARG A 541
ASP A 539
GLU A 640
 None
 0.98A 6mn4A-1z7eA:
1.3		 6mn4A-1z7eA:
18.21