SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 LEU A 362
ALA A 588
GLY A 582
ILE A 416
 None
 0.66A 1d4yB-1z8lA:
undetectable		 1d4yB-1z8lA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 GLN A 389
HIS A  82
PRO A  81
 None
 0.95A 1d8cA-1z8lA:
2.7		 1d8cA-1z8lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 10 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.94A 1hsgA-1z8lA:
undetectable		 1hsgA-1z8lA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 HIS A 573
TYR A 572
SER A 390
GLU A 457
 None
 1.01A 1i7zA-1z8lA:
undetectable		 1i7zA-1z8lA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLU A 425
HIS A 553
HIS A 377
ASN A 519
ASP A 453
 ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
ZN  A1751 (-3.3A)
ZN  A1751 (-3.7A)
ZN  A1751 (-2.0A)
 1.48A 1ituA-1z8lA:
undetectable		 1ituA-1z8lA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 5 GLU A 425
ARG A 534
ASP A 465
THR A 538
 ZN  A1752 (-2.5A)
None
None
None
 0.98A 1k4tA-1z8lA:
0.0		 1k4tA-1z8lA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A  62
PRO A 412
GLY A 581
ILE A 398
LEU A 105
 None
 1.11A 1kglA-1z8lA:
undetectable		 1kglA-1z8lA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 ILE A 456
GLY A 385
VAL A 562
GLY A 391
HIS A 377
 None
None
None
None
ZN  A1751 (-3.3A)
 1.15A 1kiaB-1z8lA:
undetectable		 1kiaB-1z8lA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 374
GLY A 581
VAL A 584
LEU A 477
LEU A 462
 None
 1.27A 1mx1E-1z8lA:
2.4		 1mx1E-1z8lA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 THR A 461
GLU A 457
ASP A 387
 None
None
ZN  A1751 ( 2.6A)
 0.80A 1nt2A-1z8lA:
undetectable		 1nt2A-1z8lA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 5 GLU A 425
ARG A 534
ASP A 465
THR A 538
 ZN  A1752 (-2.5A)
None
None
None
 1.06A 1rr8C-1z8lA:
0.0		 1rr8C-1z8lA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 5 GLU A 425
ARG A 534
ASP A 465
THR A 538
 ZN  A1752 (-2.5A)
None
None
None
 1.03A 1rrjA-1z8lA:
0.0		 1rrjA-1z8lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 10 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.92A 1sdvA-1z8lA:
undetectable		 1sdvA-1z8lA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 4 THR A 738
GLY A 707
ASP A 710
ALA A 693
 None
 1.17A 1sg9A-1z8lA:
undetectable		 1sg9A-1z8lA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 ARG A 363
ARG A 411
ILE A 416
 None
 0.78A 1uobA-1z8lA:
undetectable		 1uobA-1z8lA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 1v54A-1z8lA:
undetectable
1v54C-1z8lA:
2.5		 1v54A-1z8lA:
20.42
1v54C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 1v54N-1z8lA:
undetectable
1v54P-1z8lA:
2.5		 1v54N-1z8lA:
20.42
1v54P-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.35A 1v55A-1z8lA:
undetectable
1v55C-1z8lA:
2.5		 1v55A-1z8lA:
20.42
1v55C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 GLY A 391
ALA A 393
SER A 390
TYR A 559
HIS A 573
 None
 1.24A 1y7iA-1z8lA:
2.5		 1y7iA-1z8lA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 6 TYR A 299
GLY A 548
PHE A 546
SER A 547
 None
 1.23A 2a3cA-1z8lA:
2.1		 2a3cA-1z8lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 6 TYR A 299
GLY A 548
PHE A 546
SER A 547
 None
 1.19A 2a3cB-1z8lA:
2.1		 2a3cB-1z8lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 10 TYR A 612
ILE A 614
ILE A 732
PRO A 706
ILE A 708
 None
 1.38A 2dm6A-1z8lA:
2.3
2dm6B-1z8lA:
undetectable		 2dm6A-1z8lA:
19.08
