SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 MET A 187
PRO A  18
VAL A  67
GLY A  68
 None
 1.02A 1hrkB-1z8wA:
4.8		 1hrkB-1z8wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 115
PRO A  61
VAL A  36
MET A   1
 None
 1.13A 2qd2A-1z8wA:
4.7		 2qd2A-1z8wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 PHE A   8
ILE A 200
LEU A 148
ILE A  29
GLY A   7
 None
 1.14A 2v0mA-1z8wA:
undetectable		 2v0mA-1z8wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 103
ASN A 143
TYR A 111
LEU A 148
TYR A 144
 None
 1.48A 2ze2A-1z8wA:
0.5		 2ze2A-1z8wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 ASN A 143
SER A 142
ALA A 137
HIS A 166
 None
 1.04A 3aruA-1z8wA:
undetectable		 3aruA-1z8wA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 200
ILE A  65
GLY A   7
TYR A 189
PRO A  18
 None
 1.27A 3elzC-1z8wA:
undetectable		 3elzC-1z8wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 VAL A  67
LEU A 139
ILE A 192
ILE A 165
 None
 0.92A 3gcsA-1z8wA:
undetectable		 3gcsA-1z8wA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		6 / 12 ALA A  23
ILE A 200
GLU A 201
LEU A   4
VAL A  36
ILE A  31
 None
 1.27A 4aztA-1z8wA:
undetectable		 4aztA-1z8wA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLU A  58
ILE A  59
LEU A  52
GLY A  38
PHE A  37
 None
 1.37A 4foxF-1z8wA:
0.0		 4foxF-1z8wA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 ALA A  82
ILE A 103
LEU A 148
ASN A 143
 None
 1.18A 4g19A-1z8wA:
undetectable		 4g19A-1z8wA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 PRO A  61
SER A 162
HIS A  66
SER A 149
 None
 1.19A 4k7gB-1z8wA:
0.0		 4k7gB-1z8wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 115
PRO A  61
VAL A  36
MET A   1
 None
 1.18A 4klrA-1z8wA:
4.8		 4klrA-1z8wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 LEU A  26
VAL A   5
VAL A 167
ILE A 165
 None
 0.97A 4l4cB-1z8wA:
undetectable		 4l4cB-1z8wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 SER A 162
HIS A  66
GLY A 163
LEU A  56
 None
 1.09A 6btxA-1z8wA:
undetectable		 6btxA-1z8wA:
20.54