SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		5 / 12 PRO A 638
ILE A 875
GLN A 646
ALA A 648
SER A 866
 None
None
TBR  A 999 (-3.1A)
None
None
 1.36A 1fm4A-1z7lA:
0.0		 1fm4A-1z7lA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		4 / 7 ARG A 880
VAL A 863
ASN A 856
ASP A 854
 None
 1.34A 1hwiC-1z7lA:
undetectable		 1hwiC-1z7lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		4 / 7 ARG A 880
VAL A 863
ASN A 856
ASP A 854
 None
 1.34A 1hwiD-1z7lA:
undetectable		 1hwiD-1z7lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		5 / 12 PRO A 638
ILE A 875
GLN A 646
ALA A 648
SER A 866
 None
None
TBR  A 999 (-3.1A)
None
None
 1.13A 4a83A-1z7lA:
undetectable		 4a83A-1z7lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		3 / 3 ALA A 864
ASN A 867
LEU A 868
 None
 0.51A 5i1nC-1z7lA:
undetectable		 5i1nC-1z7lA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1
(Mus
musculus) 		4 / 5 PHE A 861
PHE A 857
LEU A 771
LEU A 762
 None
 1.28A 5veuH-1z7lA:
undetectable		 5veuH-1z7lA:
20.67