2dm6B-1z8lA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 2dyrA-1z8lA:
undetectable
2dyrC-1z8lA:
2.5		 2dyrA-1z8lA:
20.42
2dyrC-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 2dyrN-1z8lA:
undetectable
2dyrP-1z8lA:
2.4		 2dyrN-1z8lA:
20.42
2dyrP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 2eijA-1z8lA:
3.2
2eijC-1z8lA:
2.5		 2eijA-1z8lA:
20.42
2eijC-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 2eijN-1z8lA:
2.3
2eijP-1z8lA:
2.5		 2eijN-1z8lA:
20.42
2eijP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 2eikA-1z8lA:
undetectable
2eikC-1z8lA:
2.5		 2eikA-1z8lA:
20.42
2eikC-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.35A 2eikN-1z8lA:
2.2
2eikP-1z8lA:
2.5		 2eikN-1z8lA:
20.42
2eikP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.31A 2eilA-1z8lA:
undetectable
2eilC-1z8lA:
2.5		 2eilA-1z8lA:
20.42
2eilC-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 2eilN-1z8lA:
undetectable
2eilP-1z8lA:
2.5		 2eilN-1z8lA:
20.42
2eilP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 TYR A 176
ARG A 204
PHE A 185
VAL A 329
 None
 0.99A 2fl5E-1z8lA:
undetectable
2fl5F-1z8lA:
undetectable		 2fl5E-1z8lA:
14.35
2fl5F-1z8lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.83A 2nmzA-1z8lA:
undetectable		 2nmzA-1z8lA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.85A 2nmzB-1z8lA:
undetectable		 2nmzB-1z8lA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 GLY A 533
ILE A 373
VAL A 584
ILE A 398
VAL A 399
 None
 1.11A 2nnhB-1z8lA:
undetectable		 2nnhB-1z8lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 265
ALA A 435
LEU A 268
VAL A 287
LEU A 259
 None
 1.00A 2nyuA-1z8lA:
undetectable		 2nyuA-1z8lA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 SER A 615
HIS A 697
ASP A 683
 None
 0.80A 2oxtA-1z8lA:
undetectable		 2oxtA-1z8lA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 MET A  58
LEU A 473
LEU A 477
LEU A 481
LEU A 574
 None
 1.13A 2pnjA-1z8lA:
undetectable		 2pnjA-1z8lA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 ARG A 204
SER A 322
TYR A 228
 None
 0.97A 2q2hA-1z8lA:
undetectable
2q2hB-1z8lA:
undetectable		 2q2hA-1z8lA:
11.17
2q2hB-1z8lA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.94A 2q64A-1z8lA:
undetectable		 2q64A-1z8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.32A 2y69A-1z8lA:
undetectable
2y69C-1z8lA:
2.5		 2y69A-1z8lA:
20.42
2y69C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 10 ILE A 292
GLY A 224
GLY A 168
PRO A 290
ILE A 346
 None
 1.37A 2y7wB-1z8lA:
undetectable		 2y7wB-1z8lA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 3abkA-1z8lA:
2.8
3abkC-1z8lA:
2.5		 3abkA-1z8lA:
20.42
3abkC-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.32A 3abkN-1z8lA:
undetectable
3abkP-1z8lA:
2.5		 3abkN-1z8lA:
20.42
3abkP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 3abmN-1z8lA:
2.2
3abmP-1z8lA:
2.5		 3abmN-1z8lA:
20.42
3abmP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.32A 3ag2A-1z8lA:
2.2
3ag2C-1z8lA:
2.5		 3ag2A-1z8lA:
20.42
3ag2C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 3ag2N-1z8lA:
undetectable
3ag2P-1z8lA:
2.5		 3ag2N-1z8lA:
20.42
3ag2P-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.35A 3ag3A-1z8lA:
2.6
3ag3C-1z8lA:
2.5		 3ag3A-1z8lA:
20.42
3ag3C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.31A 3ag3N-1z8lA:
2.5
3ag3P-1z8lA:
2.5		 3ag3N-1z8lA:
20.42
3ag3P-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.34A 3ag4A-1z8lA:
