SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 6 PHE A  57
PHE A  59
GLY A 106
GLY A 107
 None
 0.88A 2qr2A-1z81A:
undetectable
2qr2B-1z81A:
undetectable		 2qr2A-1z81A:
20.16
2qr2B-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 6 PHE A  59
PHE A  73
GLY A 106
GLY A 107
 None
 0.91A 2qr2A-1z81A:
undetectable
2qr2B-1z81A:
undetectable		 2qr2A-1z81A:
20.16
2qr2B-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 5 GLY A 106
GLY A 107
PHE A  57
PHE A  59
 None
 0.83A 2qr2A-1z81A:
undetectable
2qr2B-1z81A:
undetectable		 2qr2A-1z81A:
20.16
2qr2B-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 5 GLY A 106
GLY A 107
PHE A  59
PHE A  73
 None
 0.87A 2qr2A-1z81A:
undetectable
2qr2B-1z81A:
undetectable		 2qr2A-1z81A:
20.16
2qr2B-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 6 PHE A  59
PHE A  73
GLY A 106
GLY A 107
 None
 0.82A 2qx6A-1z81A:
undetectable
2qx6B-1z81A:
undetectable		 2qx6A-1z81A:
20.16
2qx6B-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		3 / 3 SER A 117
GLY A 151
SER A 145
 None
 0.62A 3loqA-1z81A:
undetectable		 3loqA-1z81A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 11 PHE A  59
PHE A  73
GLY A 106
GLY A 107
ILE A  94
 None
 1.08A 3owxA-1z81A:
undetectable
3owxB-1z81A:
undetectable		 3owxA-1z81A:
20.49
3owxB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 9 GLY A 106
GLY A 107
PHE A  57
ILE A  47
PHE A  59
 None
 0.99A 4fgjA-1z81A:
undetectable
4fgjB-1z81A:
undetectable		 4fgjA-1z81A:
20.49
4fgjB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 12 GLY A 106
GLY A 107
ILE A  94
PHE A  59
PHE A  73
 None
 1.03A 4fglA-1z81A:
undetectable
4fglB-1z81A:
undetectable		 4fglA-1z81A:
20.49
4fglB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 11 PHE A  57
ILE A  47
PHE A  59
GLY A 106
GLY A 107
 None
 1.05A 4fglA-1z81A:
undetectable
4fglB-1z81A:
undetectable		 4fglA-1z81A:
20.49
4fglB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		4 / 8 PHE A  59
PHE A  73
GLY A 106
ILE A  94
 None
 0.96A 4qoiA-1z81A:
undetectable
4qoiB-1z81A:
undetectable		 4qoiA-1z81A:
20.49
4qoiB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 11 GLY A 106
GLY A 107
ILE A  94
PHE A  59
PHE A  73
 None
 1.06A 4qoiA-1z81A:
undetectable
4qoiB-1z81A:
undetectable		 4qoiA-1z81A:
20.49
4qoiB-1z81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 12 GLY A 106
GLY A 107
ILE A  94
PHE A  59
PHE A  73
 None
 0.90A 4zvmA-1z81A:
undetectable
4zvmB-1z81A:
undetectable		 4zvmA-1z81A:
20.16
4zvmB-1z81A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1z81 CYCLOPHILIN
(Plasmodium
yoelii) 		5 / 11 PHE A  59
PHE A  73
GLY A 106
GLY A 107
ILE A  94
 None
 1.03A 4zvmA-1z81A:
undetectable
4zvmB-1z81A:
undetectable		 4zvmA-1z81A:
20.16
4zvmB-1z81A:
20.16