undetectable
3ag4C-1z8lA:
2.5		 3ag4A-1z8lA:
20.42
3ag4C-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.35A 3ag4N-1z8lA:
undetectable
3ag4P-1z8lA:
3.0		 3ag4N-1z8lA:
20.42
3ag4P-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.96A 3d1xB-1z8lA:
undetectable		 3d1xB-1z8lA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 288
ASN A 260
ASN A 262
ILE A 283
GLY A 282
 None
 1.17A 3eeyA-1z8lA:
2.2		 3eeyA-1z8lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 288
ASN A 260
ASN A 262
ILE A 283
GLY A 282
 None
 1.17A 3eeyB-1z8lA:
undetectable		 3eeyB-1z8lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 288
ASN A 260
ASN A 262
ILE A 283
GLY A 282
 None
 1.16A 3eeyH-1z8lA:
undetectable		 3eeyH-1z8lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 288
ASN A 260
ASN A 262
ILE A 283
GLY A 282
 None
 1.15A 3eeyI-1z8lA:
undetectable		 3eeyI-1z8lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.98A 3em6B-1z8lA:
undetectable		 3em6B-1z8lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 GLY A 282
PRO A 267
LEU A 289
 None
 0.53A 3hcpB-1z8lA:
2.3		 3hcpB-1z8lA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 TYR A 692
HIS A 689
LEU A 671
LEU A 632
PHE A 639
 None
 1.24A 3jwqA-1z8lA:
2.7		 3jwqA-1z8lA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		6 / 11 TYR A 692
HIS A 689
LEU A 671
LEU A 632
PHE A 639
THR A 745
 None
 1.47A 3jwqB-1z8lA:
2.7
3jwqC-1z8lA:
undetectable		 3jwqB-1z8lA:
18.08
3jwqC-1z8lA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 11 TYR A 692
HIS A 689
LEU A 671
LEU A 632
PHE A 639
 None
 1.31A 3jwqA-1z8lA:
3.0
3jwqD-1z8lA:
3.0		 3jwqA-1z8lA:
18.08
3jwqD-1z8lA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.84A 3k4vA-1z8lA:
undetectable		 3k4vA-1z8lA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 ASP A 714
SER A 717
LEU A 188
ASP A 184
 None
 1.00A 3m0wE-1z8lA:
undetectable
3m0wF-1z8lA:
undetectable
3m0wG-1z8lA:
undetectable
3m0wH-1z8lA:
undetectable		 3m0wE-1z8lA:
9.25
3m0wF-1z8lA:
9.25
3m0wG-1z8lA:
9.25
3m0wH-1z8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.83A 3ndtA-1z8lA:
undetectable		 3ndtA-1z8lA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.88A 3ndtB-1z8lA:
undetectable		 3ndtB-1z8lA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 LEU A 323
ARG A 204
ALA A 203
GLY A 250
 None
 0.92A 3ny4A-1z8lA:
undetectable		 3ny4A-1z8lA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 10 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 1.00A 3oxwB-1z8lA:
undetectable		 3oxwB-1z8lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 11 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.94A 3oxxD-1z8lA:
undetectable		 3oxxD-1z8lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 ASP A 230
GLY A 321
TYR A 179
GLN A 254
 None
 0.98A 3s3mA-1z8lA:
undetectable		 3s3mA-1z8lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 ASP A 230
GLY A 321
TYR A 179
GLN A 254
 None
 0.99A 3s3nA-1z8lA:
undetectable		 3s3nA-1z8lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 PHE A 144
PRO A 160
GLY A 251
SER A 142
 None
 1.10A 3tzfB-1z8lA:
undetectable		 3tzfB-1z8lA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 6 HIS A 689
GLU A 672
SER A 532
PRO A 468
 None
 1.38A 4apjA-1z8lA:
2.5
4apjP-1z8lA:
undetectable		 4apjA-1z8lA:
21.40
4apjP-1z8lA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.42A 4iclA-1z8lA:
0.7		 4iclA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.43A 4id5A-1z8lA:
0.8		 4id5A-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.47A 4idkA-1z8lA:
1.3		 4idkA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.45A 4ifvA-1z8lA:
0.8		 4ifvA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.44A 4ifyA-1z8lA:
0.8		 4ifyA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 ALA A 423
LEU A 117
TYR A 119
TRP A 421
 None
 0.84A 4iomA-1z8lA:
3.9		 4iomA-1z8lA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 ALA A 423
LEU A 117
TYR A 119
TRP A 421
 None
 0.88A 4jjkA-1z8lA:
undetectable		 4jjkA-1z8lA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 ARG A 527
TRP A 421
PHE A 524
GLU A 424
 None
None
None
ZN  A1751 (-3.6A)
 1.43A 4jseA-1z8lA:
0.6
4jseB-1z8lA:
3.0		 4jseA-1z8lA:
20.85
4jseB-1z8lA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 421
PHE A 524
GLU A 424
ARG A 527
 None
None
ZN  A1751 (-3.6A)
None
 1.41A 4jseA-1z8lA:
0.6
4jseB-1z8lA:
3.0		 4jseA-1z8lA:
20.85
4jseB-1z8lA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.48A 4kfbA-1z8lA:
0.9		 4kfbA-1z8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLN A 254
SER A 162
LEU A 227
PRO A 290
ILE A 258
 None
 1.47A 4kmuC-1z8lA:
0.0		 4kmuC-1z8lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 4 HIS A  82
GLU A 425
HIS A 553
LEU A 551
 None
ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
None
 1.36A 4m2rA-1z8lA:
undetectable		 4m2rA-1z8lA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 SER A 483
SER A 496
TYR A 537
GLU A 486
 None
None
None
NAG  A1757 (-2.7A)
 1.20A 4ms4A-1z8lA:
3.4		 4ms4A-1z8lA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A  83
GLY A 430
ALA A  84
GLY A 376
ASP A 520
 None
 1.15A 4n09A-1z8lA:
undetectable		 4n09A-1z8lA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 430
ALA A  84
LEU A 117
GLY A 376
ASP A 520
 None
 0.91A 4n09C-1z8lA:
undetectable		 4n09C-1z8lA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 11 LEU A 362
ALA A 588
ILE A 450
GLY A 581
ILE A 416
 None
 0.88A 4njtC-1z8lA:
undetectable		 4njtC-1z8lA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 11 LEU A 362
ALA A 588
ILE A 450
GLY A 582
ILE A 416
 None
 0.91A 4njtC-1z8lA:
undetectable		 4njtC-1z8lA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 6 GLU A 457
ASP A 387
GLU A 424
ARG A 210
 None
ZN  A1751 ( 2.6A)
ZN  A1751 (-3.6A)
None
 1.09A 4ntxA-1z8lA:
0.0
4ntxC-1z8lA:
0.0		 4ntxA-1z8lA:
18.99
4ntxC-1z8lA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 6 ILE A 373
GLY A 375
ILE A 359
LEU A 442
 None
 0.75A 4o8fB-1z8lA:
undetectable		 4o8fB-1z8lA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 11 HIS A 377
ASP A 387
GLU A 424
GLU A 425
HIS A 553
 ZN  A1751 (-3.3A)
ZN  A1751 ( 2.6A)
ZN  A1751 (-3.6A)
ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
 0.35A 4pqaA-1z8lA:
19.1		 4pqaA-1z8lA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 259
GLU A 436
ASP A 266
TYR A 687
GLY A 263
 None
 1.28A 4qb9E-1z8lA:
undetectable		 4qb9E-1z8lA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 5b1aN-1z8lA:
3.2
5b1aP-1z8lA:
2.5		 5b1aN-1z8lA:
20.42
5b1aP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.35A 5b1bN-1z8lA:
undetectable
5b1bP-1z8lA:
2.5		 5b1bN-1z8lA:
20.42
5b1bP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 5b3sN-1z8lA:
2.1
5b3sP-1z8lA:
2.5		 5b3sN-1z8lA:
20.42
5b3sP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		3 / 3 ASP A 465
GLU A 457
SER A 704
 None
 0.86A 5bw4B-1z8lA:
undetectable		 5bw4B-1z8lA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 LEU A 405
ILE A 416
GLY A 582
LEU A  65
 None
 0.89A 5eseA-1z8lA:
undetectable		 5eseA-1z8lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.38A 5iy5A-1z8lA:
undetectable
5iy5C-1z8lA:
2.5		 5iy5A-1z8lA:
20.42
5iy5C-1z8lA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLY A 430
ALA A  84
LEU A 117
GLY A 376
ASP A 520
 None
 0.85A 5kb5A-1z8lA:
undetectable		 5kb5A-1z8lA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 265
LEU A 268
ALA A 286
PHE A 164
 None
 1.18A 5kc4E-1z8lA:
undetectable		 5kc4E-1z8lA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 ASN A 451
ARG A 580
ILE A 450
GLY A 581
 None
 0.99A 5nzyA-1z8lA:
undetectable		 5nzyA-1z8lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 GLU A 522
ASN A 519
ASP A 520
GLY A 427
PHE A 209
 None
ZN  A1751 (-3.7A)
None
None
None
 1.12A 5vooF-1z8lA:
undetectable		 5vooF-1z8lA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.32A 5x1fN-1z8lA:
2.2
5x1fP-1z8lA:
2.5		 5x1fN-1z8lA:
20.42
5x1fP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.37A 5zcqN-1z8lA:
2.4
5zcqP-1z8lA:
2.5		 5zcqN-1z8lA:
20.42
5zcqP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 4 ARG A 534
SER A 454
ASP A 387
HIS A 553
 None
None
ZN  A1751 ( 2.6A)
ZN  A1752 (-3.3A)
 1.09A 5zhmA-1z8lA:
0.6		 5zhmA-1z8lA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 8 ILE A 292
GLN A 218
PRO A 290
ALA A 203
TYR A 205
 None
 1.46A 6cduD-1z8lA:
3.3
6cduE-1z8lA:
1.7		 6cduD-1z8lA:
20.58
6cduE-1z8lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 SER A 431
ASN A 260
ASN A 257
ASP A 520
GLY A 518
 None
 1.20A 6dwnA-1z8lA:
undetectable		 6dwnA-1z8lA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 12 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.44A 6eliA-1z8lA:
undetectable		 6eliA-1z8lA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 LEU A 462
PRO A 510
VAL A 464
SER A 472
ILE A 512
 None
None
None
NAG  A1758 (-3.0A)
None
 0.98A 6fdyU-1z8lA:
undetectable		 6fdyU-1z8lA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 8 ASP A 230
TYR A 327
GLY A 310
VAL A 175
 None
 1.08A 6giqL-1z8lA:
1.2
6giqP-1z8lA:
undetectable
6giqT-1z8lA:
undetectable		 6giqL-1z8lA:
21.54
6giqP-1z8lA:
15.13
6giqT-1z8lA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 THR A 558
GLY A 384
TYR A 151
HIS A  82
GLU A 145
 None
 1.23A 6gnfA-1z8lA:
3.0		 6gnfA-1z8lA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		5 / 9 THR A 558
GLY A 385
GLY A 384
TYR A 151
HIS A  82
 None
 1.25A 6gnfA-1z8lA:
3.0		 6gnfA-1z8lA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		6 / 11 ASP A 485
SER A 496
TYR A 537
VAL A 576
ALA A 448
VAL A 464
 None
 1.36A 6hu9A-1z8lA:
4.6
6hu9E-1z8lA:
undetectable
6hu9I-1z8lA:
undetectable		 6hu9A-1z8lA:
22.45
6hu9E-1z8lA:
14.41
6hu9I-1z8lA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		6 / 10 ASP A 485
SER A 496
TYR A 537
VAL A 576
ALA A 448
VAL A 464
 None
 1.36A 6hu9L-1z8lA:
undetectable
6hu9P-1z8lA:
undetectable
6hu9T-1z8lA:
undetectable		 6hu9L-1z8lA:
22.45
6hu9P-1z8lA:
14.41
6hu9T-1z8lA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.30A 6nmfN-1z8lA:
undetectable
6nmfP-1z8lA:
2.7		 6nmfN-1z8lA:
20.42
6nmfP-1z8lA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens) 		4 / 7 TRP A 434
ASP A 106
THR A 361
TRP A 421
 None
 1.33A 6nmpN-1z8lA:
2.6
6nmpP-1z8lA:
undetectable		 6nmpN-1z8lA:
20.42
6nmpP-1z8lA:
15.75